Polysaccharide Lyase Family 16

Activities in Familyhyaluronan lyase (EC 4.2.2.1).
3D Structure Statustriple strand β-helix
NoteFormerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657. Subfamilies have been deleted in this family (December 2012).
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (247); Uniprot accession (29); PDB accession (10); 3D entries (5); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACWT_3715   Actinoplanes sp. SE50 ATO83130.1    
 ACPL_3843   Actinoplanes sp. SE50/110 AEV84738.1
SLM00537.1
   
 KSE_55340   Kitasatospora setae KM-6054 BAJ31309.1 E4NIH9  
 SEQ_2045   Streptococcus equi subsp. equi 4047 CAW95336.1 C0M9W4  
 SE071780_02165   Streptococcus equi subsp. equi ATCC 39506 ASB97711.1    
 SE071780_00215   Streptococcus equi subsp. equi ATCC 39506 ASB95834.1    
 SE071780_01756   Streptococcus equi subsp. equi ATCC 39506 ASB97343.1    
 hyaluronate lyase (HylP2) 4.2.2.1 Streptococcus pyogenes 10403 AAA86895.1 Q54699 2DP5[A]
3EKA[A]
 SPYALAB49_001176   Streptococcus pyogenes Alab49 AEQ24773.1    
 SPYALAB49_000995   Streptococcus pyogenes Alab49 AEQ24593.1    
 SPYALAB49_001308 (fragment)   Streptococcus pyogenes Alab49 AEQ24901.1    
 SPAP1_06950   Streptococcus pyogenes AP1 AKG28345.1    
 SPAP1_05545   Streptococcus pyogenes AP1 AKG28083.1    
 SPAP1_02840   Streptococcus pyogenes AP1 AKG27558.1    
 SPAP1_03565   Streptococcus pyogenes AP1 AKG27701.1    
 AUQ45_0607 (HylP)   Streptococcus pyogenes AP53 AMY97168.1    
 AUQ45_1317 (fragment)   Streptococcus pyogenes AP53 AMY97871.1    
 AUQ45_1187 (HylP)   Streptococcus pyogenes AP53 AMY97741.1    
 AUQ45_1011 (HylP)   Streptococcus pyogenes AP53 AMY97567.1    
 DP15_245 (Hylp2)   Streptococcus pyogenes ATCC 19615 AIL10687.1    
 DP15_676 (Hylp2)   Streptococcus pyogenes ATCC 19615 AIL11612.1    
 SpyM6D471_07290   Streptococcus pyogenes D471 AKI78395.1    
 SpyM6D471_05370   Streptococcus pyogenes D471 AKI78041.1    
 SpyM6D471_06095   Streptococcus pyogenes D471 AKI78183.1    
 AL510_07135   Streptococcus pyogenes FDAARGOS_149 AMH03618.1    
 B2G65_03235   Streptococcus pyogenes GUR ASO73760.1    
 B2G65_05975   Streptococcus pyogenes GUR ASO75021.1    
 B2G65_01855   Streptococcus pyogenes GUR ASO73519.1    
 B2G65_03940   Streptococcus pyogenes GUR ASO73894.1    
 CFA72_01855   Streptococcus pyogenes GURSA1 ASO67801.1    
 CFA72_03940   Streptococcus pyogenes GURSA1 ASO68178.1    
 CFA72_03235   Streptococcus pyogenes GURSA1 ASO68044.1    
 CFA72_05975   Streptococcus pyogenes GURSA1 ASO69307.1    
 HKU360_00797   Streptococcus pyogenes HKU360 AIW24615.1    
 L897_04975   Streptococcus pyogenes HSC5 AGQ28519.1    
 L897_07515   Streptococcus pyogenes HSC5 AGQ28627.1    
 L897_05855   Streptococcus pyogenes HSC5 AGQ28574.1    
 JMUB1235_0575   Streptococcus pyogenes JMUB1235 BAV54834.1    
 SPYJRS4_1277 (HylP)   Streptococcus pyogenes JRS4 BAR44777.1
AKI76512.1
   
