Glycoside Hydrolase Family 168

Mechanism	Retaining (inferred) e
3D Structure Status	( β / α ) ₈ barrel
Note	Family created after the demonstration of the endo-1,3-fucanase activity of the FunA protein (AXE80_10060) of Wenyingzhuangia fucanilytica by Shen et al., Frontiers in Microbiology (2020). FunA also displayed a transglycosidase activity.
External resources	CAZypedia;
Statistics	GenBank accession (108); Uniprot accession (7); PDB accession (13); 3D entries (6); cryst (0)

Bacteria

Protein Name

EC#

Organism

GenBank

Uniprot

PDB/3D

Carbohydrate Ligands

Resolution (Å)

MeGH168 / AAY42_01205

KQC28672.1
WP_055392190.1

2.00

endo-α-1,3-L-fucanase (Pb41GH168_IV; Poly41_55130)

TWU32535.1
WP_146530294.1

9JOS[A]		1.70
9JP2[A]	α-L-Fucp-(1-3)-α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp2SO3-(1-3)-α-L-Fucp2SO3	2.02
9JP3[A]	α-L-Fucp2SO3-(1-3)-α-L-Fucp-(1-3)-α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp2SO3	1.40

Rho5174 / RRSWK_04259

1.57

endo-α-1,3-L-fucanase 168A (FunA; Fun168A_Wf; AXE80_10060) (Fun168A)

ANW96599.1
WP_068826898.1
WP_068826898.1

8YA6[A]		1.92
8YA7[A]	α-L-Fucp-(1-3)-α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp2SO3-(1-3)-α-L-Fucp2SO3	1.99

endo-α-1,3-L-fucanase (WfGH168_I; Fun168E; AXE80_08855) (Fun168E)

ANW96379.1
WP_068826442.1
WP_169816820.1

9JOM[A]		2.04
9JOO[A]	α-L-Fucp2SO3-(1-3)-α-L-Fucp-(1-3)-α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp2SO3	1.97

endo-α-1,3-L-fucanase (WfGH168_II; FUN168D; AXE80_08865)

ANW96381.1
WP_068826447.1

9JOC[A]		1.29
9JOF[A,B]	α-L-Fucp-(1-3)-α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp2SO3	1.50
9JOG[A,B]	α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp-(1-3)-α-L-Fucp2SO3-(1-3)-α-L-6-deoxy-Gulp2SO3 α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp-(1-3)-α-L-Fucp2SO3-(1-3)-α-L-Fucp2SO3	1.40
9JOH[A,B]	α-L-Fucp2SO3-(1-3)-α-L-Fucp-(1-3)-α-L-Fucp2SO34SO3-(1-3)-α-L-Fucp2SO3	1.36