Mechanism	Retaining a
3D Structure Status	mannosidase fold
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Not known
External resources	CAZypedia;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (13748); Uniprot accession (92); PDB accession (84); 3D entries (13); cryst (2)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
mannosyl-oligosaccharide α-1,6-mannosidase (Bl_Man38A; BL1327)	3.2.1.114 3.2.1.114	Bifidobacterium longum NCC2705	AAN25127.1 NP_696491.1	Q8G4Q1	7UFR[A,B,C,D] 2.70 7UFU[A,B,C,D] α-D-Manp 2.70
mannosyl-oligosaccharide α-1,2-mannosidase (Bl_Man38B; BL1328)	3.2.1.113	Bifidobacterium longum NCC2705	AAN25128.1 NP_696492.1	Q8G4Q0	7UFS[A,B,C,D] 3.40
mannosyl-oligosaccharide exo-α-1,2-mannosidase (Bl_Man38C; BL1329)	3.2.1.113	Bifidobacterium longum NCC2705	AAN25129.1 NP_696493.1	Q8G4P9	7UFT[A,B,C,D] 2.90
α-mannosidase (EF1707;EF_1707)		Enterococcus faecalis V583	AAO81483.1 AAR57537.1 NP_815413.1		3LVT[A] 2.55 5KBP[A,B] 2.40
mannosyl-oligosaccharide α-1,3-mannosidase (SPy1604)	3.2.1.-	Streptococcus pyogenes M1 GAS SF370	AAK34381.1 NP_269660.1	Q99YP5	2WYH[A,B] 1.90 2WYI[A,B] <carb_like_SWA> 2.60
α-mannosidase (cytosolic) (TM1851;Tmari_1866)	3.2.1.24	Thermotoga maritima MSB8	AAD36913.1 AGL50790.1 AHD18252.1 AKE29607.1 NP_229647.1	Q9X2G6 R4NSK1	cryst
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-mannosidase (Man2B1;ManB) (lysosomal)	3.2.1.24	Bos taurus	AAC48763.1 AAB67726.2 NP_776986.2	Q29451	1O7D[A,B,C,D,E] 2.70
α-1,2/3/6-mannosidase (JBM; JBAM; Jbα-man) (peptide sequencing) (partial)	3.2.1.24 3.2.1.113 3.2.1.114 3.2.1.114	Canavalia ensiformis		C0HJB3	6B9P[A,B] β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc 2.00 6B9O[A,B] 1.84
GlcNAcMan5GlcNAc2 α-1,6-mannosidase / GlcNAcMan4GlcNAc2 α-1,3-mannosidase / α-mannosidase II (GMII; dGMII; α-Man-II; CG18474)	3.2.1.114 3.2.1.114	Drosophila melanogaster	CAA54732.1 AAF54375.1 AAF54376.1 AAM50118.1 AGB95795.1 CAA10755.1 CAH33908.1 CBA12847.1 CBA34887.1 NP_524291.2	A0A0B4KFG0 Q24451	1HTY[A] 1.40 1HWW[A] <carb_like_SWA> 1.87 1HXK[A] <carb_like_DMJ> 1.50 1PS3[A] β-D-GlcpNAc <carb_like_KIF> 1.80 1QWN[A] α-L-Gulp5F-(1-4)-ASP 1.20 1QWU[A] α-L-Gulp5F-(1-4)-ASP 2.03 1QX1[A] β-D-Manp2F-(1-4)-ASP 1.30 1R33[A] <carb_like_LKA> 1.80 1R34[A] <carb_like_LKS> 1.95 1TQS[A] <carb_like_SSO> 1.30 1TQT[A] <carb_like_SSD> 1.90 1TQU[A] <carb_like_GHA> 2.03 1TQV[A] <carb_like_SSE> 2.03 1TQW[A] 1.20 