GlycosylTransferase Family 66

Activities in Familydolichyl-diphosphooligosaccharide—protein glycotransferase (EC 2.4.99.18); undecaprenyl-diphosphooligosaccharide—protein glycotransferase (EC 2.4.99.19)
Mechanism Inverting
3D Structure StatusGT-C
NoteThese enzymes utilize a lipid-diphospho-oligosaccharide as the donor
External resourcesGlymap;
Statistics GenBank accession (1740); Uniprot accession (268); PDB accession (19); 3D entries (11); cryst (0)
All (1588) Archaea (634) Bacteria (389) Eukaryota (562) unclassified (3) Structure (11) Characterized (17)
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 oligosaccharyltransferase (AglB-S1;AfAglB-S1;AF0329;AF_0329) 2.4.99.18 Archaeoglobus fulgidus DSM 4304 AAB90907.1
NP_069165.1
O29918
3VGP[A] 1.75
 oligosaccharyltransferase (AglB-S2;AfAglB-S2;AF0040;AF_0040)   Archaeoglobus fulgidus DSM 4304 AAB91198.1
NP_068881.1
O30195
3VU0[A,B,C] 1.94
 oligosaccharyltransferase (AglB-L;AfAglB-L;AF_0380) 2.4.99.18 Archaeoglobus fulgidus DSM 4304 AAB90856.1 O29867
3WAI[A] 1.90
3WAJ[A] 2.50
3WAK[A] 3.41
5GMY[A] 3.50
 oligosaccharyltransferase (AglB-L;PAB2202)   Pyrococcus abyssi GE5 CAB49148.1
NP_125917.1
Q9V250
3WOV[A] 3.11
 oligosaccharyltransferase (AglB;Stt3;PF0156) 2.4.99.18 Pyrococcus furiosus DSM 3638 AAL80280.1
NP_577885.1
Q8U4D2
2ZAG[A,B,C,D] 3.00
2ZAI[A,B,C,D] 2.70
5AZA[A] α-D-Glcp-(1-4)-α-D-Glcp
2.08
 oligosaccharyltransferase (AglB-L;PhAglB-L;PH0242)   Pyrococcus horikoshii OT3 BAA29314.1
NP_142238.1
O74088
3VU1[A,B] 2.70
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 CJE1268 ((PglB)   Campylobacter jejuni RM1221 AAW35590.1 Q5HTX9
3AAG[A,B] 2.80
 Undecaprenyl-diphosphooligosaccharide--protein glycotransferase (PglB;Cla_1253) 2.4.99.19 Campylobacter lari RM2100 ACM64573.1 B9KDD4
3RCE[A] 3.40
5OGL[A] 2.70
6GXC[A] 3.40
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 oligosaccharyltransferase subunit STT3 (Stt3A;B5;ITM1) 2.4.99.18 Homo sapiens NP_689926.1
AAB05994.1
AAH20965.1
AAH48348.1
AAH48348.2
AAL77539.1
AAP35764.1
ACM84938.1
BAF82729.1
BAG58686.1
CAH05569.1
CAH05570.1
CAH05571.1
CAH05572.1
P46977
Q86XU9
Q8TE35
6S7O[A] β-L-Glcp-(1-1)-<non_carb>
3.50
 OST-B (SIMP)   Homo sapiens AAL71884.1
AAH15880.1
ABA83583.1
ABA84110.1
BAB55370.1
BAC11076.1
BAC11581.1
CAC39710.1
CAE48447.1
CAE91783.1
CAF00240.1
CAF85831.1
CAI72081.1
NP_849193.1
Q8N2N0
Q8TCJ2
Q96KY7
6S7T[A] 3.50
 oligosaccharyltransferase STT3 subunit (YGL022w;Stt3;RHK2) 2.4.99.18 Saccharomyces cerevisiae S288c BAA06079.1
ABC17138.1
CAA96722.1
NP_011493.1
P39007
6C26[A] 3.50
6EZN[F] 3.30
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