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GlycosylTransferase Family 64

Known ActivitiesUDP-GlcNAc: heparan α-N-acetylhexosaminyltransferase (EC 2.4.1.224)
Mechanism Retaining
3D Structure StatusGT-A
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain.
Statistics GenBank accession (196); Uniprot accession (74); PDB accession (4); 3D entries (1); cryst (0)
Summary
All (69) Eukaryota (69) Structure (1 ) Characterized (10)
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) 2.4.1.224
2.4.1.225		 Bos taurus AAC35386.1
AAI26571.1
NP_803462.1		 O77783.1  
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.224
2.4.1.225		 Cricetulus griseus AAF71276.1 Q9JK82  
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225		 Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1		 Q9XZ08  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224
2.4.1.225		 Homo sapiens AAB62283.1
AAH01174.1
ACS08204.1
BAG35949.1
NP_000118.1		 B2R7V2
Q16394.2		  
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223
2.4.1.225		 Homo sapiens AAB67602.1
AAC39598.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12594.1
ACW32787.1
BAA24080.1
BAA25445.2
BAG57702.1
NP_001431.1		 D3DST8
O43909.1
Q53XT3		  
 exostosin-like 1 (Extl1) 2.4.1.224 Homo sapiens AAC51141.1
AAD02840.1
AAF73172.1
AAH65528.1
AAW12597.1
CAI17130.1
NP_004446.1		 Q92935  
 UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Exotosin-like 2) (Extl2;Extr2) 2.4.1.223 Homo sapiens AAC02898.1
AAH14910.1
AAH36015.1
AAH45681.1
AAR61360.1
AAW12598.1
BAA24081.1
BAC04893.1
BAG60404.1
NP_001430.1		 B2R795
D3DT60
Q8IYF4
Q8N8F1
Q9UBQ6		  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225		 Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
NP_000392.1		 B2R5Z6
Q93063.1		  
 α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) 2.4.1.224 Mus musculus AAD42040.1
AAH65073.1
AAW12587.1
BAE23506.1
NP_061258.2		 Q9WVL6  
 α-N-acetylhexosaminyltransferase (Extl2) 2.4.1.- Mus musculus AAG17542.1
AAH31438.1
AAH94444.1
BAB31683.2
BAC26062.1
BAC27649.1
BAE34959.1
BAE36615.1
NP_067363.1		 Q8C089
Q8C197
Q9ES89.1		 1OMX[A,B]
1OMZ[A,B]
1ON6[A,B]
1ON8[A,B]

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.