GlycosylTransferase Family 51

Activities in Familymurein polymerase (EC 2.4.1.129).
Mechanism Inverting
3D Structure Statuslysozyme-type
Catalytic Nucleophile/BaseGlu
NoteThere are two categories of enzymes in this family : monofunctional (just the GT51 module) or bifunctional (GT51 module attached to a penicillin-binding transpeptidase module). These enzymes utilise Und-PP-MurAc-(GlcNAc)-pentapeptide as the sugar donor.
Statistics GenBank accession (27785); Uniprot accession (3452); PDB accession (29); 3D entries (7); cryst (0)
All (26422) Bacteria (26411) Eukaryota (8) unclassified (3) Structure (7) Characterized (15)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 penicillin-binding protein 1a (PonA;Pbp1;AbPBP1a)   Acinetobacter baumannii HUMV-1102 AEK25749.1  
3UDF[A,B] 1.70
3UDI[A,B] 2.60
3UDX[A,B] <carb_like_IM2>
2.50
3UE0[A,B] 2.60
3UE1[A,B] 2.73
 peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;aq_624) 2.4.1.129 Aquifex aeolicus VF5 AAC06835.1
CBF93872.1
CBF97392.1
NP_213434.1
O66874
2OQO[A] 2.10
3NB6[A] 2.70
3NB7[A] 2.65
 murein polymerase (PBP1b;MrcB;PonB;PbfF;b0149;EO53_17580) 2.4.1.129 Escherichia coli str. K-12 substr. MG1655 AIZ92688.1
AAC73260.1
ALI42026.1
AMC97401.1
CAA26098.1
CAA26099.1
NP_414691.1
P02919
3FWL[A] 3.09
3FWM[A] 2.16
3VMA[A] 2.16
5FGZ[A] 2.85
5HL9[A] 2.70
5HLA[A] β-D-Galp-(1-4)-β-D-6-deoxy-GlcpNAc-(1-4)[β-D-Glcp-(1-6)]-β-D-GlcpNAc-(1-2)[<non_carb>-(1-3)]-α-D-Glcp
2.36
5HLB[A] 2.42
5HLD[A] 2.31
 HI0440 / HI_0440   Haemophilus influenzae Rd KW20 AAA25007.1
AAC22099.1
CBF93665.1
CBF97185.1
NP_438601.1
P31776
5U2G[A,B] 2.61
 bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 (Pbp4;Lmo2229) 2.4.1.129 Listeria monocytogenes EGD-e NP_465753.1
CAD00307.1
Q8Y547
3ZG7[A,B] 1.99
3ZG8[A,B] 2.09
3ZG9[A,B] 1.80
3ZGA[A,B] 2.00
 monofunctional glycosyltransferase (Mgt;MgtA;MW1814) 2.4.1.129 Staphylococcus aureus subsp. aureus MW2 BAB95679.1
NP_646631.1
Q7A0I6
3HZS[A] 2.10
3VMQ[A,B] 2.52
3VMR[A] 3.69
3VMS[A,B] 3.20
3VMT[A,B] 2.30
 bifunctional peptidoglycan glycosyltransferase / transpeptidase penicillin-binding protein 2 (Pbp2;SAOUHSC_01467) 2.4.1.129 Staphylococcus aureus subsp. aureus NCTC 8325 ABD30552.1 Q2FYI0
2OLU[A] 2.90
2OLV[A,B] 2.80
3DWK[A,B,C,D] 3.10
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