Activities in Family	Dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase (EC 2.4.1.119); Dolichyl-diphosphooligosaccharide—protein glycotransferase (EC 2.4.99.18); Undecaprenyl-diphosphooligosaccharide--protein glycotransferase (EC 2.4.99.19);
Mechanism	Inverting
3D Structure Status	GT-C
Note	These enzymes utilize a lipid-diphospho-oligosaccharide as the donor
External resources	Glymap;
Statistics	GenBank accession (2627); Uniprot accession (28); PDB accession (47); 3D entries (12); cryst (0)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
oligosaccharyltransferase (AglB-S1;AfAglB-S1;AF0329;AF_0329)	2.4.99.18	Archaeoglobus fulgidus DSM 4304	AAB90907.1 NP_069165.1	O29918	3VGP[A] 1.75
oligosaccharyltransferase (AglB-S2;AfAglB-S2;AF0040;AF_0040)		Archaeoglobus fulgidus DSM 4304	AAB91198.1 NP_068881.1		3VU0[A,B,C] 1.94
oligosaccharyltransferase (AglB-L;AfAglB-L;AF_0380)	2.4.99.18	Archaeoglobus fulgidus DSM 4304	AAB90856.1	O29867	3WAI[A] 1.90 3WAJ[A] 2.50 3WAK[A] 3.41 5GMY[A] 3.50 7E9S[A] 2.70
oligosaccharyltransferase (AglB-L;PAB2202)		Pyrococcus abyssi GE5	CAB49148.1 NP_125917.1		3WOV[A] 3.11
oligosaccharyltransferase (AglB;Stt3;PF0156)	2.4.99.18	Pyrococcus furiosus DSM 3638	AAL80280.1 NP_577885.1	I6V0B8 Q8U4D2	2ZAG[A,B,C,D] 3.00 2ZAI[A,B,C,D] 2.70 5AZA[A] α-D-Glcp-(1-4)-α-D-Glcp 2.08
oligosaccharyltransferase (AglB-L;PhAglB-L;PH0242)	2.4.1.119	Pyrococcus horikoshii OT3	BAA29314.1 NP_142238.1	O74088	3VU1[A,B] 2.70
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
CJE1268 (PglB)		Campylobacter jejuni RM1221	AAW35590.1		3AAG[A,B] 2.80
Undecaprenyl-diphosphooligosaccharide--protein glycotransferase (PglB;Cla_1253)	2.4.99.19	Campylobacter lari RM2100	ACM64573.1	B9KDD4	3RCE[A] 3.40 5OGL[A] 2.70 6GXC[A] 3.40
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
dolichyl-diphosphooligosaccharide: protein glycotransferase / oligosaccharyltransferase subunit STT3 (OST-A; Stt3A; B5; ITM1)	2.4.99.18	Homo sapiens	NP_689926.1 AAB05994.1 AAH20965.1 AAH48348.1 AAH48348.2 AAL77539.1 AAP35764.1 ACM84938.1 BAF82729.1 BAG58686.1 CAH05569.1 CAH05570.1 CAH05571.1 CAH05572.1	P46977 Q86XU9 Q8TE35	6S7O[A] β-L-Glcp-(1-1)-<non_carb> 3.50 8B6L[I] 7.60 8PN9[A] 3.61
dolichyl-diphosphooligosaccharide: protein glycotransferase / oligosaccharyltransferase subunit STT3B (SIMP; OST-B)	2.4.99.18	Homo sapiens	AAL71884.1 AAH15880.1 ABA83583.1 ABA84110.1 BAB55370.1 BAC11076.1 BAC11581.1 CAC39710.1 CAE48447.1 CAE91783.1 CAF00240.1 CAF85831.1 CAI72081.1 NP_849193.1	Q8TCJ2	6S7T[A] 3.50
oligosaccharyltransferase STT3 subunit (YGL022w;Stt3;RHK2)	2.4.99.18	Saccharomyces cerevisiae S288c	BAA06079.1 ABC17138.1 CAA96722.1 NP_011493.1	P39007	2LGZ[A] NMR 6C26[A] 3.50 6EZN[F] 3.30 7OCI[F] β-L-Glcp-(1-1)-<non_carb> β-L-Glcp-(1-4)-β-L-Glcp-(1-1)-<non_carb> 3.46 8AGB[A] 8AGC[A] 3.10 8AGE[A] β-L-Glcp-(1-1)-<non_carb> 2.80
CTHT_0009650		Thermochaetoides thermophila DSM 1495	XP_006691489.1		8I9P[BA] 8I9R[GA] 8I9T[UA] 8I9V[WA] 8I9W[WA] 8I9X[CB] 8I9Y[BB] 8I9Z[CB] 8IA0[FB] 8ONZ[D] 8PV1[AB] 8PV2[UA] 8PV3[AB] 8PV4[FB] 8PV5[UA] 8PV6[EB] 8PV7[BB] 8PV8[NA] 8PVK[BB] 8PVL[ZA]
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