Polysaccharide Lyase Family 12

Activities in Familyheparin-sulfate lyase (EC 4.2.2.8); heparin lyase / heparin lyase I (EC 4.2.2.7)
Mechanism b-elimination
3D Structure Status( a / a ) 5 toroid + anti-parallel β-sheet
Statistics GenBank accession (1495); Uniprot accession (80); PDB accession (5); 3D entries (3); cryst (0)
All (1459) Archaea (1) Bacteria (1458) Structure (3) Characterized (4)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 lyase cleaving heparin, heparan sulfate and desulfated heparin (HepIII; BT4662) 4.2.2.7
4.2.2.8
Bacteroides thetaiotaomicron VPI-5482 AAO79767.1
NP_813573.1
Q89YR9
4FNV[A] 1.80
2
 lyase cleaving heparin, heparan sulfate and desulfated heparin (Hep III; BT4657;BT_4657) 4.2.2.7
4.2.2.8
Bacteroides thetaiotaomicron VPI-5482 AAO79762.1
NP_813568.1
Q89YS4
5JMD[A] 1.80
5JMF[A] 1.80
2
 heparin-sulfate lyase / heparinase III (HepC;Phep_3797) 4.2.2.8 Pedobacter heparinus DSM 2366 ACU05988.1
AAB18278.1
ACH00306.1
ACK26501.1
C6XUY0
Q59289
4MMH[A] 2.05
4MMI[A] 2.75
2
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