Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (2700); Uniprot accession (41); PDB accession (21); 3D entries (6); cryst (1)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
β-mannosidase (BT0458;BT_0458) (Man2A)	3.2.1.25	Bacteroides thetaiotaomicron VPI-5482	AAO75565.1 NP_809371.1	Q8AAK6	2JE8[A,B] 1.7 2VJX[A,B] <carb_like_IFL> 1.85 2VL4[A,B] <carb_like_MNM> 1.90 2VMF[A,B] <carb_like_MVL> 2.1 2VO5[A,B] 2.3 2VOT[A,B] 1.95 2VQT[A,B] <carb_like_15A> 2.1 2VQU[A,B] <carb_like_NOY> 1.9 2VR4[A,B] <carb_like_17B> 1.8 2WBK[A,B] β-D-Manp2F-(1-1)-<non_carb> 2.10 7OP6[A,B] 2.05 7OP7[A,B] 1.85	13
β-mannosidase (DtMan;DICTH_1692)	3.2.1.25	Dictyoglomus thermophilum H-6-12	ACI19676.1	B5YAN4	5N6U[A,B,C,D] D-1-deoxy-Manp 3.08	13
exo-β-mannanase (XacMan2A; XAC3075) (XacMan2A)	3.2.1.25	Xanthomonas citri pv. citri str. 306	AAM37920.1 NP_643384.1	A0AAI8ETJ7 Q8PI23	6BYC[A] 1.90 6BYE[A,B] β-D-Manp 2.13 6BYG[A,B] β-D-Manp 2.00 6BYI[A,B] β-D-Manp 2.20	13
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
β-mannosidase (MndA;AnigerBM2;An11g06540)	3.2.1.25	Aspergillus niger CBS 513.88	CAK96951.1 XP_001394632.2	A2QWU9	cryst	13
β-mannosidase	3.2.1.25	Mus musculus	AAK18177.1 AAH31409.1 BAE24954.1 BAE38715.1 BAE41690.1 NP_081564.1	A0A0R4J092 Q8K2I4 Q99MS1	6DDT[A] 2.10 6DDU[A] β-D-Manp 2.67	13
β-mannosidase (ThMan2A) (Man2A)	3.2.1.25	Trichoderma harzianum IOC-3844	AID21733.1	A0A068CMC5 A0A075B5H6	4CVU[A] 1.90 4UOJ[A,B] 2.50	13
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