Activities in Family	GDP-α-D-Manp: β-1,2-D-mannosyltransferase (EC 2.4.1.374);
Mechanism	inverting
Note	Created after (Sernee et al., Cell Host & Microbe, 2019), in press [PMID=31513773]. The dual activity mannosyltransferases/phosphorylases of six Leishmania proteins allows the management of mannogen (storage polysacharride). Family evolutionary related the bacterial GH130 phosphorylases.
Statistics	GenBank accession (729); Uniprot accession (6); PDB accession (6); 3D entries (4); cryst (0)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
LMJF_10_1260		Leishmania major strain Friedlin	CAJ03084.1 CAG9570116.1		2B4W[A] 1.98
MTP1 (LMXM_10_1230)	2.4.1.374	Leishmania mexicana MHOM/GT/2001/U1103	CBZ24446.1 XP_003872964.1	E9AND7	6Q4W[A,B] 1.55
MTP2 (LMXM_10_1240)	2.4.1.374	Leishmania mexicana MHOM/GT/2001/U1103	XP_003872965.1 CBZ24447.1	E9AND8	6Q4X[A,B] 1.55 6Q4Y[A,B] α-D-Manp β-D-Manp 1.70 6Q4Z[A,B] β-D-Manp-(1-2)-α-D-Manp 1.55
MTP4 (LMXM_10_1260)	2.4.1.374	Leishmania mexicana MHOM/GT/2001/U1103	CBZ24449.1 XP_003872967.1	E9ANE0	6Q50[A] 1.60
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