| Activities in Family | Lytic polygalacturonic acid monooxygenase / polygalacturonic acid oxidase (C4-dehydrogenating) (EC 1.14.99.-); |
|---|---|
| Mechanism | monooxygenase |
| Note | Family created after the characterization of Phytophthora infestans enzymes by Sabbadin et. al., (PMID:34385392). AA17 are copper-dependent lytic polysaccharide monooxygenases (LPMOs) found in oomycetes; binding and cleavage of homogalacturonan with oxidation of C-4 has been demonstrated for three AA17 LPMOs from Phytophtora infestans; oxidative polygalacturonase; C4-oxidative cleavage of polygalacturonic acid, generating a C4-ketone in a b-position relative to one carboxylic group, resulting in an unstable b-keto acid that undergoes spontaneous decarboxylation and tautomerization |
| Statistics | GenBank accession (88); Uniprot accession (4); PDB accession (1); 3D entries (1); cryst (0) |
| Eukaryota | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| lytic polygalacturonic acid monooxygenase (PiAA17C; PITG_04949) | 1.14.99.- | pubmed |
Phytophthora infestans T30-4 | EEY68486.1 | D0N2F7 | 6Z5Y[A,B] | |
| lytic polygalacturonic acid monooxygenase (PiAA17A; PITG_04947) | 1.14.99.- | pubmed |
Phytophthora infestans T30-4 | KAF4046070.1 EEY68484.1 |
A0A833WPX8 D0N2F5 |
||
| lytic polygalacturonic acid monooxygenase (PiAA17B; PITG_04948) | 1.14.99.- | pubmed |
Phytophthora infestans T30-4 | EEY68485.1 | D0N2F6 | ||
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