Mechanism	Retaining a
Clan	GH-H
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	New: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resources	CAZypedia; EBI Protein of the Month; PDB Molecule of the Month;
Statistics	GenBank accession (8); Uniprot accession (16); PDB accession (18); 3D entries (3); cryst (0)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
α-amylase / maltooligosyltrehalose trehalohydrolase (GTHase)	3.2.1.1 3.2.1.141	Saccharolobus solfataricus KM1	AAR46454.1 BAA11010.1	Q55088	1EH9[A] 3.00 1EHA[A] 3.00 3VGB[A] 2.65 3VGD[A] 2.40 3VGE[A] 2.70 3VGF[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.30 3VGG[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-3)-α-D-Glcp 2.66 3VGH[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-1)-α-D-Glcp 2.60	10
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
malto-oligosyltrehalose trehalohydrolase (TreZ; DrMTHase; DR0464)	3.2.1.141	Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539	AAF10042.1 ANC72786.1 NP_294187.1	Q9RX51	2BHU[A] 1.1 2BHY[A] α-D-Glcp α-D-Glcp-(1-1)-α-D-Glcp 1.5 2BHZ[A] α-D-Glcp-(1-4)-β-D-Glcp 1.2 2BXY[A] α-D-Glcp α-D-Glcp-(1-1)-α-D-Glcp β-D-Glcp 1.75 2BXZ[A] α-D-Glcp α-D-Glcp-(1-1)-α-D-Glcp β-D-Glcp 1.75 2BY0[A] α-D-Glcp-(1-1)-α-D-Glcp β-D-Glcp 1.55 2BY1[A] α-D-Glcp-(1-1)-α-D-Glcp β-D-Glcp 1.55 2BY2[A] α-D-Glcp α-D-Glcp-(1-1)-α-D-Glcp β-D-Glcp 1.5 2BY3[A] α-D-Glcp-(1-1)-α-D-Glcp β-D-Glcp 1.5	10
STM1560		Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	AAL20478.1 NP_460519.1		3M07[A] 1.40	10
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