Activities in Family	Acharan-sulfate lyase (EC 4.2.2.-); Heparin lyase / heparin lyase I (EC 4.2.2.7); Heparin-sulfate lyase / heparin lyase III (EC 4.2.2.8);
Mechanism	b-elimination
3D Structure Status	( α / α ) 6 toroid + anti-parallel β-sheet
Note	heparin lyase II enzymes have simultaneously heparin lyase (heparin lyase I) and heparin-sulfate lyase (heparin lyase III) activity ; distantly related to family PL15;
Statistics	GenBank accession (94); Uniprot accession (3); PDB accession (4); 3D entries (1); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
heparin lyase II / heparinase II (HepB;Phep_2408)	4.2.2.7 4.2.2.8	Pedobacter heparinus DSM 2366	ACU04612.1 AAB18277.1 ABJ17170.1 ACW20418.1	C6XZB6 Q46080	2FUQ[A,B] 2.15 2FUT[A,B] α-L-4-deoxy-IdopA2SO3-(1-4)-α-D-GlcpNSO36SO3 β-D-4-deoxy-GlcpA2SO3-(1-4)-α-D-GlcpNSO36SO3 2.30 3E7J[A,B] α-L-4-deoxy-IdopA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-β-D-GlcpNAc β-D-4-deoxy-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-β-D-GlcpNAc 2.10 3E80[A,B,C] α-L-4-deoxy-IdopA-(1-4)-α-D-GlcpNAc β-D-4-deoxy-GlcpA-(1-4)-α-D-GlcpNAc 2.35	1
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