Polysaccharide Lyase Family 8

Mechanism	b-elimination
3D Structure Status	( α / α ) ₆ toroid + anti-parallel β-sheet
External resources	CAZypedia;
Statistics	GenBank accession (6006); Uniprot accession (35); PDB accession (54); 3D entries (13); cryst (1)

Summary

Download PL8 (6547) Taxonomic display Structure (13 - 1 cryst) Characterized (42) Activities in Family (8)

Bacteria

Protein Name

EC#

Organism

GenBank

Uniprot

PDB/3D

Carbohydrate Ligands

Resolution (Å)

Subf

xanthan lyase (BXL; Xly)

4.2.2.12

Bacillus sp. GL1

BAB21059.1

Q9AQS0

1J0M[A]		2.30
1J0N[A]		2.40
1X1H[A]		2.30
1X1I[A]		1.80
1X1J[A]	unknown-(1-4)-D-1-deoxy-GlcpA	2.10
2E22[A]	β-D-Manp	2.40
2E24[A]		2.15

chondroitin sulfate ABC lyase

4.2.2.5
4.2.2.19

Bacteroides thetaiotaomicron WAL2926

ABV21364.1

C5G6D7

2Q1F[A,B]

2.85

exo-hyaluronate lyase (HylB; HYL-IB/II; PPA0380)

4.2.2.-

Cutibacterium acnes KPA171202

AAT82132.1

P0CZ00
P0CZ01

8FNX[A]		2.10
8G0O[A,B]		2.10

hyaluronate lyase (HylA;HMPREF0675_3415)

4.2.2.1

Cutibacterium acnes SK137

ADD99051.1

A0A2B7ICX0

8FYG[A,B]

2.05

hyaluronate lyase / chondroitin AC lyase (ArthroAC) (partial)

4.2.2.1
4.2.2.5

Paenarthrobacter aurescens

P84141

1RW9[A]		1.35
1RWA[A]		1.30
1RWC[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc	1.90
1RWF[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3	1.45
1RWG[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3	1.50
1RWH[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3	1.25

xanthan lyase (PXL)

4.2.2.12

Paenibacillus nanensis 62047 / Paenibacillus sp. 62047

AXR85425.1

A0A3S7RW91
A0A493R6T1

6F2P[A]

2.60

chondroitin AC lyase (CslA;ChnAC;Phep_0786)

4.2.2.5

Pedobacter heparinus DSM 2366

ACU03008.1
AAC83383.1

Q59288

1CB8[A]		1.90
1HM2[A]	α-L-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-α-L-IdopA-(1-3)-β-D-GalpNAc4SO3	2.00
1HM3[A]	β-D-GlcpA-(1-3)-β-D-GlcpNAc	2.10
1HMU[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3	2.00
1HMW[A]	β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-GalpNAc6SO3	2.30

chondroitin sulfate ABC lyase I / chondroitinase ABC (ChABC; csABC I)

4.2.2.5
4.2.2.19

Proteus vulgaris

2109195A
ABE23097.1
ACN04689.1
ACQ12496.1
ACQ12497.1
ACW17440.1
ACW17441.1
ACY01450.1

P59807

1HN0[A]		1.90
7EIP[A]		1.88
7EIQ[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3 β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO3	1.80
7EIR[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc6SO3 β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc6SO3	1.92
7EIS[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc	2.50
7YKE[A]	β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO36SO3	1.88

chondroitin AC lyase II (ChACII)

4.2.2.5

Proteus vulgaris ATCC 6896

AAB43333.1
ABU46331.1

C7S340

cryst

hyaluronate lyase (HylB; SaHyl; SagHL; Gbs1270)

4.2.2.1

Streptococcus agalactiae NEM316

CAD46929.1
AAA56749.1
NP_735714.1

Q53591

1F1S[A]		2.10
1I8Q[A]	β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc	2.20
1LXM[A]	β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc	2.20

hyaluronate lyase (HysA)

4.2.2.1

Streptococcus pneumoniae R6

AAK99090.1
AAA53685.1
AAA53686.1
AAT16666.1
ACK14456.1
ACW45175.1
NP_357880.1

Q54873
Q8CWU3

1C82[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc	1.70
1EGU[A]		1.56
1F9G[A]		2.00
1LOH[A]	β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc	2.00
1LXK[A]	β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc	1.53
1N7N[A]		1.55
1N7O[A]		1.50
1N7P[A]		1.55
1N7Q[A]	β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc	2.30
1N7R[A]	β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc	2.20
1OJM[A]	α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc	1.78
1OJN[A]		1.60
1OJO[A]		1.75
1OJP[A]		1.90
1W3Y[A]		1.65
2BRP[A]		2.0
2BRV[X]		3.3
2BRW[A,B]		2.8