Glycoside Hydrolase Family 123

Mechanism	Retaining e
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
Note	Created after (Sumida et al., 2011) [PMID: 21297160]. Subfamilies established according to both (Moreno Prieto et al., 2024) [PMID:38129294] and (Sumida et al., 2024) [PMID:38730244]. In the latter, group 1 is GH123_4; group 2 is GH123_5; group 3 is GH123_3; group 4 is GH123_2 and group GH123 is GH123_1.
External resources	CAZypedia;
Statistics	GenBank accession (1993); Uniprot accession (11); PDB accession (19); 3D entries (8); cryst (0)

Activity Id	EC#	Activity Name	Residue -2	Bond -1	Residue -1	Reacting Bond	Residue +1	Bond +1	Residue +2	Reactant
H39	3.2.1.53	b-N-acetylgalactosaminidase			[bDGalpNAc	1,X	alcohol			H2O
H200	3.2.1.-	glycosphingolipid exo-b-1,4-N-acetylgalactosaminidase			[bDGalpNAc	1,4	bDGalp	1,4	bDGlcp	H2O
H399	3.2.1.-	exo-b-1,3-N-acetylgalactosaminidase			[bDGalpNAc	1,3	aDGalp	1,4	bDGalp	H2O
H400	3.2.1.-	exo-b-1,4-N-acetylgalactosaminidase			[bDGalpNAc	1,4	bDGalp	1,4	bDGlcp	H2O
H401	3.2.1.-	b-N-acetyl-4-sulfo-galactosaminidase			[bDGalpNAc_4S	1,X	alcohol			H2O
H402	3.2.1.-	endo-b-1,4-N-acetylgalactosaminidase	bDGalp	1,3	bDGalpNAc	1,4	bDGalp	1,4	bDGlcp	H2O
H403	3.2.1.-	endo-b-1,3-N-acetylgalactosaminidase	bDGalp	1,3	bDGalpNAc	1,3	aDGalp	1,4	bDGalp	H2O
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