Activities in Family	Peptidoglycan glycosyltransferase (EC 2.4.1.129);
Mechanism	Inverting
3D Structure Status	lysozyme-type
Catalytic Nucleophile/Base	Glu
Note	There are two categories of enzymes in this family : monofunctional (just the GT51 module) or bifunctional (GT51 module attached to a penicillin-binding transpeptidase module). These enzymes utilise Und-PP-MurAc-(GlcNAc)-pentapeptide as the sugar donor.
Statistics	GenBank accession (100973); Uniprot accession (19); PDB accession (40); 3D entries (10); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
penicillin-binding protein 1a (PonA;Pbp1;AbPBP1a)		Acinetobacter baumannii HUMV-1102	AEK25749.1		3UDF[A,B] 1.70 3UDI[A,B] 2.60 3UDX[A,B] <carb_like_IM2> 2.50 3UE0[A,B] 2.60 3UE1[A,B] 2.73
peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;aq_624)	2.4.1.129	Aquifex aeolicus VF5	AAC06835.1 CBF93872.1 CBF97392.1 NP_213434.1	O66874	2OQO[A] 2.10 3D3H[A] 2.31 3NB6[A] 2.70 3NB7[A] 2.65
murein polymerase (PBP1b;MrcB;PonB;PbfF;b0149;EO53_17580)	2.4.1.129	Escherichia coli str. K-12 substr. MG1655	AIZ92688.1 AAC73260.1 ALI42026.1 AMC97401.1 AUG14952.1 AVI54692.1 AYG20692.1 CAA26098.1 CAA26099.1 NP_414691.1	P02919	3FWL[A] 3.09 3FWM[A] 2.16 3VMA[A] 2.16 5FGZ[A] 2.85 5HL9[A] 2.70 5HLA[A] β-D-Galp-(1-4)-β-D-6-deoxy-GlcpNAc-(1-4)[β-D-Glcp-(1-6)]-β-D-GlcpNAc-(1-2)[<non_carb>-(1-3)]-α-D-Glcp 2.36 5HLB[A] 2.42 5HLD[A] 2.31 6YN0[A] 2.40 7LQ6[A] 3.28
HI0440 / HI_0440		Haemophilus influenzae Rd KW20	CBF97185.1 AAA25007.1 AAC22099.1 CBF93665.1 NP_438601.1		5U2G[A,B] 2.61
bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 (Pbp4;Lmo2229)	2.4.1.129	Listeria monocytogenes EGD-e	NP_465753.1 CAD00307.1	Q8Y547	3ZG7[A,B] 1.99 3ZG8[A,B] 2.09 3ZG9[A,B] 1.80 3ZGA[A,B] 2.00
transglycosylase domain-containing protein		Parvimonas parva	WP_201275244.1		7U4H[A,B] 3.10
SAV1874		Staphylococcus aureus subsp. aureus Mu50	BAB58036.1 AAA18515.1 BAB46794.1 NP_372398.1		5ZZK[A] 2.64
monofunctional glycosyltransferase (Mgt;MgtA;MW1814)	2.4.1.129	Staphylococcus aureus subsp. aureus MW2	BAB95679.1 NP_646631.1	Q7A0I6 Q99T05	3HZS[A] 2.10 3VMQ[A,B] 2.52 3VMR[A] 3.69 3VMS[A,B] 3.20 3VMT[A,B] 2.30 6FTB[A] β-D-Galp-(1-1)-methyl <non_carb>-(1-3)-α-D-Glcp 2.10
bifunctional peptidoglycan glycosyltransferase / transpeptidase penicillin-binding protein 2 (Pbp2;SAOUHSC_01467)	2.4.1.129	Staphylococcus aureus subsp. aureus NCTC 8325	ABD30552.1	Q2FYI0 Q8KHY3 Q9R744	2OLU[A] 2.90 2OLV[A,B] 2.80 3DWK[A,B,C,D] 3.10
penicillin-binding protein 1B (Pbp1b)		Streptococcus pneumoniae R6	AAF04736.1 AAL00711.1 CAA05302.1 NP_359500.1		7ZUH[A] 7ZUI[A] 7ZUJ[A] 7ZUK[A] 7ZUL[A]
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