Mechanism	Retaining e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
Note	Created after (Sumida et al., 2011) [PMID: 21297160]. Subfamilies established according to both (Moreno Prieto et al., 2024) [PMID:38129294] and (Sumida et al., 2024) [PMID:38730244]. In the latter, group 1 is GH123_4; group 2 is GH123_5; group 3 is GH123_3; group 4 is GH123_2 and group GH123 is GH123_1.
External resources	CAZypedia;
Statistics	GenBank accession (1993); Uniprot accession (11); PDB accession (19); 3D entries (8); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
glycolipid exo-β-N-acetylgalactosaminidase (CpNga123; CPF_1473)	3.2.1.53 3.2.1.-	Clostridium perfringens ATCC 13124	ABG82546.1	A0A0H2YNR7	5FQE[A,B] 1.53 5FQF[A,B] β-D-GalpNAc 2.15 5FQG[A] β-D-GalpNAc-(1-3)-β-D-Galp 2.30 5FQH[A] β-D-GalpNAc-(1-4)-β-D-Galp-(1-4)-β-D-Glcp 2.10 5FR0[A] <non_carb>-(1-2)-β-D-GalpN 1.75	1
β-N-acetylgalactosaminidase (NgaCa; KCTCHS21_21730)	3.2.1.53	Cohnella abietis HS21	BBI32774.1	A0A3T1D3V8	8K2F[A] 1.75 8K2G[A,B] 1.75	4
exo-β-N-acetylgalactosaminidase (NgaLy)	3.2.1.- 3.2.1.-	Lacticaseibacillus yichunensis	WP_125696777.1	A0AAT8XUB5	8K2N[A,B,C,D] 2.50	2
β-N-acetylgalactosaminidase (NaNga) (DUF4091 domain-containing protein)	3.2.1.53	Niabella aurantiaca DSM 17617	WP_018628640.1	A0AAJ6N6J1 A0AAT8XUD7	8P4L[A,B,C,D,E,F,G,H,I,J, 2.79 8Q8H[A,B,C,D] 2.50	2
exo-β-N-acetylgalactosaminidase (NgaP2)	3.2.1.- 3.2.1.-	Paenibacillus sp. TS12	BEL01682.1	A0AAT8XUB3	8K2L[A] 1.95 8K2M[A] D-1,2-deoxy-Galp 1.65	2
N-acetyl-β-galactosaminidase / β-N-acetylgalactosaminidase (BvGH123; BVU_2198)	3.2.1.53	Phocaeicola vulgatus ATCC 8482	ABR39859.1	A6L2E5	5L7R[A,B] 1.85 5L7U[A,B] β-D-GalpNAc 2.10 5L7V[A,B] D-1,2-deoxy-Galp 2.30	1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
exo-β-1,3-N-acetylgalactosaminidase (NgaAt)	3.2.1.-	Arabidopsis thaliana	AEE32084.1 Q7Y231		8K2H[A,B] D-1,2-deoxy-Galp 2.20 8K2I[A,B] 2.50	5
unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
β-N-acetylgalactosaminidase (NgaDssm; DSSM_3)	3.2.1.53 3.2.1.-	unidentified			8K2J[A] 1.76 8K2K[A] D-1,2-deoxy-Galp 1.75	3
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