Auxiliary Activity Family 17

Activities in FamilyLytic polygalacturonic acid monooxygenase (C4-hydroxylating) (EC 1.14.99.-)
Mechanism monooxygenase
NoteFamily created after the characterization of Phytophthora infestans enzymes by Sabbadin et. al., (PMID:34385392). AA17 are copper-dependent lytic polysaccharide monooxygenases (LPMOs) found in oomycetes; binding and cleavage of homogalacturonan with oxidation of C-4 has been demonstrated for three AA17 LPMOs from Phytophtora infestans; oxidative polygalacturonase; C4-oxidative cleavage of polygalacturonic acid, generating a C4-ketone in a b-position relative to one carboxylic group, resulting in an unstable b-keto acid that undergoes spontaneous decarboxylation and tautomerization
Statistics GenBank accession (404); Uniprot accession (3); PDB accession (1); 3D entries (1); cryst (0)
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lytic polygalacturonic acid monooxygenase (PITG_04949) 1.14.99.- Phytophthora infestans T30-4 EEY68486.1 D0N2F7
6Z5Y[A] 1.01

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