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Glycoside Hydrolase Family 27

Activities in FamilyGalactan:galactan α-galactosyltransferase (EC 2.4.1.-);
Galactomannan exo-α-1,6-galactosidase (EC 3.2.1.-);
α-galactosidase (EC 3.2.1.22);
α-N-acetylgalactosaminidase (EC 3.2.1.49);
[retaining] β-L-arabinopyranosidase / β-L-arabinosidase (EC 3.2.1.88);
[retaining] isomalto-dextranase (EC 3.2.1.94);
Mechanism Retaining a
ClanGH-D
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (5220); Uniprot accession (92); PDB accession (61); 3D entries (14); cryst (0)
Summary
Download GH27 (7773) Taxonomic display Structure (14) Characterized (70)
| 1 | ... | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | ... | 40 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 873312   Gloeopeniophorella convolvens OM19405 v1.0 (Glocon1)      
 82647   Gloeopeniophorella convolvens OM19405 v1.0 (Glocon1)      
 127284   Gloeophyllum trabeum ATCC 11539 (Glotr1_1)      
 117566   Gloeophyllum trabeum ATCC 11539 (Glotr1_1)      
 81761   Gloeophyllum trabeum ATCC 11539 (Glotr1_1)      
 271592   Glonium stellatum (Glost2)      
 294097   Glonium stellatum (Glost2)      
 303981   Glonium stellatum (Glost2)      
 306618   Glonium stellatum (Glost2)      
 425731   Glonium stellatum (Glost2)      
 385187   Glonium stellatum (Glost2)      
 433090   Glonium stellatum (Glost2)      
 unknown   Glycine max ACU23118.1    
 unknown (fragment)   Glycine max ACU20569.1    
 unknown   Glycine max ACU20662.1    
 α-galactosidase   Glycine max AAA73963.1
AAR65332.1
ACU23822.1		    
 246896   Gongronella butleri v1.0 (Gonbut1)      
 236095   Gongronella butleri v1.0 (Gonbut1)      
 297201   Gongronella butleri v1.0 (Gonbut1)      
 GMON_LOCUS4749   Gordionus sp. m RMFG-2023 CAK9297103.1    
 GMON_LOCUS681   Gordionus sp. m RMFG-2023 CAK9290885.1    
 GMON_LOCUS6807   Gordionus sp. m RMFG-2023 CAK9300236.1    
 189280   Gorgonomyces haynaldii MP57 v1.0 (Gorhay1)      
 187073   Gorgonomyces haynaldii MP57 v1.0 (Gorhay1)      
 70739   Guillardia theta CCMP2712 (Guith1)      
 164562   Guillardia theta CCMP2712 (Guith1)      
 986879   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 774457   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 1006768   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 970688   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 929525   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 1076784   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 280975   Guyanagaster necrorhiza MCA 3950 v1 (Guyne1)      
 1817244   Gymnopilus junonius AH 44721 v1.0 (Gymjun1)      
 1773655   Gymnopilus junonius AH 44721 v1.0 (Gymjun1)      
 1712581   Gymnopilus junonius AH 44721 v1.0 (Gymjun1)      
 1678285   Gymnopilus junonius AH 44721 v1.0 (Gymjun1)      
 840181   Gymnopus androsaceus JB14 v1 (Gyman1)      
 968713   Gymnopus androsaceus JB14 v1 (Gyman1)      
 819934   Gymnopus androsaceus JB14 v1 (Gyman1)      
 869808   Gymnopus androsaceus JB14 v1 (Gyman1)      
 1008675   Gymnopus androsaceus JB14 v1 (Gyman1)      
 917637   Gymnopus androsaceus JB14 v1 (Gyman1)      
 964545   Gymnopus androsaceus JB14 v1 (Gyman1)      
 990443   Gymnopus androsaceus JB14 v1 (Gyman1)      
 525292   Gymnopus luxurians FD-317 M1 (Gymlu1)      
 37151   Gymnopus luxurians FD-317 M1 (Gymlu1)      
 92989   Gymnopus luxurians FD-317 M1 (Gymlu1)      
 43732   Gymnopus luxurians FD-317 M1 (Gymlu1)      
 43804   Gymnopus luxurians FD-317 M1 (Gymlu1)      
 49020   Gymnopus luxurians FD-317 M1 (Gymlu1)      
 777648   Gyrodon lividus BX v1 (Gyrli1)      
 777646   Gyrodon lividus BX v1 (Gyrli1)      
 793839   Gyrodon lividus BX v1 (Gyrli1)      
 334130   Halteromyces radiatus CBS 162.75 v1.0 (Halrad1)      
 125079   Halteromyces radiatus CBS 162.75 v1.0 (Halrad1)      
