GlycosylTransferase Family 64

Activities in FamilyUDP-GlcNAc: heparan α-N-acetylhexosaminyltransferase (EC 2.4.1.224)
Mechanism Retaining
3D Structure StatusGT-A
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain.
External resourcesGlymap;
Statistics GenBank accession (311); Uniprot accession (84); PDB accession (4); 3D entries (1); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Extl2) 2.4.1.223 Mus musculus AAG17542.1
AAH31438.1
AAH94444.1
BAB31683.2
BAC26062.1
BAC27649.1
BAE34959.1
BAE36615.1
BAM48568.1
BAM48569.1
NP_067363.1
Q8C089
Q8C197
Q9ES89
1OMX[A,B] 2.40
1OMZ[A,B] 2.10
1ON6[A,B] 2.30
1ON8[A,B] β-D-GlcpA-(1-3)-β-D-Galp
2.70
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