Activities in Family	Hyaluronate lyase (EC 4.2.2.1);
Mechanism	b-elimination
3D Structure Status	triple strand β-helix
Note	Formerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657. Subfamilies have been removed in this family (December 2012).
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (435); Uniprot accession (3); PDB accession (13); 3D entries (5); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
hyaluronate lyase (HylP2)	4.2.2.1	Streptococcus pyogenes 10403	AAA86895.1	Q54699 Q9A0M7	2DP5[A] 3.55 3EKA[A] α-L-Gulf 3.10
hyaluronan lyase (HylP3)		Streptococcus pyogenes M1 GAS SF370	AAK34249.1 NP_269528.1		2WB3[A] 1.90
hyaluronate lyase (HylP2)		Streptococcus pyogenes M1 GAS SF370	AAK33900.1 NP_269179.1		2WH7[A] 1.60
hyaluronate lyase (HylP1;SPy0701)	4.2.2.1	Streptococcus pyogenes M1 GAS SF370	AAK33657.1 NP_268936.1	Q9A0M7	2C3F[A] 1.81 2PK1[A] α-L-Gulf 3.10 2YVV[A] β-D-Galp-(1-4)-α-D-Glcp 2.60 2YW0[A] 2.60 2YX2[A] 2.80
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
hyaluronate lyase (HylP1;HylP)	4.2.2.1	Streptococcus pyogenes phage H4489A	AAA98101.1	P15316	6WV2[A,B,C] 2.21 6WWX[A,B,C] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc 2.20 6WXA[A,B,C] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc 2.30 6X3M[A,B,C,D,E,F,G,H,I] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-D-1-deoxy-GlcpNAc α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-D-1-deoxy-GlcpNAc β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc 3.58
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