Activities in Family	[retaining] GDP-valeniol: validamine 7-phosphate valeniolyltransferase (EC 2.-.-.-); α,α-trehalose-6-phosphate synthase (UDP-forming) (EC 2.4.1.15); Glucosylglycerol-phosphate synthase (EC 2.4.1.213); α,α-trehalose-6-phosphate synthase (GDP-forming) (EC 2.4.1.36); Trehalose-6-P phosphatase (EC 3.1.3.12);
Mechanism	Retaining
3D Structure Status	GT-B
Statistics	GenBank accession (20137); Uniprot accession (85); PDB accession (41); 3D entries (15); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Bmul_0897 (OtsA)		Burkholderia multivorans ATCC 17616	ABX14591.1 BAG44255.1		5UOF[A,B] 1.70
Bcep1808_2483		Burkholderia vietnamiensis G4	ABO55481.1		5TVG[A,B,C,D,E,F,G,H] 2.30
Trehalose-6-phosphate synthase	2.4.1.15	Escherichia coli NCTC9077_02568		P31677	6JAK[A,B,C,D] 2.41 6JAK[nd] 2.41
α,α-trehalose-phosphate synthase (OtsA;Tps;b1896)	2.4.1.15	Escherichia coli str. K-12 substr. MG1655	AIZ91009.1 AAA68604.1 AAC74966.1 AAE52301.1 AAN95312.1 AAW99267.1 ACI81904.1 ACO57635.1 ALI40335.1 AMC94875.1 AUG16661.1 AVI56412.1 AYG19054.1 CAA48913.1 CAB42256.1 CAB58460.1 CAB58465.1 CBF70287.1 CBG04443.1 NP_416410.1	P31677 Q6PQ82	1GZ5[A] P-(0-6)-α-D-Glcp 2.43 1UQT[A] 2.0 1UQU[A] 2.0 2WTX[A,B,C,D] <carb_like_VDO> 2.20
α,α-trehalose-6-phosphate synthase (RMCT_1906)	2.4.1.15	Mycolicibacterium thermoresistibile	WP_003926306.1	A0A117IMA6 G7CGT2	5JIJ[A] 1.82 5JIO[A] P-(0-6)-α-D-Glcp 1.71 5K41[A] 1.97 5K42[A] 1.92 5K44[A] 1.93 5K5C[A] α-D-Glcp-(1-1)-α-D-Glcp 1.85 5L3K[A,B,C,D,E,F,G,H] P-(0-6)-β-D-Fruf 2.31
α,α-trehalose-phosphate synthase (Bxe_A3374)		Paraburkholderia xenovorans LB400	ABE29611.1		5HXA[A] 2.00
α,α-trehalose-phosphate synthase (Bxe_A1242)		Paraburkholderia xenovorans LB400	ABE31711.1		5V0T[A,B,C,D,E,F,G,H] P-(0-6)-α-D-Glcp 1.95
GDP-valeniol: validamine 7-phosphate valeniolyltransferase (ValL;VldE)	2.-.-.-	Streptomyces hygroscopicus subsp. limoneus KCCM 11405	ABC67269.1	H2K885 Q15JG1	3T5T[A,B] 1.70 3T7D[A,B] α-D-Glcp-(1-1)-α-D-Glcp 1.70 3VDM[A,B] 1.98 3VDN[B] 2.55 4F96[A,B] 2.15 4F97[A,B] <carb_like_VDO> 2.11 4F9F[A,B,C,D,E,F] α-D-Glcp-(1-1)-α-D-Glcp 2.81 8IYE[A,B] 1.90 8IYF[A,B] 1.90
trehalose-6-phosphate synthase (OtsA;SVEN_4043)	2.4.1.36	Streptomyces venezuelae ATCC 10712	CCA57329.1 QES00438.1	F2RH01	5LQD[A,B,C,D] 1.95
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
trehalose-6-phosphate synthase A (AFUA_6G12950)		Aspergillus fumigatus Af293	EAL89135.1		5HVM[A,B] <carb_like_VDM> 2.82
trehalose-6-phosphate synthase B (AFUA_2G04010)		Aspergillus fumigatus Af293	EAL87495.1		5HVO[A,B,C,D] <carb_like_VDM> 2.47
trehalose-6-phosphate phosphatase (Tps2)	3.1.3.12	Candida albicans	CAC17748.1	G1UAE0 Q5AI14	5DXF[A,B] 2.56
α,α-trehalose-phosphate synthase (Tps1; CAALFM_CR05720WA)	2.4.1.15	Candida albicans SC5314	AOW31288.1 AAV05161.1 CAA69223.1 CBF70450.1 CBF98938.1	C4YM18 Q92410	5HUT[A,B] 1.90 5HUU[A,B] P-(0-6)-α-D-Glcp 2.37 5HUV[A,B] 2.00 5HVL[A,B] <carb_like_VDM> 1.80 9NIQ[A] 9NKB[A,B]
a,α-trehalose-6-phosphate synthase (CNAG_05292)	2.4.1.15	Cryptococcus neoformans H99	AFR94553.2	J9VJZ1	8FHW[A,B,C,D] P-(0-6)-α-D-Glcp 3.20 8FO1[A,B,C,D] 3.30
trehalose-6-phosphate synthase (Tps1; MoTps1; MG03860.4)	2.4.1.15	Pyricularia oryzae 70-15	XP_361386.1	G4NHF4	6JBI[A,B] 2.50 6JBR[A,B,D,F,H,K,M,O] 2.03 6JBW[A,B] 2.65
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