| Mechanism | b-elimination |
|---|---|
| 3D Structure Status | 7-fold β-propeller |
| Note | Formerly known as glycoside hydrolase family GH145 (Munoz-Munoz et al., PMID=28396425); subsequently reclassified as PL42 based on the publications of Kondo T et al. JBC 2021 (PMID=34303708) and Munoz-Munoz et al., mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25. |
| External resources | CAZypedia; |
| Statistics | GenBank accession (1054); Uniprot accession (5); PDB accession (11); 3D entries (5); cryst (0) |
| Bacteria | ||||||||||||||||||||||||
| Protein Name | EC# | Organism | GenBank | Uniprot |
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| α-L-Rhα-1,4-GlcA glucuronate lyase (BACCELL_00856) (formerly BcGH145) | 4.2.2.28 | Bacteroides cellulosilyticus DSM 14838 | EEF91490.1 | E2N9B1 |
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| BACINT_00347 | Bacteroides intestinalis DSM 17393 |
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| Bovatus_03783 / BACOVA_03493 | Bacteroides ovatus ATCC 8483 | ALJ48388.1 | A7M066 |
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| L-Rhα-a-1,4-GlcA glucuronate lyase / exo-acting α-L-rhamnosidase (BT3686; BT_3686) (formerly BtGH145) | 4.2.2.28 | Bacteroides thetaiotaomicron VPI-5482 | AAO78791.1 | Q8A1H5 |
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| Eukaryota | ||||||||||||||||||||||||
| Protein Name | EC# | Organism | GenBank | Uniprot |
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| α-L-rhamnose-1,4-D-glucuronate lyase (Forham1) | 4.2.2.28 | Fusarium oxysporum 12S | BCT36655.1 | A0A8D5PZ14 |
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