Activities in Family	Pyranose:oxygen 2-oxidoreductase / glucose 2-oxidase (EC 1.1.3.10); Alcohol oxidase (EC 1.1.3.13); Ecdysone oxidase (EC 1.1.3.16); Glucose 1-oxidase (EC 1.1.3.4); Aryl alcohol oxidase (EC 1.1.3.7); Oligosaccharide dehydrogenase (FAD) (EC 1.1.5.-); Glucose 1-dehydrogenase (FAD, quinone) (EC 1.1.5.9); Cellobiose dehydrogenase (EC 1.1.99.18); Pyranose dehydrogenase (EC 1.1.99.29);
Note	AA3 enzymes belong to the glucose-methanol-choline (GMC) oxidoreductases family. AA3 enzymes are flavoproteins containing a flavin-adenine dinucleotide (FAD)-binding domain. Family AA3 can be divided into 4 subfamilies: AA3_1 (mostly cellobiose dehydrogenases), AA3_2 (including both aryl alcohol oxidase and glucose 1-oxidase), AA3_3 (alcohol oxidase) and AA3_4 (pyranose 2-oxidase).
External resources	CAZypedia;
Statistics	GenBank accession (4183); Uniprot accession (50); PDB accession (61); 3D entries (20); cryst (1)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Resolution (Å)	Subf
glucose dehydrogenase (GDH,G4B84_001660)	1.1.5.9	Aspergillus flavus NRRL3357	QMW26415.1	A0A1S9DW10 B8MX95	4YNT[A] 1.78 4YNU[A] 1.57 7VKD[A] 1.58 7VZP[A,B] 1.20 7VZS[A,B] 1.80	2
glucose oxidase (Gox1; AnGOx)	1.1.3.4	Aspergillus niger NRRL-3	AAA32695.1 AAB12628.1 AAQ78793.1 ACB30369.1 CAA34197.1 CAC27315.1 CAC83816.1	B2CNX8 P13006 Q5Q041	1CF3[A] 1.90 1GAL[A] 2.30 3QVP[A] 1.20 3QVR[A] 1.30 5NIT[A] 1.87 5NIW[A] 1.80 8JPZ[A,B] 2.08	2
AO090012000349		Aspergillus oryzae RIB40	BAE60539.1		5ZU3[A,B,C] 2.40	2
aryl alcohol oxidase	1.1.3.7	Bjerkandera adusta			9AVH[A] 1.80	2
cellobiose dehydrogenase IIA (Cdh;MtCDH)	1.1.99.18	Crassicarpon hotsonii	ABS45567.2 ABS45566.1	A9XK87 A9XK88	4QI4[A] 2.70 4QI5[A] 2.40 4QI6[A] 3.20	1
alcohol oxidase / methanol oxidase (Aox1;AOX1;MOX1)	1.1.3.13	Komagataella pastoris NRRL Y-11430	AAB57849.1	F2QY27 P04842	5HSA[A,B,C,D,E,F,G,H] 2.35 5I68[A] 3.37	3
pyranose dehydrogenase (Pdh1; PDH; AmPDH)	1.1.99.29	Leucoagaricus meleagris	AAW82996.1 AAW82997.1	Q3L245	4H7U[A] 1.60	2
cellobiose dehydrogenase IIA (Cdh-1;CDH-1;CdhIIA;Nc-Cdh1;NCU00206)	1.1.99.18	Neurospora crassa OR74A	EAA27355.1 XP_322292.1	Q7RXM0	4QI7[A,B] 2.90	1
glucose oxidase	1.1.3.4	Penicillium amagasakiense		P81156	1GPE[A,B] 1.80	2
pyranose 2-oxidase / glucose 2-oxidase	1.1.3.10	Peniophora sp. SG	AAO13382.1	Q8J136	1TZL[A,B,C,D,E,F,G,H] 2.35 2F5V[A] 1.41 2F6C[A] 1.84	4
pyranose 2-oxidase (PoX)	1.1.3.10	Phanerochaete chrysosporium BKM-F-1767	AAS93628.1 Q6QWR1.1	Q6QWR1	4MIF[A,B,C,D] 1.80 4MIG[A,B,C,D] 1.80 4MIH[A,B,C,D,E,F,G,H] 2.40	4
alcohol oxidase (Aox1)	1.1.3.13	Phanerochaete chrysosporium DSMZ 1547	CDG66232.1	T2M2J4	6H3G[A,B,C,D,E,F,G,H] 2.60 6H3O[A,B,C,D,E,F,G,H] 2.50 8IL5[A,B] 2.50	3
cellobiose dehydrogenase (CdH)		Phanerochaete chrysosporium OGC101	AAC49277.1		1KDG[A,B] 1.50 1NAA[A,B] 1.80	1
aryl-alcohol oxidase (AaO; PeAAOX)	1.1.3.7	Pleurotus eryngii ATCC90787; CBS 613.91; IJFM A169	AAC72747.1	O94219	3FIM[B] 2.55 5OC1[A] 2.30	2
aryl-alcohol oxidase (AaO; PpAAox)	1.1.3.7	Pleurotus pulmonarius CBS 507.85	AAF31169.1	Q9P928	cryst	2
K466DRAFT_604656		Polyporus arcularius HHB13444	TFK81242.1		8IL4[A,B,C,D] 3.36	3
FAD-dependent oxidoreductase (CTHT_0048040)		Thermochaetoides thermophila DSM 1495	EGS19346.1		6ZE2[A,B] 1.31 6ZE3[A] 2.22 6ZE4[A,B] 1.60 6ZE5[A,B] 1.82 6ZE6[A,B] 1.26 6ZE7[A,B] 1.50 7AA2[A,B] 1.40	2
aryl-alcohol oxidase (MYCTH_2299749)		Thermothelomyces thermophilus ATCC 42464	XP_003660923.1		6O9N[A,B] 2.60	2
oligosaccharide dehydrogenase (active on β-1,3 and β-1,3-1,4-gluco-oligosaccharides) (ODH; BN946_scf184803.g17)	1.1.5.-	Trametes cinnabarina BRFM137	CDO69819.1	A0A060SC37	6XUT[A] 1.60 6XUU[A] 1.57 6XUV[A] 1.75	2
pyranose 2-oxidase (P2O;TmP2O)	1.1.3.10	Trametes ochracea MB49	AAP40332.1	Q7ZA32	4MOE[A,B,C,D] 2.00 4MOF[A] 1.85 4MOG[A] 2.00 4MOH[A] 2.10 4MOI[A,B] 1.90 4MOJ[A,B,C,D] 2.00 4MOK[A,B,C,D] 1.90 4MOL[A,B,C,D] 2.00 4MOM[A,B,C,D] 1.90 4MOO[A] 1.65 4MOP[A,B,C,D] 2.30 4MOQ[A,B] 1.60 4MOR[A,B,C,D] 1.50 4MOS[A] 1.80	4
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