 SPYJRS4_1529 (Hylp2)   Streptococcus pyogenes JRS4 BAR45029.1
AKI76724.1
   
 SPYJRS4_1119 (Hylp3)   Streptococcus pyogenes JRS4 BAR44619.1
AKI76370.1
   
 CCX85_04985   Streptococcus pyogenes JS12 AUG50481.1    
 SPYKS030_09350   Streptococcus pyogenes KS030 BBB88324.1    
 SPYKS030_07700   Streptococcus pyogenes KS030 BBB88167.1    
 SPYKS030_06570   Streptococcus pyogenes KS030 BBB88055.1    
 hyaluronan lyase (HylP3)   Streptococcus pyogenes M1 GAS AAK34249.1
NP_269528.1
Q99Z19 2WB3[A]
 hyaluronate lyase (HylP2)   Streptococcus pyogenes M1 GAS AAK33900.1
NP_269179.1
Q99ZZ7 2WH7[A]
 hyaluronate lyase (HylP1;SPy0701) 4.2.2.1 Streptococcus pyogenes M1 GAS AAK33657.1
NP_268936.1
  2C3F[A]
2PK1[A]
2YVV[A]
2YW0[A]
2YX2[A]
 FE90_0215   Streptococcus pyogenes M23ND AIQ00984.1    
 FE90_0641 (HylP)   Streptococcus pyogenes M23ND AIQ01408.1    
 FE90_0460 (HylP)   Streptococcus pyogenes M23ND AIQ01229.1    
 FE90_0882 (fragment)   Streptococcus pyogenes M23ND AIQ01645.1    
 FE90_0883 (HylP) (fragment)   Streptococcus pyogenes M23ND AIQ01646.1    
 M3B_0843   Streptococcus pyogenes M3-b BAU60212.1    
 M3B_0510 (fragment)   Streptococcus pyogenes M3-b BAU59891.1    
 M3B_0511 (fragment)   Streptococcus pyogenes M3-b BAU59892.1    
 M3B_0729   Streptococcus pyogenes M3-b BAU60098.1    
 M3B_1017   Streptococcus pyogenes M3-b BAU60386.1    
 AWM58_02775   Streptococcus pyogenes MEW427 AMA68626.1    
 AWM58_05790   Streptococcus pyogenes MEW427 AMA69164.1    
 MGAS10270_Spy0590 or MGAS10270_Spy1310   Streptococcus pyogenes MGAS10270 ABF33655.1
ABF34375.1
Q1CQ53  
 M6_Spy1203   Streptococcus pyogenes MGAS10394 AAT87338.1    
 M6_Spy0993 (fragment)   Streptococcus pyogenes MGAS10394 AAT87128.1    
 M6_Spy1550   Streptococcus pyogenes MGAS10394 AAT87685.1    
 M6_Spy0059   Streptococcus pyogenes MGAS10394 AAT86194.1    
 M6_Spy1348   Streptococcus pyogenes MGAS10394 AAT87483.1    
 MGAS10750_Spy0615   Streptococcus pyogenes MGAS10750 ABF37565.1 Q1CPE4  
 MGAS10750_Spy1285   Streptococcus pyogenes MGAS10750 ABF38235.1 Q1CP68  
 MGAS11027_0588   Streptococcus pyogenes MGAS11027 ANC23593.1    
 MGAS1882_1115   Streptococcus pyogenes MGAS1882 AFC68322.1    
 MGAS27061_0575   Streptococcus pyogenes MGAS27061 ANC26858.1    
 HylP.1   Streptococcus pyogenes MGAS315 AAM79332.1
NP_664529.1
   
 HylP.2 (fragment)   Streptococcus pyogenes MGAS315 AAM79536.1
NP_664733.1
   
 HylP.3   Streptococcus pyogenes MGAS315 AAM79708.1
NP_664905.1
Q8K6W4  
 HylP.4   Streptococcus pyogenes MGAS315 AAM79821.1
NP_665018.1
   
