Polysaccharide Lyase Family 16

Activities in Familyhyaluronan lyase (EC 4.2.2.1).
Mechanism b-elimination
3D Structure Statustriple strand β-helix
NoteFormerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657. Subfamilies have been deleted in this family (December 2012).
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (435); Uniprot accession (5); PDB accession (14); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 hyaluronate lyase (HylP2) 4.2.2.1 pubmed
Streptococcus pyogenes 10403 AAA86895.1 Q54699
Q9A0M7
2DP5[A]
3EKA[A]
 hyaluronate lyase (HylP1;SPy0701) 4.2.2.1 pubmed
Streptococcus pyogenes M1 GAS AAK33657.1
NP_268936.1
Q9A0M7 2C3F[A]
2PK1[A]
2YVV[A]
2YW0[A]
2YX2[A]
 hyaluronidase (Hyal_Sk) 4.2.2.1 pubmed
Streptomyces koganeiensis ATCC 31394 AKQ62598.1 A0A0U2E2J7
A0A182DVL8
4UFQ[A,B]
Viruses
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 hyaluronate lyase (HylP1;HylP) 4.2.2.1 pubmed
Streptococcus pyogenes phage H4489A AAA98101.1 P15316 6WV2[A,B,C]
6WWX[A,B,C]
6WXA[A,B,C]
6X3M[A,B,C,D,E,F,G,H,I]
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