Auxiliary Activity Family 17

Activities in FamilyLytic polygalacturonic acid monooxygenase (C4-hydroxylating) (EC 1.14.99.-)
Mechanism monooxygenase
NoteFamily created after the characterization of Phytophthora infestans enzymes by Sabbadin et. al., (PMID:34385392). AA17 are copper-dependent lytic polysaccharide monooxygenases (LPMOs) found in oomycetes; binding and cleavage of homogalacturonan with oxidation of C-4 has been demonstrated for three AA17 LPMOs from Phytophtora infestans; oxidative polygalacturonase; C4-oxidative cleavage of polygalacturonic acid, generating a C4-ketone in a b-position relative to one carboxylic group, resulting in an unstable b-keto acid that undergoes spontaneous decarboxylation and tautomerization
Statistics GenBank accession (418); Uniprot accession (3); PDB accession (1); 3D entries (1); cryst (0)

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