Mechanism	Retaining e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
Note	Created after (Sumida et al., 2011) [PMID: 21297160]. Subfamilies established according to both (Moreno Prieto et al., 2024) [PMID:38129294] and (Sumida et al., 2024) [PMID:38730244]. In the latter, group 1 is GH123_4; group 2 is GH123_5; group 3 is GH123_3; group 4 is GH123_2 and group GH123 is GH123_1.
External resources	CAZypedia;
Statistics	GenBank accession (480); Uniprot accession (5); PDB accession (5); 3D entries (3); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
exo-β-N-acetylgalactosaminidase (NgaLy)	3.2.1.- 3.2.1.-	Lacticaseibacillus yichunensis	WP_125696777.1	A0AAT8XUB5	8K2N[A,B,C,D] 2.50	2
β-N-acetylgalactosaminidase (NaNga) (DUF4091 domain-containing protein)	3.2.1.53	Niabella aurantiaca DSM 17617	WP_018628640.1	A0AAJ6N6J1 A0AAT8XUD7	8P4L[A,B,C,D,E,F,G,H,I,J, 2.79 8Q8H[A,B,C,D] 2.50	2
exo-β-N-acetylgalactosaminidase (NgaP2)	3.2.1.- 3.2.1.-	Paenibacillus sp. TS12	BEL01682.1	A0AAT8XUB3	8K2L[A] 1.95 8K2M[A] D-1,2-deoxy-Galp 1.65	2
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