 HylP.6   Streptococcus pyogenes MGAS315 AAM80025.1
NP_665222.1
   
 SpyM3_0928 (short fragment)   Streptococcus pyogenes MGAS315 AAM79535.1    
 HylP   Streptococcus pyogenes MGAS8232 AAL97134.1
NP_606635.1
Q8P2E9  
 HylP   Streptococcus pyogenes MGAS8232 AAL97438.1
NP_606939.1
Q8P1N7  
 HylP   Streptococcus pyogenes MGAS8232 AAL97860.1
NP_607361.1
Q8P0R1  
 HylP   Streptococcus pyogenes MGAS8232 AAL98032.1
NP_607533.1
Q8P0B1  
 HylP   Streptococcus pyogenes MGAS8232 AAL98283.1
NP_607784.1
Q8NZS7  
 MGAS9429_Spy0586   Streptococcus pyogenes MGAS9429 ABF31774.1 Q1CQV7  
 MGAS9429_Spy0843   Streptococcus pyogenes MGAS9429 ABF32031.1 Q1CQQ0  
 NCTC10085_00792   Streptococcus pyogenes NCTC10085 SQG54433.1    
 NCTC10874_01006   Streptococcus pyogenes NCTC10874 SQG15529.1    
 NCTC10876_01282   Streptococcus pyogenes NCTC10876 SQF63080.1    
 NCTC10876_01842 (Hylp3)   Streptococcus pyogenes NCTC10876 SQF63621.1    
 NCTC10876_00807   Streptococcus pyogenes NCTC10876 SQF62617.1    
 NCTC10876_01069   Streptococcus pyogenes NCTC10876 SQF62874.1    
 NCTC10877_00693   Streptococcus pyogenes NCTC10877 SQH10299.1    
 NCTC10879_01088   Streptococcus pyogenes NCTC10879 SQG28395.1    
 NCTC10879_00686   Streptococcus pyogenes NCTC10879 SQG27999.1    
 NCTC10879_01182   Streptococcus pyogenes NCTC10879 SQG28489.1    
 NCTC10879_00855   Streptococcus pyogenes NCTC10879 SQG28167.1    
 NCTC12044_01383   Streptococcus pyogenes NCTC12044 SQH27273.1    
 NCTC12045_00915   Streptococcus pyogenes NCTC12045 SQE97795.1    
 NCTC12046_01148   Streptococcus pyogenes NCTC12046 SQF19819.1    
 NCTC12046_01600   Streptococcus pyogenes NCTC12046 SQF20247.1    
 NCTC12046_01123   Streptococcus pyogenes NCTC12046 SQF19794.1    
 NCTC12047_01474 (HylP)   Streptococcus pyogenes NCTC12047 SQF21921.1    
 NCTC12050_01298 (Hylp3)   Streptococcus pyogenes NCTC12050 SQF16328.1    
 NCTC12050_01007   Streptococcus pyogenes NCTC12050 SQF16048.1    
 NCTC12052_00638   Streptococcus pyogenes NCTC12052 SQF51859.1    
 NCTC12052_01240   Streptococcus pyogenes NCTC12052 SQF52445.1    
 NCTC12052_01068 (fragment)   Streptococcus pyogenes NCTC12052 SQF52274.1    
 NCTC12052_01796 (Hylp3)   Streptococcus pyogenes NCTC12052 SQF52973.1    
 NCTC12057_01008   Streptococcus pyogenes NCTC12057 SQF10000.1    
 NCTC12059_01062   Streptococcus pyogenes NCTC12059 SQE78906.1    
 NCTC12059_00688   Streptococcus pyogenes NCTC12059 SQE78165.1    
 NCTC12062_01065   Streptococcus pyogenes NCTC12062 SQF27880.1    
 NCTC12062_00694   Streptococcus pyogenes NCTC12062 SQF27065.1    
 NCTC12064_00395   Streptococcus pyogenes NCTC12064 SQF22579.1    
 NCTC12066_00784   Streptococcus pyogenes NCTC12066 SQE93017.1    
 NCTC12067_01393   Streptococcus pyogenes NCTC12067 SQF56221.1    
 NCTC12069_01456   Streptococcus pyogenes NCTC12069 SQF04216.1    
 NCTC12069_01116   Streptococcus pyogenes NCTC12069 SQF03893.1    
 NCTC12696_01300   Streptococcus pyogenes NCTC12696 SQF12883.1    
 NCTC12696_01102   Streptococcus pyogenes NCTC12696 SQF12699.1    
 NCTC12696_01531 (HylP)   Streptococcus pyogenes NCTC12696 SQF13111.1    
 NCTC12840_00523   Streptococcus pyogenes NCTC12840 SQF36052.1    
 NCTC12840_00765   Streptococcus pyogenes NCTC12840 SQF36483.1    
 NCTC13738_00863   Streptococcus pyogenes NCTC13738 SQG19575.1    
 NCTC13739_00681   Streptococcus pyogenes NCTC13739 SQH08627.1    
 NCTC13743_01037   Streptococcus pyogenes NCTC13743 SQG22800.1    
 NCTC13744_01109   Streptococcus pyogenes NCTC13744 SQG73318.1    
 NCTC13744_01447   Streptococcus pyogenes NCTC13744 SQG73639.1    
 NCTC13745_00583   Streptococcus pyogenes NCTC13745 SQH47662.1    
 NCTC13751_01255   Streptococcus pyogenes NCTC13751 SQH62852.1    
 NCTC4001_00660 (HylP)   Streptococcus pyogenes NCTC4001 SQF50225.1    
 NCTC4001_00483 (fragment)   Streptococcus pyogenes NCTC4001 SQF50049.1    
 NCTC4001_00482 (fragment)   Streptococcus pyogenes NCTC4001 SQF50048.1    
 NCTC5163_00807   Streptococcus pyogenes NCTC5163 SQE56134.1    
 NCTC5163_01047   Streptococcus pyogenes NCTC5163 SQE56631.1    
 NCTC5163_01287   Streptococcus pyogenes NCTC5163 SQE57170.1    
 NCTC5163_01116   Streptococcus pyogenes NCTC5163 SQE56772.1    
 NCTC5164_01287   Streptococcus pyogenes NCTC5164 SQE90839.1    
 NCTC5164_01116   Streptococcus pyogenes NCTC5164 SQE90669.1    
 NCTC5164_01047   Streptococcus pyogenes NCTC5164 SQE90600.1    
 NCTC5164_00807   Streptococcus pyogenes NCTC5164 SQE90364.1    
