Polysaccharide Lyase Family 21

Activities in FamilyAcharan-sulfate lyase (EC 4.2.2.-);
Heparin lyase / heparin lyase I (EC 4.2.2.7);
Heparin-sulfate lyase / heparin lyase III (EC 4.2.2.8);
Mechanism b-elimination
3D Structure Status( α / α ) 6 toroid + anti-parallel β-sheet
Noteheparin lyase II enzymes have simultaneously heparin lyase (heparin lyase I) and heparin-sulfate lyase (heparin lyase III) activity ; distantly related to family PL15;
Statistics GenBank accession (88); Uniprot accession (3); PDB accession (4); 3D entries (1); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 acharan sulfate lyase 1/2 / heparin lyase II / heparanase II (AlsI;Als2;HepII) 4.2.2.- pubmed
Bacteroides stercoris HJ-15 ACN29695.1 C0JBW5   1
 heparin lyase II / heparinase II (HepB;Phep_2408) 4.2.2.7
4.2.2.8
pubmed
pubmed
Pedobacter heparinus DSM 2366 ACU04612.1
AAB18277.1
ABJ17170.1
ACW20418.1
C6XZB6
Q46080
2FUQ[A,B]
2FUT[A,B]
3E7J[A,B]
3E80[A,B,C]
1
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