Polysaccharide Lyase Family 16

Activities in Familyhyaluronan lyase (EC 4.2.2.1).
3D Structure Statustriple strand β-helix
NoteFormerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657. Subfamilies have been deleted in this family (December 2012).
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (143); Uniprot accession (29); PDB accession (10); 3D entries (5); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACPL_3843 (probable fragment)   Actinoplanes sp. SE50/110 AEV84738.1
SLM00537.1
   
 KSE_55340 (probable fragment)   Kitasatospora setae KM-6054 BAJ31309.1 E4NIH9  
 SEQ_2045   Streptococcus equi subsp. equi 4047 CAW95336.1 C0M9W4  
 SE071780_02165   Streptococcus equi subsp. equi ATCC 39506 ASB97711.1    
 SE071780_00215   Streptococcus equi subsp. equi ATCC 39506 ASB95834.1    
 SE071780_01756   Streptococcus equi subsp. equi ATCC 39506 ASB97343.1    
 hyaluronate lyase (HylP2) 4.2.2.1 Streptococcus pyogenes 10403 AAA86895.1 Q54699 2DP5[A]
3EKA[A]
 SPYALAB49_001176   Streptococcus pyogenes Alab49 AEQ24773.1    
 SPYALAB49_000995   Streptococcus pyogenes Alab49 AEQ24593.1    
 SPYALAB49_001308 (fragment)   Streptococcus pyogenes Alab49 AEQ24901.1    
 SPAP1_06950   Streptococcus pyogenes AP1 AKG28345.1    
 SPAP1_05545   Streptococcus pyogenes AP1 AKG28083.1    
 SPAP1_02840   Streptococcus pyogenes AP1 AKG27558.1    
 SPAP1_03565   Streptococcus pyogenes AP1 AKG27701.1    
 AUQ45_0607 (HylP)   Streptococcus pyogenes AP53 AMY97168.1    
 AUQ45_1317 (fragment)   Streptococcus pyogenes AP53 AMY97871.1    
 AUQ45_1187 (HylP)   Streptococcus pyogenes AP53 AMY97741.1    
 AUQ45_1011 (HylP)   Streptococcus pyogenes AP53 AMY97567.1    
 DP15_245 (Hylp2)   Streptococcus pyogenes ATCC 19615 AIL10687.1    
 DP15_676 (Hylp2)   Streptococcus pyogenes ATCC 19615 AIL11612.1    
 SpyM6D471_07290   Streptococcus pyogenes D471 AKI78395.1    
 SpyM6D471_05370   Streptococcus pyogenes D471 AKI78041.1    
 SpyM6D471_06095   Streptococcus pyogenes D471 AKI78183.1    
 AL510_07135   Streptococcus pyogenes FDAARGOS_149 AMH03618.1    
 B2G65_03235   Streptococcus pyogenes GUR ASO73760.1    
 B2G65_05975   Streptococcus pyogenes GUR ASO75021.1    
 B2G65_01855   Streptococcus pyogenes GUR ASO73519.1    
 B2G65_03940   Streptococcus pyogenes GUR ASO73894.1    
 CFA72_01855   Streptococcus pyogenes GURSA1 ASO67801.1    
 CFA72_03940   Streptococcus pyogenes GURSA1 ASO68178.1    
 CFA72_03235   Streptococcus pyogenes GURSA1 ASO68044.1    
 CFA72_05975   Streptococcus pyogenes GURSA1 ASO69307.1    
 HKU360_00797   Streptococcus pyogenes HKU360 AIW24615.1    
 L897_04975   Streptococcus pyogenes HSC5 AGQ28519.1    
 L897_07515   Streptococcus pyogenes HSC5 AGQ28627.1    
 L897_05855   Streptococcus pyogenes HSC5 AGQ28574.1    
 JMUB1235_0575   Streptococcus pyogenes JMUB1235 BAV54834.1    
 SPYJRS4_1277 (HylP)   Streptococcus pyogenes JRS4 BAR44777.1
AKI76512.1
   
