Mechanism	Retaining e
Clan	GH-K
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; Tay-Sachs Disease;
Statistics	GenBank accession (25009); Uniprot accession (191); PDB accession (122); 3D entries (38); cryst (0)

Activity Id	EC#	Activity Name	Residue -2	Bond -1	Residue -1	Reacting Bond	Residue +1	Bond +1	Residue +2	Reactant
H38	3.2.1.52	b-N-acetylhexosaminidase			[bDGlcpNAc/bDGalpNAc	1,X	alcohol			H2O
H39	3.2.1.53	b-N-acetylgalactosaminidase			[bDGalpNAc	1,X	alcohol			H2O
H73	3.2.1.96	mannosyl-oligosaccharide endo-b-1,4-N-acetylglucosaminidase	bDManp	1,4	bDGlcpNAc	1,4	bDGlcpNAc	1,X	Asn	H2O
H111	3.2.1.140	antigen b-1,3-lacto-N-biosidase	[bDGalp	1,3	bDGlcpNAc	1,3	bDGalp	1,X	alcohol	H2O
H171	3.2.1.-	poly-N-acetylglucose endo-b-1,6-N-acetylglucosaminidase	bDGlcpNAc	1,6	bDGlcpNAc	1,6	bDGlcpNAc	1,6	bDGlcpNAc	H2O
H181	3.2.1.-	chitin exo-b-1,4-N-acetylglucosaminidase			[bDGlcpNAc	1,4	bDGlcpNAc	1,4	bDGlcpNAc	H2O
H200	3.2.1.-	b-N‐acetyl-lactosaminidase	[bDGalp	1,4	bDGlcpNAc	1,X	alcohol			H2O
H219	3.2.1.-	b-N-Acetyl-(6-sulfo)-glucosaminidase			[bDGlcpNAc_6S	1,X	alcohol			H2O
H418	3.2.1.-	poly-N-acetylglucose exo-b-1,6-N-acetylglucosaminidase			[bDGlcpNAc	1,6	bDGlcpNAc	1,6	bDGlcpNAc	H2O
H432	3.2.1.-	LNT2 b-1,4-N-acetylglucosidase			[bDGlcpNAc	1,3	bDGalp	1,4	DGlcp	H2O
H433	3.2.1.-	Lacto-N-biosidase b-N-acetylglucosaminidase	[bDGalp	1,3	bDGlcpNAc	1,X	alcohol			H2O
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