GlycosylTransferase Family 66

Known Activities	Dol-PP-α-oligosaccharide: protein β-oligosaccharyltransferase (EC 2.4.1.119)
Mechanism	Inverting
3D Structure Status	GT-C
Note	These enzymes utilise an oligosaccharide-PP-dolichol as the donor
External resources	InterPro; PFAM;
Statistics	GenBank accession (504); Uniprot accession (241); PDB accession (4); 3D entries (3); cryst (0)

Summary

All (381) Archaea (177) Bacteria (43) Eukaryota (160) unclassified (1) Structure (3 ) Characterized (15)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
oligosaccharyltransferase (AglB;Stt3)	2.4.1.119	Haloferax volcanii WR536 (H53)	CAP58184.1	A9JPF0
oligosaccharyltransferase (AglB;Stt3;Mv1749;MVO1749)	2.4.1.119	Methanococcus voltae PS	ABD17750.1
oligosaccharyltransferase (AglB;Stt3;PF0156)	2.4.1.119	Pyrococcus furiosus DSM 3638	AAL80280.1 NP_577885.1	Q8U4D2	2ZAG[A,B,C,D] 2ZAI[A,B,C,D]
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
oligosaccharyltransferase (PglB;WlaF)	2.4.1.119	Campylobacter jejuni subsp. jejuni 81-176	AAD51383.1 AAK97438.1	A1W0B2 Q93DP5 Q9S4V7
oligosaccharyltransferase (PglB;WlaF;Cj1126c)	2.4.1.119	Campylobacter jejuni subsp. jejuni NCTC 11168	AAD09293.1 CAB73381.1 CAL35243.1 NP_282274.1	Q9ZAC7
oligosaccharyltransferase (PglB;Cla_1253)	2.4.1.119	Campylobacter lari RM2100 RM2100; ATCC BAA-1060D	ACM64573.1	B9KDD4	3RCE[A]
oligosaccharyltransferase (PglB1)	2.4.1.119	Helicobacter pullorum NCTC 12824	ADM36003.1	E1B265
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
oligosaccharyltransferase subunit STT3 (Stt3A;B5;ITM1)	2.4.1.119	Homo sapiens	AAB05994.1 AAH20965.1 AAH48348.1 AAH48348.2 AAL77539.1 AAP35764.1 ACM84938.1 BAF82729.1 BAG58686.1 CAH05569.1 CAH05570.1 CAH05571.1 CAH05572.1 NP_689926.1	P46977 Q86XU9 Q8TE35
oligosaccharyltransferase STT3 subunit (YGL022w;Stt3;RHK2)	2.4.1.119	Saccharomyces cerevisiae S288c	ABC17138.1 BAA06079.1 CAA96722.1 NP_011493.1	P39007
oligosaccharyltransferase (Stt3;SPBC1271.02)	2.4.1.119	Schizosaccharomyces pombe 972h-	BAA76479.1 CAA22192.1 NP_595148.1	O94335 O94335.1
oligosaccharyltransferase (Stt3)	2.4.1.119	Toxoplasma gondii RH TACHYZOITES	CAB38944.1	O97353
oligosaccharyltransferase (Stt3C;Tb927.5.910)	2.4.1.119	Trypanosoma brucei	AAX70183.1 AAX70186.1	Q57W36
oligosaccharyltransferase (Stt3B;Tb927.5.900)	2.4.1.119	Trypanosoma brucei	AAX70184.1	Q57W35
oligosaccharyltransferase (Stt3A;Tb927.5.890)	2.4.1.119	Trypanosoma brucei	AAX70185.1	Q57W34
oligosaccharyltransferase (Stt3;Tc00.1047053505163.80)	2.4.1.119	Trypanosoma cruzi CL BRENER	EAN86688.1	Q4D2C9

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.