 274447   Halteromyces radiatus CBS 162.75 v1.0 (Halrad1)      
 α-galactosidase (Gla) 3.2.1.22 Helianthus annuus BAC66445.1 Q84VQ7  
 298930   Helicostylum pulchrum RSA 2064 v1.0 (Helpul1)      
 182706   Helobdella robusta (Helro1)      
 74316   Helobdella robusta (Helro1)      
 111560   Helobdella robusta (Helro1)      
 155996   Helobdella robusta (Helro1)      
 98483   Helobdella robusta (Helro1)      
 182708   Helobdella robusta (Helro1)      
 HERILL_LOCUS14340   Hermetia illucens CAD7091944.1    
 HERILL_LOCUS2361   Hermetia illucens CAD7079128.1    
 126780   Heterobasidion annosum v2.0 (Hetan2)      
 441362   Heterobasidion annosum v2.0 (Hetan2)      
 39280   Heterobasidion annosum v2.0 (Hetan2)      
 101995   Heterobasidion annosum v2.0 (Hetan2)      
 HAMR1_LOCUS7873   Heterobilharzia americana CAH8581825.1    
 HAMR2_LOCUS7155 (fragment)   Heterobilharzia americana CAH8610660.1    
 HAMR2_LOCUS7154 (fragment)   Heterobilharzia americana CAH8610645.1    
 ORF (fragment)   Heterocapsa triquetra AAW79376.1    
 ORF   Heterodera avenae AVA09680.1    
 1204880   Hexagonia nitida CIRM-BRFM 1802 (Hexnit1)      
 1090220   Hexagonia nitida CIRM-BRFM 1802 (Hexnit1)      
 886531   Hexagonia nitida CIRM-BRFM 1802 (Hexnit1)      
 1132462   Hexagonia nitida CIRM-BRFM 1802 (Hexnit1)      
 1113237   Hexagonia nitida CIRM-BRFM 1802 (Hexnit1)      
 α-galactosidase A (Gla;α-GAL) 3.2.1.22 Homo sapiens AAH02689.1
AAA51676.1
AAA52514.1
AAA52559.1
AAB64203.1
AAE66433.1
AAE69556.1
AAN92813.1
AAP35510.1
AAQ31818.1
AAQ68716.1
AAQ81221.1
AAY03282.1
AAY71885.1
AAY71886.1
AAY71887.1
AAY71888.1
AAY71889.1
AAY71890.1
AAY71891.1
AAY71892.1
AAY71893.1
AAY71894.1
AAY72531.1
AAY72532.1
AAY72533.1
AAY72534.1
AAY72535.1
AAY72536.1
AAY72537.1
AAY72538.1
AAY72539.1
AAY72540.1
ABE23230.1
ABL16360.1
ABL21591.1
ACH14962.1
ACK10792.1
BAA34059.1
BAD96347.1
BAF83784.1
BAG59647.1
BAT62474.1
CAA29232.1
CAA32617.1
CAB55878.1
CAC09605.1
CAE85447.1
CAV33302.1
NP_000160.1		 A0A0S3Q2A7
B4DLT5
P06280
Q53HF3
Q53Y83		 1R46[A,B]
1R47[A,B]
3GXN[A,B]
3GXP[A,B]
3GXT[A,B]
3HG2[A,B]
3HG3[A,B]
3HG4[A,B]
3HG5[A,B]
3LX9[A,B]
3LXA[A,B]
3LXB[A,B]
3LXC[A,B]
3S5Y[A,B]
3S5Z[A,B]
3TV8[A,B]
4NXS[A,B]
6IBK[A,B]
6IBM[A,B]
6IBR[A,B]
6IBT[A,B]
8K7D[A,B]
8K7E[A,B]
8K7F[A,B]
8K7G[A,B]
8K7H[A,B]
8K7I[A,B]
8K7J[A,B]
8K7K[A,B]
8K7L[A,B]
9AVS[A,B]
 α-N-acetylgalactosaminidase / α-galactosidase B (bK250D10.5;NagA;α-NAGAL) 3.2.1.22
3.2.1.49		 Homo sapiens AAA36351.1
AAA51677.1
AAA59902.1
AAB06718.1
AAE69555.1
AAH00095.1
ACM80412.1
ACM85401.1
ASU96594.1
CAB41237.1
CAG30413.1
CAX14869.1
CAX14870.1
NP_000253.1		 A0A024R1Q5
A0A248RGB1
P17050		 3H53[A,B]
3H54[A,B]
3H55[A,B]
3IGU[A,B]
4DO4[A,B]
4DO5[A,B]
4DO6[A,B]
 α-galactosidase (fragment)   Hordeum vulgare CAA74161.1    
 α-galactosidase (fragment)   Hordeum vulgare CAA74160.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAK08274.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAK07302.1    
 257216   Hortaea acidophila CBS 113389 v1.0 (Horac1)      
 294738   Hortaea acidophila CBS 113389 v1.0 (Horac1)      
 249362   Hortaea acidophila CBS 113389 v1.0 (Horac1)      
 4234   Hortaea werneckii EXF-2000 M0 v1.0 (Horwer1)      
 10358   Hortaea werneckii EXF-2000 M0 v1.0 (Horwer1)      
 3286   Hortaea werneckii EXF-2000 M0 v1.0 (Horwer1)      
 2372   Hortaea werneckii EXF-2000 M0 v1.0 (Horwer1)      
 7497   Hortaea werneckii EXF-2000 M0 v1.0 (Horwer1)      
 167620   Hyaloraphidium curvatum SAG235-1 v1.0 (Hyacur1)      
 374486   Hyaloraphidium curvatum SAG235-1 v1.0 (Hyacur1)      
 76385   Hyaloraphidium curvatum SAG235-1 v1.0 (Hyacur1)      
 24370   Hyaloraphidium curvatum SAG235-1 v1.0 (Hyacur1)      
 672907   Hyaloraphidium curvatum SAG235-1 v1.0 (Hyacur1)      
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