What’s new

This section provides news on changes in CAZy interface, content, and related resources.

July 2024

addition : 17 septembre 2024.

This month, we officialized two novel GT families, GT136 and GT137, both discovered by the Wihtfield lab, which exhibit original/rare activities : α-pentose and α-Kdo transferases.
We also created two additional subfamilies for GH13 family, following a bioinformatics analysis by the Janecek lab (to be published in Applied Microbiology and Biotechnology).
These subfamilies, GH13_48 and GH13_49, have been characterized some time ago already, but this analysis highlight their conservation pattern and evolutionary relatedness, as well as another group not characterized to date which could become another subfamily in the future.

May 2024

addition : 11 juillet 2024.

After an amazing CBM15 conference in Ghent (Belgia), this month, we officialized two novel CBM families, CBM102 and CBM103, both with laminarin-binding members described by Zühlke and coworkers.
We also implemented the division into subfamilies of the GH123 family.
This was done according to the initial presentation of the two first subfamilies last year by Moreno Prieto and coworkers, recently completed by two additional subfamilies by Sumida and coworkers.
However, please note that their group numbering do not correspond to the subfamily numbering : group 1 is GH123_4 ; group 2 is GH123_5 ; group 3 is GH123_3 ; group 4 is GH123_2 and group GH123 is GH123_1).
Most of these subfamilies (apart GH123_1) were previously classified as GH_nc given their weak signals of homology to characterized GH123(_1) members.

March & April 2024

addition : 11 juillet 2024.

This month, we would like to highlight 17 bacterial polysaccharide polymerase families, GT119 to GT135, long-overdue but which required in-depth sequence analyses realized by Meitil and coworkers.

February 2024

addition : 22 mars 2024.

This month, we are welcoming a novel GH family, GH189 after the functional and structural characterization by Tanaka et al. (PMID=38300345) of a transglycosidase activity for a module belonging to this family, distantly related to GH144 and GH162. This team also recently deposited a manuscript to bioRxiv about this superfamily. GH189 distinguished by being systematically part of a trimodular proteins involved in the cyclic β-1,2-glucan syntesis pathway, for which another nice manuscript could be found in bioRxiv.

We also released a new GT family, GT118, discovered by Walklett et al. (PMID=38224120), as well as 17 bacterial polysaccharide polymerase families, GT119 to GT135, long-overdue but which required in-depth sequence analyses, to be published in Communications Biology by Meitil and coworkers.

The January 2024 update of CAZy CAZy wishes...

addition : 23 février 2024.

CAZy wishes you a wonderful 2024 year, healthy and full of discoveries !!!
We would like to start this year by a big thank to CAZypedia contributors and organizers, as the lastly released families, described below, already have CAZypedia pages !

This month, we are welcoming a novel GH family, GH188 after the discovery of a NAD+ dependent sulfoquinovosidase active enzyme by Kaur et al. (PMID=38100472).
We also released another CBM family, CBM101 (Mei et al. ; PMID=38010608, discovered by the same laboratory who recently contributed CBM99, CBM100 and GH187.

Also, for those who missed it : end of 2023, we released on CAZy.org our expert annotation of the eukaryotic genomes sequenced by JGI after publication, including both MycoCosm and PhycoCosm projects ! This huge annotation effort is accomplished by Bernard and Elodie. We hope you’ll appreciate it.