Known Activities	murein polymerase (EC 2.4.1.129).
Mechanism	Inverting
3D Structure Status	lysozyme-type
Catalytic Nucleophile/Base	Glu
Note	There are two categories of enzymes in this family : monofunctional (just the GT51 module) or bifunctional (GT51 module attached to a penicillin-binding transpeptidase module). These enzymes utilise Und-PP-MurAc-(GlcNAc)-pentapeptide as the sugar donor.
External resources	InterPro; PFAM;
Statistics	GenBank accession (6199); Uniprot accession (3308); PDB accession (18); 3D entries (6); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
penicillin-binding protein 1a (PonA;Pbp1;AbPBP1a)		Acinetobacter baumannii HUMV-1102	AEK25749.1		3UDF[A,B] 3UDI[A,B] 3UDX[A,B] 3UE0[A,B] 3UE1[A,B]
peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;aq_624)	2.4.1.129	Aquifex aeolicus VF5	AAC06835.1 CBF93872.1 CBF97392.1 NP_213434.1	O66874.1	2OQO[A] 3NB6[A] 3NB7[A]
murein polymerase (PBP1b;MrcB;PonB;PbfF;b0149)	2.4.1.129	Escherichia coli K-12 MG1655	AAC73260.1 CAA26098.1 CAA26099.1 NP_414691.1	P02919.2	3FWL[A] 3FWM[A]
monofunctional glycosyltransferase (Mgt;MgtA;MW1814)	2.4.1.129	Staphylococcus aureus subsp. aureus MW2	BAB95679.1 NP_646631.1	Q7A0I6	3HZS[A]
bifunctional peptidoglycan glycosyltransferase / transpeptidase penicillin-binding protein 2 (Pbp2;SAOUHSC_01467)	2.4.1.129	Staphylococcus aureus subsp. aureus NCTC 8325	ABD30552.1	Q2FYI0	2OLU[A] 2OLV[A,B] 3DWK[A,B,C,D]
penicillin-binding protein 1B (Pbp1b)		Streptococcus pneumoniae R6	AAF04736.1 AAL00711.1 CAA05302.1 NP_359500.1	O70038 Q7CRA4	2FFF[A] 2JCH[A] 2JCI[A,B] 2JE5[A,B]

Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II