 SPYJRS4_1529 (Hylp2)   Streptococcus pyogenes JRS4 BAR45029.1
AKI76724.1
   
 SPYJRS4_1119 (Hylp3)   Streptococcus pyogenes JRS4 BAR44619.1
AKI76370.1
   
 hyaluronan lyase (HylP3)   Streptococcus pyogenes M1 GAS AAK34249.1
NP_269528.1
Q99Z19 2WB3[A]
 hyaluronate lyase (HylP2)   Streptococcus pyogenes M1 GAS AAK33900.1
NP_269179.1
Q99ZZ7 2WH7[A]
 hyaluronate lyase (HylP1;SPy0701) 4.2.2.1 Streptococcus pyogenes M1 GAS AAK33657.1
NP_268936.1
  2C3F[A]
2PK1[A]
2YVV[A]
2YW0[A]
2YX2[A]
 FE90_0215   Streptococcus pyogenes M23ND AIQ00984.1    
 FE90_0641 (HylP)   Streptococcus pyogenes M23ND AIQ01408.1    
 FE90_0460 (HylP)   Streptococcus pyogenes M23ND AIQ01229.1    
 FE90_0882 (fragment)   Streptococcus pyogenes M23ND AIQ01645.1    
 FE90_0883 (HylP) (fragment)   Streptococcus pyogenes M23ND AIQ01646.1    
 M3B_0843   Streptococcus pyogenes M3-b BAU60212.1    
 M3B_0510 (fragment)   Streptococcus pyogenes M3-b BAU59891.1    
 M3B_0511 (fragment)   Streptococcus pyogenes M3-b BAU59892.1    
 M3B_0729   Streptococcus pyogenes M3-b BAU60098.1    
 M3B_1017   Streptococcus pyogenes M3-b BAU60386.1    
 AWM58_02775   Streptococcus pyogenes MEW427 AMA68626.1    
 AWM58_05790   Streptococcus pyogenes MEW427 AMA69164.1    
 MGAS10270_Spy0590 or MGAS10270_Spy1310   Streptococcus pyogenes MGAS10270 ABF33655.1
ABF34375.1
Q1CQ53  
 M6_Spy1203   Streptococcus pyogenes MGAS10394 AAT87338.1    
 M6_Spy0993 (fragment)   Streptococcus pyogenes MGAS10394 AAT87128.1    
 M6_Spy1550   Streptococcus pyogenes MGAS10394 AAT87685.1    
 M6_Spy0059   Streptococcus pyogenes MGAS10394 AAT86194.1    
 M6_Spy1348   Streptococcus pyogenes MGAS10394 AAT87483.1    
 MGAS10750_Spy0615   Streptococcus pyogenes MGAS10750 ABF37565.1 Q1CPE4  
 MGAS10750_Spy1285   Streptococcus pyogenes MGAS10750 ABF38235.1 Q1CP68  
 MGAS11027_0588   Streptococcus pyogenes MGAS11027 ANC23593.1    
 MGAS1882_1115   Streptococcus pyogenes MGAS1882 AFC68322.1    
 MGAS27061_0575   Streptococcus pyogenes MGAS27061 ANC26858.1    
 HylP.1   Streptococcus pyogenes MGAS315 AAM79332.1
NP_664529.1
   
 HylP.2 (fragment)   Streptococcus pyogenes MGAS315 AAM79536.1
NP_664733.1
   
 HylP.3   Streptococcus pyogenes MGAS315 AAM79708.1
NP_664905.1
Q8K6W4  
 HylP.4   Streptococcus pyogenes MGAS315 AAM79821.1
NP_665018.1
   
