GlycosylTransferase Family 64

Activities in FamilyGlucuronyl-galactosyl-proteoglycan 4-α-N-acetylglucosaminyltransferase (EC 2.4.1.223);
Glucuronosyl-N-acetylglucosaminyl-proteoglycan α-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.224);
Mechanism Retaining
3D Structure StatusGT-A
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain.
External resourcesGlymap;
Statistics GenBank accession (757); Uniprot accession (31); PDB accession (20); 3D entries (4); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224 Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
NP_000392.1
B2R5Z6
Q6NUL1
Q93063
7SCH[B] 3.10
7SCJ[B] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc
3.40
7SCK[B] β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc
2.80
7UQX[B] 3.30
7UQY[B] 3.00
7ZAY[B] 2.80
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224 Homo sapiens AAB62283.1
AAH01174.1
ACS08204.1
AGV77097.1
AHB20150.1
BAG35949.1
NP_000118.1
B2R7V2
Q16394
7SCH[A] 3.10
7SCJ[A] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc
3.40
7SCK[A] β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc
2.80
7UQX[A] 3.30
7UQY[A] 3.00
7ZAY[A] 2.80
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223 Homo sapiens AAC39598.1
AAB67602.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12594.1
ACW32787.1
ADO22448.1
BAA24080.1
BAA25445.2
BAA25445.3
BAG57702.1
NP_001431.1
A0A384NPY9
D3DST8
O43909
Q53XT3
7AU2[A,B] 2.43
7AUA[A,B] 2.93
8OG1[A] 1.58
8OG4[A,B] 2.10
 UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Extl2) 2.4.1.223 Mus musculus AAG17542.1
AAH31438.1
AAH94444.1
BAB31683.2
BAC26062.1
BAC27649.1
BAE34959.1
BAE36615.1
BAM48568.1
BAM48569.1
NP_067363.1
K0J1C6
Q3TSR0
Q3TXF7
Q8C089
Q8C197
Q9ES89
1OMX[A,B] 2.40
1OMZ[A,B] 2.10
1ON6[A,B] 2.30
1ON8[A,B] β-D-GlcpA-(1-3)-β-D-Galp
2.70
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