| Mechanism | b-elimination |
|---|---|
| 3D Structure Status | 7-fold β-propeller |
| Note | Formerly known as glycoside hydrolase family GH145 (Munoz-Munoz et al., PMID=28396425); subsequently reclassified as PL42 based on the publications of Kondo T et al. JBC 2021 (PMID=34303708) and Munoz-Munoz et al., mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25. |
| External resources | CAZypedia; |
| Statistics | GenBank accession (1054); Uniprot accession (5); PDB accession (11); 3D entries (5); cryst (0) |
| Activity Id | EC# | Activity Name | Residue -2 | Bond -1 | Residue -1 | Reacting Bond | Residue +1 | Bond +1 | Residue +2 | Reactant |
| L372 | 4.2.2.28 | L-rhamnose-a-1,4-D-glucuronate lyase | [aLRhap | 1,4 | bDGlcpA | 1,6 | bDGalp | |||
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