Activities in Family	Heparin lyase / heparin lyase I (EC 4.2.2.7); Heparin-sulfate lyase / heparin lyase III (EC 4.2.2.8);
Mechanism	b-elimination
3D Structure Status	( α / α ) 5 toroid + anti-parallel β-sheet
Statistics	GenBank accession (2091); Uniprot accession (5); PDB accession (5); 3D entries (3); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
EHF40_02825		Streptococcus pyogenes Duke-Large	AZA34921.1			1
ETT58_02865		Streptococcus pyogenes emm1	QCK50440.1			1
ETT46_03075		Streptococcus pyogenes emm100	QCK70584.1			1
ETT68_02960		Streptococcus pyogenes emm105	QCK33562.1			1
ETT67_02710		Streptococcus pyogenes emm11	QCK35159.1			1
ETT47_02720		Streptococcus pyogenes emm123	QCK68923.1			1
ETT59_06350		Streptococcus pyogenes emm124	QCK49424.1			1
ETT44_06775		Streptococcus pyogenes emm197	QCK74638.1			1
ETT61_06450		Streptococcus pyogenes emm22.8	QCK45919.1			1
ETT48_02720		Streptococcus pyogenes emm230	QCK67205.1			1
ETT57_02700		Streptococcus pyogenes emm25	QCK52156.1			1
ETT45_02705		Streptococcus pyogenes emm54	QCK72256.1			1
ETT69_02935		Streptococcus pyogenes emm55	QCK31785.1			1
ETT50_06905		Streptococcus pyogenes emm56	QCK64675.1			1
ETT73_02840		Streptococcus pyogenes emm57	QCK24992.1			1
ETT56_07010		Streptococcus pyogenes emm58	QCK54671.1			1
ETT64_06600		Streptococcus pyogenes emm64.3	QCK40947.1			1
ETT66_06655		Streptococcus pyogenes emm65	QCK37537.1			1
ETT53_06255		Streptococcus pyogenes emm68.2	QCK59545.1			1
ETT51_02980		Streptococcus pyogenes emm70	QCK62230.1			1
ETT72_03075		Streptococcus pyogenes emm74	QCK26665.1			1
ETT65_06925		Streptococcus pyogenes emm75.1	QCK39248.1			1
ETT60_02825		Streptococcus pyogenes emm77	QCK47108.1			1
ETT62_06175		Streptococcus pyogenes emm78.3	QCK44225.1			1
ETT63_06565		Streptococcus pyogenes emm89.14	QCK42620.1			1
ETT55_02890		Streptococcus pyogenes emm90.5	QCK55693.1			1
ETT49_02695		Streptococcus pyogenes emm93.4	QCK65635.1			1
ETT52_02660		Streptococcus pyogenes emm97.1	QCK60496.1			1
JAN99_06575		Streptococcus pyogenes emm9ST603	QQA63792.1			1
ETT70_02785		Streptococcus pyogenes emmNA	QCK30054.1			1
ETT71_03060		Streptococcus pyogenes emmSTG866.1	QCK28438.1			1
AL510_01090		Streptococcus pyogenes FDAARGOS_149	AMH02543.1			1
EGX80_07585		Streptococcus pyogenes FDAARGOS_514	AYZ09926.1			1
EGX78_02830		Streptococcus pyogenes FDAARGOS_534	AYZ02448.1			1
FOB76_01650		Streptococcus pyogenes FDAARGOS_668	QEU36026.1			1
FIU13_08205		Streptococcus pyogenes FDAARGOS_774	QDC77927.1			1
B2G65_07275		Streptococcus pyogenes GUR	ASO74520.1			1
CFA72_07275		Streptococcus pyogenes GURSA1	ASO68805.1			1
SPYH293_00542		Streptococcus pyogenes H293	CDJ54798.1			1
CRD75_02680		Streptococcus pyogenes HarveyGAS	ATL56503.1			1
HKU360_00529		Streptococcus pyogenes HKU360	AIW24357.1			1
HKU488_00433 (HepC)		Streptococcus pyogenes HKU488	AKP81368.1			1
L897_02790		Streptococcus pyogenes HSC5	AGQ27350.1			1
JMUB1235_0528		Streptococcus pyogenes JMUB1235	BAV54787.1			1
SPYJRS4_0520		Streptococcus pyogenes JRS4	BAR44020.1 AKI75841.1			1
CCX85_02715		Streptococcus pyogenes JS12	AUG50050.1			1
SPYKS030_14340		Streptococcus pyogenes KS030	BBB88812.1			1
M1GAS476_0572		Streptococcus pyogenes M1 476	BAM29906.1 BAM29906.2			1
SPy0628		Streptococcus pyogenes M1 GAS SF370	AAK33596.1 NP_268875.1			1
