Mechanism	Inverting and retaining a
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu for inverting members; Asp for retaining members
Catalytic Proton Donor	Glu
Note	Created based on a paper by Hughes et al. (2003) Oral Microbiol Immunol. 18:309-312 (PMID: 12930523); *Mechanistic and structural elucidation by Gloster et al. (2008) Chem. Biol., Oct 8 (PMID:18848471); the inverting a-glucosidases (EC 3.2.1.20) could be renamed glucoamylases (EC 3.2.1.3 according to Kitamura et al. (2008) J. Biol. Chem., Nov 3 (PMID:18981178)
External resources	CAZypedia;
Statistics	GenBank accession (6850); Uniprot accession (13); PDB accession (17); 3D entries (6); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-glucosidase / glucoamylase (BoSusB; BoGH97CSus; Bovatus_03808)	3.2.1.3	pubmed	Bacteroides ovatus ATCC 8483	ALJ48413.1		9BS5[A,B]
α-glucosidase (BT0683)	3.2.1.20	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO75790.1 NP_809596.1	Q8A9Y2
α-galactosidase (BtGH97b; BT1871; BT_1871)	3.2.1.22	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76978.1 NP_810784.1	Q8A6L0	3A24[A,B] 5E1Q[A,B]
α-galactosidase (BT3294; BT_3294)	3.2.1.22	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78400.1 NP_812206.1	Q8A2L1
α-mannan α-galactosidase (BT2620)	3.2.1.22	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO77727.1 NP_811533.1	Q8A4H9
α-galactosidase (BT3664; BT_3664)	3.2.1.22	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78769.1 NP_812575.1	Q8A1J7
bifunctional β-L-arabinopyranosidase/α-D-galactosidase (BT3661; BT_3661)	3.2.1.22 3.2.1.88	pubmed pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78766.1 NP_812572.1	Q8A1K0	5XFM[A,B,C,D]
α-glucosidase / glucoamylase (SusB; BtGH97a; BT3703; BT_3703)	3.2.1.3	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78808.1 AAC44671.1 NP_812614.1	G8JZS4 P71094	2D73[A,B] 2JKA[A,B] 2JKE[A,B] 2JKP[A,B] 2ZQ0[A,B] 3WFA[A,B]
α-galactosidase (FII2_GH97)	3.2.1.22	pubmed	Flavimarina sp. Hel_I_48	WP_031425947.1
dextran exo-α-1,6-glucosidase (FjGH97A; Fjoh_4429)	3.2.1.70	pubmed	Flavobacterium johnsoniae UW101	ABQ07433.1	A5FBI0	8WG0[A,B,C,D] 8WG1[A,B,C,D] 8WG2[A,B,C,D]
dextran exo-α-1,6-glucosidase (PspAG97A) (Ag97A)	3.2.1.70	pubmed	Pseudoalteromonas sp. K8	AMB20699.1	A0A0Y0DFX2	5HQ4[A] 5HQA[A] 5HQB[A] 5HQC[A]
α-glucosidase (SusB;Aglu;BFO_2272)	3.2.1.20	pubmed	Tannerella forsythia 92A2	AEW20125.1 AAO33827.1	G8UJE0 Q84FT4
retaining α-galactosidase (CapGH97)	3.2.1.22	pubmed	uncultured Bacteroidaceae bacterium	UMW87591.1
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-galactosidase (Agas2)	3.2.1.22	pubmed	insect gut metagenome	ARK08558.1	A0A1W6DZM5
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