Mechanism	Retaining e
Clan	GH-B
3D Structure Status	β-jelly roll
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Many members have been assigned to subfamilies as described by Viborg et al. (2019) J Biol Chem. 2019 Sep 9 (PMID: 31501245).
External resources	CAZypedia; HOMSTRAD; PRINTS; PROSITE; XTH-World;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1132); Uniprot accession (70); PDB accession (44); 3D entries (22); cryst (1)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
endo-β-1,3-glucanase (LamA; PF0076) (Lam16)	3.2.1.39	Pyrococcus furiosus DSM 3638	AAC25554.2 AAL80200.1 NP_577805.1	E7FHE7 O73951	2VY0[A,B] 2.16	3
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
lichenase A / laminarinase (LicA) (Lic16A)	3.2.1.6 3.2.1.39 3.2.1.73	Acetivibrio thermocellus DSM 1237	CAA61884.2	Q59328	cryst	3
O-glycan endo-β-1,4-galactosidase (Amuc_0724)	3.2.1.-	Akkermansia muciniphila ATCC BAA-835	ACD04561.1 QTD81353.1	A0A2N8IRP0 B2UQ26	6T2N[AAA,BBB]	3
laminarinase (LamAQ)	3.2.1.39	Aquimarina sp. SCSIO21287	QTJ02336.1 CAB3219765.1	A0A6F9D674 A0A8A6LZD2	6JH5[A] 1.54 6JHJ[A] 1.69 6JIA[A] α-L-Altp-(1-3)-β-D-Allp-(1-3)-β-D-Glcp-(1-3)-α-D-Glcp 1.90 6M6P[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp 2.27	3
MLG endo-β-1,4-glucosidase (CapGH16_3;HUK09_00025)	3.2.1.-	Bacteroidaceae bacterium	MCF0235111.1		8VA4[A] 1.96	3
O-glycan endo-β-1,4-galactosidase (BACCAC_02680; CGC64_00690)	3.2.1.-	Bacteroides caccae ATCC 43185	ASM64645.1	A5ZIF0	6T2O[AAA,BBB] 6T2P[AAA,BBB] 6T2Q[AAA,BBB]	3
O-glycan endo-β-1,4-galactosidase (BACCAC_03717; CGC64_17650)	3.2.1.-	Bacteroides caccae ATCC 43185	ASM67518.1	A0A174TK78	6T2R[AAA]	3
O-glycan endo-β-1,4-galactosidase (BF4060)	3.2.1.-	Bacteroides fragilis NCTC 9343	CAH09734.1	A0A380YTM4 A0A3E5CV05 Q5L859	6T2S[AAA,BBB,CCC]	3
β-1,3-1,4-glucanase (BoGH16MLG; BACOVA_02741; Bovatus_03149)	3.2.1.-	Bacteroides ovatus ATCC 8483	ALJ47757.1 EDO11532.1	A0A1Y4PXW9 A7LY25	5NBO[A,B] 1.80 5NBP[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-β-D-Glcp 1.80 6VHO[AAA,BBB] 7KR6[A]	3
β-1,3-glucanase II (BglII)	3.2.1.39	Cellulosimicrobium cellulans LL-G109 / DSM10297 / DK-1	AAC38290.1 AAB39377.1 AAB39378.1 AAB47151.1 AAB47152.1 AAB47153.1 AEK80404.1 EU589324	G1ED17 O68641	3ATG[A] 1.66	3
laminarinase / β-1,3-glucanase (ULam111)	3.2.1.39	Flavobacterium sp. UMI-01	BAX84062.1	A0A1Y1CVU5	5WUT[A,B] 1.60	3
β-1,3-glucanase F (BglF)	3.2.1.39	Nocardiopsis sp. F96	BAE54302.1	Q2V0H0	2HYK[A] 1.30	3
ORF		Pedobacter sp.			7WWC[A] β-D-Glcp-(1-3)-β-D-Glcp β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp 2.20 7WW4[A] 2.23	3
exo-β-1,3-glucosidase / exo-laminarinase (PtLam; TBK1r_73780; BglA)	3.2.1.58	Planctomycetes bacterium TBK1r	QDV88346.1		8XPH[A,B] 2.20 8XPK[A,B] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-α-D-Glcp 2.00 8XPW[A,B] 2.65	3
laminarinase (LamR)	3.2.1.6 3.2.1.39	Rhodothermus marinus ITI278	AAC69707.1	O52754	3ILN[A,B] 1.95	3
endo-β-1,3-glucanase (Curd1;Curd2;Curd3)	3.2.1.39	Streptomyces sioyaensis	AAF31438.1	Q9L816	3DGT[A] 1.50	3
laminarinase (Lam; TmLam; TM0024) (Lam16)	3.2.1.39	Thermotoga maritima MSB8	AAD35118.1 AGL48947.1 AHD18205.1 AKE27833.1 NP_227840.1	Q9WXN1 R4NXC3	3AZX[A,B] 1.80 3AZY[A,B,C,D] 1.65 3AZZ[A,B,C,D] α-D-Glcp β-D-Glcp 1.81 3B00[A,B,C,D] 1.74 3B01[A,B,C,D] 1.87	3
endo-β-1,3-glucanase / laminarinase (Lam;TpLam;Tpet_0899)	3.2.1.39	Thermotoga petrophila RKU-1	ABQ46917.1	A5IL44	4DFS[A,B] 3.75	3
endo-β-1,3-glucanase (partial)	3.2.1.39	uncultured Actinomycetes bacterium	UUY86279.1		7EO3[A] 1.14	3
endo-b-(1,3/1,3;1,4)-glucanase (SCLam) (partial)	3.2.1.6	uncultured bacterium	AJF39933.1	A0A0B5H9B3	6XOF[A] 1.50 6XQF[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp 1.58 6XQG[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp 2.15 6XQH[A] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp 1.57 6XQL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp 1.97 6XQM[A] α-D-Glcp β-D-Glcp-(1-3)-α-D-Glcp 1.85	3
laminarinase (LamC; ZgLamC; ZgLamCGH16; zobellia_1010)	3.2.1.39	Zobellia galactanivorans DsijT	CAZ95067.1	G0L2L9	4CRQ[A,B] 1.50 4CTE[A,B] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp1SH β-D-Glcp-(1-3)-β-D-Glcp1SH 1.80	3
algal laminarin-specific β-glucanase / laminarinase (LamA; ZgLamA; zobellia_2431)	3.2.1.39	Zobellia galactanivorans DsijT	CAZ96583.1	G0L5X4	4BOW[A,B] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-α-D-Glcp β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp 1.35 4BPZ[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp 1.13 4BQ1[A,B] 1.50	3
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