 HylP.6   Streptococcus pyogenes MGAS315 AAM80025.1
NP_665222.1
   
 SpyM3_0928 (short fragment)   Streptococcus pyogenes MGAS315 AAM79535.1    
 HylP   Streptococcus pyogenes MGAS8232 AAL97134.1
NP_606635.1
Q8P2E9  
 HylP   Streptococcus pyogenes MGAS8232 AAL97438.1
NP_606939.1
Q8P1N7  
 HylP   Streptococcus pyogenes MGAS8232 AAL97860.1
NP_607361.1
Q8P0R1  
 HylP   Streptococcus pyogenes MGAS8232 AAL98032.1
NP_607533.1
Q8P0B1  
 HylP   Streptococcus pyogenes MGAS8232 AAL98283.1
NP_607784.1
Q8NZS7  
 MGAS9429_Spy0586   Streptococcus pyogenes MGAS9429 ABF31774.1 Q1CQV7  
 MGAS9429_Spy0843   Streptococcus pyogenes MGAS9429 ABF32031.1 Q1CQQ0  
 ERS445054_01453   Streptococcus pyogenes NCTC8198 CKH05333.1    
 ERS445054_00613   Streptococcus pyogenes NCTC8198 CKG82209.1    
 ERS445054_01307 (HylP)   Streptococcus pyogenes NCTC8198 CKH01474.1    
 ERS445054_00899   Streptococcus pyogenes NCTC8198 CKG90139.1    
 SD89_06270   Streptococcus pyogenes NGAS322 AKZ50707.1    
 SD89_06945   Streptococcus pyogenes NGAS322 AKZ50836.1    
 SD89_05005   Streptococcus pyogenes NGAS322 AKZ50471.1    
 DK93_03885   Streptococcus pyogenes NGAS327 AKI38591.1    
 DK92_05065   Streptococcus pyogenes NGAS596 AKI37192.1    
 SD90_04815   Streptococcus pyogenes NGAS638 AKZ52250.1    
 DI45_04145   Streptococcus pyogenes NGAS743 AKI35205.1    
 DI45_03205   Streptococcus pyogenes NGAS743 AKI35031.1    
 Spy49_0785   Streptococcus pyogenes NZ131 ACI61098.1 B5XL86  
 Spy49_1465c   Streptococcus pyogenes NZ131 ACI61737.1 B5XI75  
 SPs0763   Streptococcus pyogenes SSI-1 BAC63858.1
NP_802025.1
Q878Y7  
 SPs0927   Streptococcus pyogenes SSI-1 BAC64022.1
NP_802189.1
Q878T2  
 SPs0447   Streptococcus pyogenes SSI-1 BAC63542.1
NP_801709.1
F7ITM1  
 SPs1127 (fragment)   Streptococcus pyogenes SSI-1 BAC64222.1
NP_802389.1
Q878N5  
 SPs0648   Streptococcus pyogenes SSI-1 BAC63743.1
NP_801910.1
Q79XT2  
 B4W66_05875   Streptococcus pyogenes STAB090229 ASQ21424.1    
 B5D85_06210   Streptococcus pyogenes STAB120304 ASQ23235.1    
 AXK13_03295   Streptococcus pyogenes STAB13021 AND04600.1    
 AXK13_07410   Streptococcus pyogenes STAB13021 AND05369.1    
 AYM92_06065   Streptococcus pyogenes STAB14018 ARV01471.1    
 STAB902_02535   Streptococcus pyogenes STAB902 AIG46749.1
AIG47403.1
   
 STAB902_04220   Streptococcus pyogenes STAB902 AIG47045.1    
 STAB902_03630   Streptococcus pyogenes STAB902 AIG46933.1
AIG47203.1
   
 SpyM50524   Streptococcus pyogenes str. Manfredo CAM29863.1 A2RDD8  
 SpyM50680   Streptococcus pyogenes str. Manfredo CAM30013.1 A2RDT8  
 SpyM51031   Streptococcus pyogenes str. Manfredo CAM30356.1 A2RET0  
 SpyM51271   Streptococcus pyogenes str. Manfredo CAM30596.1 A2RDD8  
 hyaluronidase (Hyal_Sk) (probable fragment) 4.2.2.1 Streptomyces koganeiensis ATCC 31394 AKQ62598.1   4UFQ[A,B]
 SPRI_5080 (probable fragment)   Streptomyces pristinaespiralis HCCB 10218 ALC23386.1    
 A4G23_04569   Streptomyces rubrolavendulae MJM4426 AOT61680.1    
 SVEN_4145 (fragment)   Streptomyces venezuelae ATCC 10712 CCA57431.1    
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 hylauronidase   Streptococcus phage P9 ABL61072.1 A7J2A8  
 hyaluronate lyase (HylP1;HylP) 4.2.2.1 Streptococcus pyogenes phage H4489A AAA98101.1 P15316  
 hyaluronidase   Temperate phage phiNIH1.1 AAL15086.1
NP_438157.1
Q938K0  
Top


Last update: 2017-10-09 © Copyright 1998-2017
AFMB - CNRS - Université d'Aix-Marseille