 NCTC8195_01159   Streptococcus pyogenes NCTC8195 SQF45658.1    
 NCTC8195_00718   Streptococcus pyogenes NCTC8195 SQF44848.1    
 NCTC8195_01539   Streptococcus pyogenes NCTC8195 SQF46440.1    
 NCTC8195_00622 (Hylp3)   Streptococcus pyogenes NCTC8195 SQF44680.1    
 NCTC8195_00263   Streptococcus pyogenes NCTC8195 SQF43881.1    
 ERS445054_01453   Streptococcus pyogenes NCTC8198 CKH05333.1    
 ERS445054_00613   Streptococcus pyogenes NCTC8198 CKG82209.1    
 ERS445054_01307 (HylP)   Streptococcus pyogenes NCTC8198 CKH01474.1    
 ERS445054_00899   Streptococcus pyogenes NCTC8198 CKG90139.1    
 NCTC8224_01063 (Hylp3)   Streptococcus pyogenes NCTC8224 SRX91036.1    
 NCTC8224_00721 (Hylp_2) (fragment)   Streptococcus pyogenes NCTC8224 SRX90699.1    
 NCTC8224_00577   Streptococcus pyogenes NCTC8224 SRX90557.1    
 NCTC8224_00720 (Hylp_1) (fragment)   Streptococcus pyogenes NCTC8224 SRX90698.1    
 NCTC8225_01005   Streptococcus pyogenes NCTC8225 SQE38596.1    
 NCTC8225_00555   Streptococcus pyogenes NCTC8225 SQE38162.1    
 NCTC8225_00286   Streptococcus pyogenes NCTC8225 SQE37903.1    
 NCTC8227_00965   Streptococcus pyogenes NCTC8227 SQG52357.1    
 NCTC8227_01293   Streptococcus pyogenes NCTC8227 SQG53079.1    
 NCTC8227_01143   Streptococcus pyogenes NCTC8227 SQG52623.1    
 NCTC8230_01627   Streptococcus pyogenes NCTC8230 SQF61520.1    
 NCTC8230_01119   Streptococcus pyogenes NCTC8230 SQF60518.1    
 NCTC8230_01291 (HylP)   Streptococcus pyogenes NCTC8230 SQF60840.1    
 NCTC8230_00272   Streptococcus pyogenes NCTC8230 SQF58692.1    
 NCTC8230_00863   Streptococcus pyogenes NCTC8230 SQF60040.1    
 NCTC8231_01010   Streptococcus pyogenes NCTC8231 SQF32808.1    
 NCTC8300_01412   Streptococcus pyogenes NCTC8300 SQF02499.1    
 NCTC8300_01000   Streptococcus pyogenes NCTC8300 SQF02100.1    
 NCTC8304_01007   Streptococcus pyogenes NCTC8304 SQG96868.1    
 NCTC8314_00747 (Hylp3)   Streptococcus pyogenes NCTC8314 SQE92822.1    
 NCTC8320_00629   Streptococcus pyogenes NCTC8320 SQG42580.1    
 NCTC8320_01067 (Hylp_1)   Streptococcus pyogenes NCTC8320 SQG43352.1    
 NCTC8320_01248 (Hylp_2)   Streptococcus pyogenes NCTC8320 SQG43724.1    
 NCTC8320_01517   Streptococcus pyogenes NCTC8320 SQG44323.1    
 NCTC8322_00564   Streptococcus pyogenes NCTC8322 SRX87147.1    
 NCTC8322_01260   Streptococcus pyogenes NCTC8322 SRX87813.1    
 NCTC8324_00424   Streptococcus pyogenes NCTC8324 SQF38000.1    
 NCTC8324_01001   Streptococcus pyogenes NCTC8324 SQF38584.1    
 NCTC8324_00823   Streptococcus pyogenes NCTC8324 SQF38407.1    
 NCTC8326_00684   Streptococcus pyogenes NCTC8326 SQF57170.1    
 NCTC8326_01331   Streptococcus pyogenes NCTC8326 SQF57802.1    
 NCTC8328_00784   Streptococcus pyogenes NCTC8328 SQF09662.1    
 NCTC8328_00395   Streptococcus pyogenes NCTC8328 SQF08894.1    
 NCTC8332_01047   Streptococcus pyogenes NCTC8332 SQF17824.1    
 NCTC8332_01287   Streptococcus pyogenes NCTC8332 SQF18063.1    
 NCTC8332_01116   Streptococcus pyogenes NCTC8332 SQF17893.1    
 NCTC8332_00807   Streptococcus pyogenes NCTC8332 SQF17588.1    
 SD89_06270   Streptococcus pyogenes NGAS322 AKZ50707.1    
 SD89_06945   Streptococcus pyogenes NGAS322 AKZ50836.1    
 SD89_05005   Streptococcus pyogenes NGAS322 AKZ50471.1    
 DK93_03885   Streptococcus pyogenes NGAS327 AKI38591.1    
 DK92_05065   Streptococcus pyogenes NGAS596 AKI37192.1    
 SD90_04815   Streptococcus pyogenes NGAS638 AKZ52250.1    
 DI45_04145   Streptococcus pyogenes NGAS743 AKI35205.1    
 DI45_03205   Streptococcus pyogenes NGAS743 AKI35031.1    
 C5P47_05700   Streptococcus pyogenes NGAS979 AWS23441.1    
 Spy49_0785   Streptococcus pyogenes NZ131 ACI61098.1 B5XL86  
 Spy49_1465c   Streptococcus pyogenes NZ131 ACI61737.1 B5XI75  
 SPs0763   Streptococcus pyogenes SSI-1 BAC63858.1
NP_802025.1
Q878Y7  
 SPs0927   Streptococcus pyogenes SSI-1 BAC64022.1
NP_802189.1
Q878T2  
 SPs0447   Streptococcus pyogenes SSI-1 BAC63542.1
NP_801709.1
F7ITM1  
 SPs1127 (fragment)   Streptococcus pyogenes SSI-1 BAC64222.1
NP_802389.1
Q878N5  
 SPs0648   Streptococcus pyogenes SSI-1 BAC63743.1
NP_801910.1
Q79XT2  
 B4W66_05875   Streptococcus pyogenes STAB090229 ASQ21424.1    
 B5D85_06210   Streptococcus pyogenes STAB120304 ASQ23235.1    
 AXK13_03295   Streptococcus pyogenes STAB13021 AND04600.1    
 AXK13_07410   Streptococcus pyogenes STAB13021 AND05369.1    
 AYM92_06065   Streptococcus pyogenes STAB14018 ARV01471.1    
 STAB902_02535   Streptococcus pyogenes STAB902 AIG46749.1
AIG47403.1
   
