Glycoside Hydrolase Family 43 / Subf 4

Mechanism	Inverting e
Clan	GH-F
3D Structure Status	5-fold β-propeller
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Glu
Note	Many members have been assigned to subfamilies as described by Mewis et al. (2016) Appl. Environm. Microbiol. 82:1686-1692 (PMID: 26729713).
External resources	CAZypedia;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (28); Uniprot accession (18); PDB accession (14); 3D entries (5); cryst (0)

Summary

Download GH43_4 (1842) Taxonomic display Structure (5) Characterized (21) Activities in Sub Family (2)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
endo-α-1,5-L-arabinanase (Abn2; YxiA; J3A; BsArb43B; BSU39330) (Arb43B)	3.2.1.99	pubmed	Bacillus subtilis subsp. subtilis str. 168	CAB15969.2 ACB06752.1 AIY95249.1 AQR83975.1 AQR88190.1 CAB15969.1 NP_391812.1	A0A6M4JQW9 B3FRL6 P42293	2X8F[A,B] 2X8S[A,B] 2X8T[A,B] 4COT[A]	4
endo-α-1,5-L-arabinanase (BT0360;BT_0360) (branched arabinan specific)	3.2.1.99	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO75467.1 NP_809273.1	Q8AAV4		4
endo-α-1,5-L-arabinanase (BT0367;BT_0367) (linear arabinan-specific)	3.2.1.99	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO75474.1 NP_809280.1	Q8AAU7		4
arabinan endo-α-1,5-L-arabinofuranosidase 43A (Abn1; BflsABN43A)	3.2.1.99	pubmed	Bifidobacterium longum subsp. suis DSM 20211	WP_032684165.1	A0A087B7X1		4
arabinan endo-α-1,5-L-arabinofuranosidase 43B (Abn2; BflsABN43B)	3.2.1.99	pubmed	Bifidobacterium longum subsp. suis DSM 20211	WP_032684164.1	A0A087B7X0		4
arabinan endo-α-1,5-L-arabinosidase (CpAbn43A) (Abn43A)	3.2.1.99	pubmed	Caldanaerobius polysaccharolyticus ATCC BAA-17	WP_026486268.1			4
endo-α-1,5-L-arabinanase (Calhy_1629)	3.2.1.99	pubmed	Caldicellulosiruptor hydrothermalis 108	ADQ07344.1	E4QC52		4
endo-α-1,5-L-arabinanase (Csac_1560)	3.2.1.99	pubmed	Caldicellulosiruptor saccharolyticus DSM 8903	ABP67152.1	A4XJR7		4
α-L-arabinase (Dtur_1729)	3.2.1.99	pubmed	Dictyoglomus turgidum DSM 6724	ACK43001.1			4
endo-α-1,5-L-arabinanase (AbnA) (extracellular)	3.2.1.99	pubmed	Geobacillus stearothermophilus T-6 NCIMB 40222	ACE73680.1	B3EYN2	5HO0[A] 5HO2[A] 5HO9[A,B] 5HOF[A] 5HP6[A]	4
endo-α-1,5-L-arabinanase (AbnZ3;YxiA3)	3.2.1.99	doi	Paenibacillus polymyxa Z6	AHA50064.1	V5LEX8		4
endo-α-1,5-L-arabinanase (AbnZ2;Yxia1)	3.2.1.99	doi	Paenibacillus polymyxa Z6	AHA50063.1	V5LFQ5		4
endo-arabinanase (Abn;Tth Abn;Theth_1128)	3.2.1.99	pubmed	Pseudothermotoga thermarum DSM 5069	AEH51204.1	F7YX80		4
arabinanase (GH43D;RUM_09280) (Ara43D)	3.2.1.99	pubmed	Ruminococcus champanellensis 18P13 = JCM 17042	CBL17100.1	D4LBV5		4
endo-α-1,5-L-arabinanase (AbnA;TpABN;Tpet_0637)	3.2.1.99	pubmed	Thermotoga petrophila RKU-1	ABQ46657.1	A5IKD4	4KC7[A,B,C] 4KC8[A,B,C]	4
endo-α-1,5-L-arabinanase (Arn2)	3.2.1.99	pubmed	uncultured bacterium	ADB43998.1	D2XML7		4
endo-α-1,5-L-arabinanase (Arn2;ARN2) (partial)	3.2.1.99	pubmed	uncultured rumen bacterium			4KCA[A] 4KCA[B]	4
endo-arabinanase (MC68GH43-1)	3.2.1.99	pubmed	Xylanivirga thermophila	UKG18727.1			4
endo-arabinanase (C72GH43-2)	3.2.1.99	pubmed	Xylanivirga thermophila	UKG18730.1			4
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
arabinanase 43A (G12-10;GH43b(G12);BN138_172) (Abn43A)	3.2.1.99	pubmed	termite gut metagenome	CCO20984.1	S0DDY0		4
exo-α-L-1,5-arabinanase 43B (G12-19;GH43a(G12);BN138_181) (Abn43B)	3.2.1.-	pubmed	termite gut metagenome	CCO20993.1	S0DDV5		4
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