Activities in Family	Modules of approx. 150 residues found in bacterial enzymes. The cellulose-binding function has been demonstrated in many cases. In one instance binding to chitin has been reported.
3D Structure Status	β-sandwich
Note	Previously known as cellulose-binding domain family III (CBD III).
External resources	CAZypedia; PROSITE;
Statistics	GenBank accession (3480); Uniprot accession (140); PDB accession (42); 3D entries (22); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
scaffoldin A (ScaA;CipV)		Acetivibrio cellulolyticus	AAF06064.1		3ZQW[A] 1.07 3ZU8[A] 1.80 3ZUC[A] 1.00
Clocl_1192		Acetivibrio clariflavus DSM 19732	AEV67853.1		6XX1[A,B,C,D] 1.61
Clocl_4008 (Cbm3B)		Acetivibrio clariflavus DSM 19732	AEV70444.1		4B96[A] 1.91
Cthe_0271		Acetivibrio thermocellus ATCC 27405	CAA93151.2 ABN51510.1 CAD12660.1		6SL4[A,B,C] 1.80
scaffoldin (CipA; Cthe_3077)		Acetivibrio thermocellus ATCC 27405	ABN54273.1 AAG15505.1		1NBC[A,B] 1.75 4B9F[A,B] 1.19
broad specificity plant-cell wall carbohydrate-sensor (RsgI1;Cthe_0059)		Acetivibrio thermocellus ATCC 27405	ABN51300.1 CCF82156.1		4B9C[A] 1.17
cellulose-specific sensor (RsgI2;Cthe_0267)		Acetivibrio thermocellus ATCC 27405	ABN51506.1		4B9P[A] 1.18
weak xyloglucan-specific sensor (RsgI4;Cthe_0404)		Acetivibrio thermocellus ATCC 27405	ABN51642.1		4B97[A] 1.28
cellobiohydrolase (CbhA; Cthe_0413) (Cbh9A)		Acetivibrio thermocellus ATCC 27405	ABN51651.1	A3DCH2 Q59325	4C8X[A,B,C,D] 2.00
endo-β-1,4-glucanase R / cellotetraohydrolase (CelR; Cthe_0578) (Cel9R)		Acetivibrio thermocellus ATCC 27405	ABN51814.1	A3DCY5	7UNP[A] 2.00
endo-β-1,4-glucanase (CelV; Cthe_2760) (Cel9V)		Acetivibrio thermocellus ATCC 27405	ABN53959.1		2WNX[A] 1.31 2WO4[A] 1.85 2WOB[A,C,E] 2.00
endoglucanase Q (CelQ) (Cel9I)		Acetivibrio thermocellus F1	BAB33148.1	Q9AJF8	5GXX[A,B] 1.50 5GXY[A,B] β-D-Glcp-(1-4)-β-D-Glcp 1.70 5GXZ[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.05 5GY0[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.74 5GY1[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.99
cellobiohydrolase A (CbhA) (Cbh9A)		Acetivibrio thermocellus F7	CAA56918.2 CAA56918.1	Q59325	2YLK[A,B,C,D] 2.20 3ZQX[A] 1.04
endo-β-1,4-glucanase I (CelI;CMC) (Cel9C=Cel9I)		Acetivibrio thermocellus NCIB10682 / F7	AAA20892.1 CAB76932.1	Q02934 Q9L3J8	2XFG[B] 1.68
scaffoldin (CipA;YSBL_2973) (partial)		Acetivibrio thermocellus YS	EIC03335.1		4JO5[A] 1.98
multifunctional glycoside hydrolase (Cdan_2053; SOJ16_001858)		Anaerocellum danielii	WP_045175321.1 WPX08008.1	A0A4V8GZQ9 A0ABZ0U049	6D5B[A,B,C,D,E,F,G,H,I,J, 2.00
endoglucanase (BLi01880;BL01232;BlCel9)		Bacillus licheniformis DSM 13 = ATCC 14580	AAU40775.1 AAU23415.1	Q65JI9	8U49[A] 1.80 8U4A[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.97 8U4F[A] β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp 2.01
endo-β-1,4-glucanase (EglS; BglC; Gld; BsCel5; BsCel5A; BSU18130) (Cel5A)		Bacillus subtilis subsp. subtilis str. 168	CAA82317.1 AEJ76923.1 AIY93123.1 AQR81804.1 AQR86018.1 CAA97610.1 CAB13696.2 NP_389695.1 NP_389695.2	A0A6M3ZBL5 G1DE47 P10475	2L8A[A] NMR 6UFV[A] 1.06 6UFW[A] 1.28
scaffoldin (ScaA;Cipbc)		Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933	AAG01230.2		2XBT[A] 1.83
endo-β-1,4-glucanase 9G (CelG; Ccel_0731) (Cel9G)		Ruminiclostridium cellulolyticum H10	ACL75110.1 AAA73868.1	P37700	1G87[A,B] 1.60 1GA2[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.70 1K72[A,B] α-D-Glcp β-D-Glcp-(1-4)-α-D-Glcp 1.80 1KFG[A,B] β-D-Glcp4S-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp1S 1.90
scaffoldin (CipC;Ccel_0728)		Ruminiclostridium cellulolyticum H10	ACL75107.1 AAC28899.2		1G43[A] 2.20
endo/exo-β-1,4-glucanase 9A (E4; CelD; TfCel9A; Tfu_2176) (processive) (Cel9A)		Thermobifida fusca YX	AAB42155.1 AAZ56209.1	P26221 Q47MW0	1JS4[A,B] β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.00 1TF4[A,B] 1.90 3TF4[A,B] β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.20 4TF4[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 2.00
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