Polysaccharide Lyase Family 16

Activities in Familyhyaluronan lyase (EC 4.2.2.1).
Mechanism b-elimination
3D Structure Statustriple strand β-helix
NoteFormerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657. Subfamilies have been deleted in this family (December 2012).
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (435); Uniprot accession (5); PDB accession (14); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 hyaluronate lyase (HylP2) 4.2.2.1 Streptococcus pyogenes 10403 AAA86895.1 Q54699
Q9A0M7
2DP5[A] 3.55
3EKA[A] α-L-Gulf
3.10
 hyaluronan lyase (HylP3)   Streptococcus pyogenes M1 GAS AAK34249.1
NP_269528.1
 
2WB3[A] 1.90
 hyaluronate lyase (HylP2)   Streptococcus pyogenes M1 GAS AAK33900.1
NP_269179.1
 
2WH7[A] 1.60
 hyaluronate lyase (HylP1;SPy0701) 4.2.2.1 Streptococcus pyogenes M1 GAS AAK33657.1
NP_268936.1
Q9A0M7
2C3F[A] 1.81
2PK1[A] α-L-Gulf
3.10
2YVV[A] β-D-Galp-(1-4)-α-D-Glcp
2.60
2YW0[A] 2.60
2YX2[A] 2.80
 hyaluronidase (Hyal_Sk) 4.2.2.1 Streptomyces koganeiensis ATCC 31394 AKQ62598.1 A0A0U2E2J7
A0A182DVL8
4UFQ[A,B] 1.45
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 hyaluronate lyase (HylP1;HylP) 4.2.2.1 Streptococcus pyogenes phage H4489A AAA98101.1 P15316
6WV2[A,B,C] 2.21
6WWX[A,B,C] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.20
6WXA[A,B,C] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.30
6X3M[A,B,C,D,E,F,G,H,I] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-D-1-deoxy-GlcpNAc
α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-D-1-deoxy-GlcpNAc
β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
3.58
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