2ALW[A] <carb_like_MNM> 1.86 2F18[A] <carb_like_GB1> 1.30 2F1A[A] 1.45 2F1B[A] <carb_like_GB3> 1.45 2F7O[A] <carb_like_MSN> 1.43 2F7P[A] <carb_like_2SK> 1.28 2F7Q[A] <carb_like_AOL> 1.85 2F7R[A] <carb_like_SK3> 1.35 2FYV[A] <carb_like_W72> 1.90 2OW6[A] <carb_like_NK1> 1.19 2OW7[A] <carb_like_NK2> 1.77 3BLB[A] <carb_like_SWA> 1.30 3BUB[A] 1.38 3BUD[A] 1.85 3BUI[A] 1.25 3BUP[A] α-D-Manp 2.03 3BUQ[A] α-D-Manp 2.01 3BVT[A] α-D-Manp-(1-3)-α-D-Manp3S-(1-1)-methyl 1.30 3BVU[A] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp3S-(1-1)-methyl 1.12 3BVV[A] α-D-Manp6SH-(1-6)[α-D-Manp-(1-3)]-β-D-Manp-(1-1)-methyl 1.30 3BVW[A] α-D-Manp-(1-6)-α-D-Manp6SH-(1-6)[β-D-GlcpNAc-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-1)-methyl 1.20 3BVX[A] α-D-Manp-(1-6)-α-D-Manp-(1-6)[β-D-GlcpNAc-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-1)-methyl 1.10 3CV5[A] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-3)]-β-D-Manp 1.60 3CZN[A] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[β-D-GlcpNAc-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-α-D-GlcpNAc 1.40 3CZS[A] α-D-Manp 1.30 3D4Y[A] <carb_like_MVL> 1.52 3D4Z[A] <carb_like_GIM> 1.39 3D50[A] <carb_like_OEV> 1.79 3D51[A] <carb_like_GOX> 1.43 3D52[A] 1.60 3DDF[A] <carb_like_GB6> 1.20 3DDG[A] 1.74 3DX0[A] <carb_like_MSN> 1.70 3DX1[A] <carb_like_YHO> 1.21 3DX2[A] <carb_like_MZB> 1.40 3DX3[A] <carb_like_YTB> 1.42 3DX4[A] <carb_like_GOO> 1.38 3EJP[A] <carb_like_HN2> 1.32 3EJQ[A] <carb_like_HN3> 1.45 3EJR[A] <carb_like_HN4> 1.27 3EJS[A] <carb_like_HN5> 1.35 3EJT[A] <carb_like_HN6> 1.35 3EJU[A] <carb_like_HN7> 1.32 6RPC[A] 1.69 6RQZ[A] 1.53 6RRH[A] 2.07 6RRJ[A] 1.95 6RRN[A] 1.59 6RRU[A] 1.90 6RRW[A] 2.15 6RRX[A] 1.84 6RRY[A] 1.86 6RS0[A] 1.80 9FTQ[A] 9FTR[A]
lysosomal α-mannosidase (LManII;dLM408;CG6206;Dmel_CG6206)	3.2.1.24	Drosophila melanogaster	AAD38576.1 AAF52958.1 AAF52958.2 AAN10754.1 NP_609408.1 NP_723591.1	Q8IPB7 Q9VKV1	cryst
α-mannosidase (Ams1;YGL156W;G1861)	3.2.1.24	Saccharomyces cerevisiae S288c	CAA88536.1 AAA34422.1 AAA34423.1 CAA96868.1 NP_011359.1	P22855	5JM0[A] 6.30
α-mannosidase (weak activity) (Ams1; SpAms1; Mns2; SPAC513.05) (ER)	3.2.1.24	Schizosaccharomyces pombe 972h-	CAB58728.1 CAK8727126.1 NP_593979.1	Q9UT61	6LZ1[A,B,C,D] 3.20 7DD9[A,B] 2.40
CTHT_0067100		Thermochaetoides thermophila DSM 1495	EGS17385.1		7VQO[A,B,C,D] 2.19
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