Activities in Family	Modules of approx. 50 residues found attached to various enzymes from families GH18, GH19, GH23, GH24, GH25 and GH73, i.e. enzymes cleaving either chitin or peptidoglycan. Binding to chitopentaose demonstrated in the case of Pteris ryukyuensis chitinase A [Ohnuma T et al. (2008) J. Biol. Chem. 283:5178-87 (PMID: 18083709)]. CBM50 modules are also found in a multitude of other enzymes targeting the petidoglycan such as peptidases and amidases. These enzymes are not reported in the list below.
Note	Also known as LysM domains
External resources	CAZypedia;
Statistics	GenBank accession (148509); Uniprot accession (16); PDB accession (42); 3D entries (29); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Cthe_0300		Acetivibrio thermocellus ATCC 27405	ABN51538.1		7R1L[A,B,C] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.45
cortex-lytic enzyme SleL		Bacillus cereus ATCC 10876	KFL63465.1		4S3J[A] 1.60
cortex-lytic enzyme SleL		Bacillus cereus ATCC 10876	KFL63465.1		4S3J[A] 1.60
HIR78_05275 (LytE)		Bacillus subtilis subsp. subtilis str. 168	QJP87462.1		8I2E[B,D] 3.20
HIR78_05275 (LytE)		Bacillus subtilis subsp. subtilis str. 168	QJP87462.1		8I2E[B,D] 3.20
HIR78_05275 (LytE)		Bacillus subtilis subsp. subtilis str. 168	QJP87462.1		8I2E[B,D] 3.20
BSU14040 (YkuD)		Bacillus subtilis subsp. subtilis str. 168	CAA10867.1 CAB13277.1		1Y7M[A,B] 2.05 2MTZ[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc NMR 3ZQD[A] NMR 4A1I[A,B,C,D,E,F,G,H] 1.76 4A1J[A,B] 2.20 4A1K[A] 1.75 4A52[A] <carb_like_IM2> NMR
N-acetylglucosaminidase (AtlA; EF0799; EF_0799)		Enterococcus faecalis V583	AAO80613.1 AAR60023.1 NP_814543.1	P37710	2MKX[A] NMR
QR62_09075		Escherichia coli K-12	ALI44012.1		5FIM[A] NMR 7PVC[A] NMR
GRF62_14135 (KbP)		Escherichia coli K-12	QHB68149.1		7VCM[A,B] 1.85
lytic transglycosylase (MltD; b0211)		Escherichia coli str. K-12 substr. MG1655	AAC73316.1 AAB08633.1 AIZ92633.1 ALI41971.1 AMC97457.1 AUG15008.1 AVI54749.1 AYG20637.1 NP_414747.1		1E0G[A] NMR
spore cortex-specific N-acetylglucosaminidase (SleL;YaaH;BMQ_0021)		Priestia megaterium QM B1551	ADE67156.1 ABS32202.1 YP_003560590.1		4S3K[A] 1.70
spore cortex-specific N-acetylglucosaminidase (SleL;YaaH;BMQ_0021)		Priestia megaterium QM B1551	ADE67156.1 ABS32202.1 YP_003560590.1		4S3K[A] 1.70
NCTC9433_03378 (Mltd_1)		Pseudomonas aeruginosa NCTC9433	SQK97194.1		8RHE[A,B] β-D-GlcpNAc4SO3-(1-1)-<non_carb> 1.95 8RHF[A,B] β-D-GlcpNAc4SO3-(1-1)-<non_carb> 1.95 8RHI[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc4SO3-(1-1)-<non_carb> 1.98
D,L-endopeptidase (NlpC/P60;P60_tth;TTHA0266)		Thermus thermophilus HB8	BAD70089.1		4UZ2[A,B,C,D] 2.50 4UZ3[A,B,C] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.75 4XCM[B] 2.65
D,L-endopeptidase (NlpC/P60;P60_tth;TTHA0266)		Thermus thermophilus HB8	BAD70089.1		4UZ2[A,B,C,D] 2.50 4UZ3[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.75 4XCM[A,B] 2.65
F0316_17325		Vibrio cholerae RFB16	QEO43340.1		6U2A[A] 2.30 6UE4[A,B] 2.08
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
chitinase A (EaChiA)		Equisetum arvense	BAI22848.1	C7G3I3	5BUM[A,B] 2.50
LysM effector / extracellular protein 6 (Ecp6)		Fulvia fulva	ACF19427.1		4B8V[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 1.59 4B9H[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 2.10
LysM effector / extracellular protein 6 (Ecp6)		Fulvia fulva	ACF19427.1		4B8V[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 1.59 4B9H[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 2.10
LysM effector / extracellular protein 6 (Ecp6)		Fulvia fulva	ACF19427.1		4B8V[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 1.59 4B9H[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 2.10
LysM type receptor kinase (Lys11)		Lotus japonicus	BAI79275.1		7BAX[A] 2.90
chitin elicitor binding protein (CEBiP;OsCEBiP;Os03g0133400)		Oryza sativa Japonica Group	BAF10789.1 AAN05509.1 ABF93833.1 BAE95828.1 BAG93257.1 BAS82158.1		5JCD[A,B,C] 2.40 5JCE[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.51
chitin elicitor binding protein (CEBiP;OsCEBiP;Os03g0133400)		Oryza sativa Japonica Group	BAF10789.1 AAN05509.1 ABF93833.1 BAE95828.1 BAG93257.1 BAS82158.1		5JCD[A,B,C] 2.40 5JCE[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.51
chitinase A (ChiA;PrChiA)		Pteris ryukyuensis	BAE98134.1	Q0WYK2	4PXV[A,B,C,D] 1.80 5YLG[A,B,C,D] 1.48
lectin (MGG_03307)		Pyricularia oryzae 70-15	EDK00177.1		2L9Y[A] NMR 5C8O[A] 2.09 5C8P[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.20 5C8Q[B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.90
chitinase/lysozyme (VcLysM1;VcLysM2)		Volvox carteri f. nagariensis	AAC13727.1		5YZ6[A] NMR
chitinase/lysozyme (VcLysM1;VcLysM2)		Volvox carteri f. nagariensis	AAC13727.1		5K2L[A] 1.20 5YZK[A] NMR
LysM effector (MYCGRDRAFT_105487)		Zymoseptoria tritici IPO323	XP_003850050.1		6Q40[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.41
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