FE90_0138		Streptococcus pyogenes M23ND	AIQ00907.1			1
ABO05_06830		Streptococcus pyogenes M28PF1	AKJ92983.1			1
M3B_1521		Streptococcus pyogenes M3-b	BAU60886.1			1
EGC57_02710		Streptococcus pyogenes M75	QAZ36621.1			1
AWM59_06700		Streptococcus pyogenes MEW123	AMA70902.1			1
AWM58_02635		Streptococcus pyogenes MEW427	AMA68604.1			1
MGAS10270_Spy0513 + MGAS10270_Spy0512 (fragments)		Streptococcus pyogenes MGAS10270	ABF33577.1 ABF33578.1
M6_Spy0539		Streptococcus pyogenes MGAS10394	AAT86674.1			1
MGAS10750_Spy0537		Streptococcus pyogenes MGAS10750	ABF37487.1			1
DZN22_07260		Streptococcus pyogenes MGAS10786	QBB28033.1			1
DZN59_06700		Streptococcus pyogenes MGAS10826	QBB29880.1			1
MGAS11027_0530		Streptococcus pyogenes MGAS11027	ANC23535.1			1
DZN63_06950		Streptococcus pyogenes MGAS11052	QBB31652.1			1
DZN89_06700		Streptococcus pyogenes MGAS11108	QBB33383.1			1
DZN94_06720		Streptococcus pyogenes MGAS11115	QBB35114.1			1
MGAS15252_0544		Streptococcus pyogenes MGAS15252	AFC65895.1			1
MGAS1882_0541		Streptococcus pyogenes MGAS1882	AFC67764.1			1
MGAS2096_Spy0530		Streptococcus pyogenes MGAS2096	ABF35582.1			1
MGAS2221_0554		Streptococcus pyogenes MGAS2221	QJC39274.1			1
MGAS23530_0525		Streptococcus pyogenes MGAS23530	ANC25214.1			1
MGAS27061_0533		Streptococcus pyogenes MGAS27061	ANC26816.1			1
MGAS27961_06700		Streptococcus pyogenes MGAS27961	AZZ62910.1			1
DZQ17_06955		Streptococcus pyogenes MGAS28078	QBB36896.1			1
MGAS28085_06695		Streptococcus pyogenes MGAS28085	AZZ64643.1			1
DZR09_06940		Streptococcus pyogenes MGAS28191	QBB38648.1			1
DZR83_06635		Streptococcus pyogenes MGAS28271	QBB40371.1			1
DZR90_02915		Streptococcus pyogenes MGAS28278	QBB41412.1			1
DZS39_06665		Streptococcus pyogenes MGAS28330	QBB43872.1			1
DZS66_06705		Streptococcus pyogenes MGAS28360	QBB45594.1			1
DZS91_06695		Streptococcus pyogenes MGAS28386	QBB47367.1			1
DZU27_07030		Streptococcus pyogenes MGAS28533	QBB49129.1			1
DZV37_06705		Streptococcus pyogenes MGAS28650	QBB50858.1			1
DZV55_07070		Streptococcus pyogenes MGAS28669	QBB52654.1			1
DZV70_07035		Streptococcus pyogenes MGAS28686	QBB54454.1			1
DZW30_06710		Streptococcus pyogenes MGAS28746	QBB56174.1			1
DZY54_06700		Streptococcus pyogenes MGAS29064	QBB57904.1			1
DZ066_07310		Streptococcus pyogenes MGAS29284	QBB59731.1			1
DZ106_06955		Streptococcus pyogenes MGAS29326	QBB61515.1			1
DZ187_06980		Streptococcus pyogenes MGAS29409	QBB63346.1			1
SpyM3_0442		Streptococcus pyogenes MGAS315	AAM79049.1 NP_664246.1			1
M5005_Spy_0518		Streptococcus pyogenes MGAS5005	AAZ51136.1			1
M28_Spy0497		Streptococcus pyogenes MGAS6180	AAX71611.1 AAX71611.2			1
DZL14_02670		Streptococcus pyogenes MGAS7888	QBB21884.1			1
DZL40_06700		Streptococcus pyogenes MGAS7914	QBB24457.1			1
SpyM18_0693		Streptococcus pyogenes MGAS8232	AAL97364.1 NP_606865.1			1
DZM45_06610		Streptococcus pyogenes MGAS8347	QBB26220.1			1
MGAS9429_Spy0509		Streptococcus pyogenes MGAS9429	ABF31697.1			1
MTB313_0562		Streptococcus pyogenes MTB313	BAQ50974.1			1
MTB314_0531		Streptococcus pyogenes MTB314	BAQ52701.1			1
NCTC10085_00528		Streptococcus pyogenes NCTC10085	SQG54179.1			1
NCTC10874_00558		Streptococcus pyogenes NCTC10874	SQG15101.1			1
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