 STAB902_04220   Streptococcus pyogenes STAB902 AIG47045.1    
 STAB902_03630   Streptococcus pyogenes STAB902 AIG46933.1
AIG47203.1
   
 SpyM50524   Streptococcus pyogenes str. Manfredo CAM29863.1 A2RDD8  
 SpyM50680   Streptococcus pyogenes str. Manfredo CAM30013.1 A2RDT8  
 SpyM51031   Streptococcus pyogenes str. Manfredo CAM30356.1 A2RET0  
 SpyM51271   Streptococcus pyogenes str. Manfredo CAM30596.1 A2RDD8  
 hyaluronidase (Hyal_Sk) 4.2.2.1 Streptomyces koganeiensis ATCC 31394 AKQ62598.1   4UFQ[A,B]
 SPRI_5080   Streptomyces pristinaespiralis HCCB 10218 ALC23386.1    
 A4G23_04569   Streptomyces rubrolavendulae MJM4426 AOT61680.1    
 SVEN_4145   Streptomyces venezuelae ATCC 10712 CCA57431.1    
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 hylauronidase   Streptococcus phage P9 ABL61072.1 A7J2A8  
 hyaluronate lyase (HylP1;HylP) 4.2.2.1 Streptococcus pyogenes phage H4489A AAA98101.1 P15316  
 hyaluronidase   Temperate phage phiNIH1.1 AAL15086.1
NP_438157.1
Q938K0  
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