| Activities in Family | murein polymerase (EC 2.4.1.129). |
|---|---|
| Mechanism | Inverting |
| 3D Structure Status | lysozyme-type |
| Catalytic Nucleophile/Base | Glu |
| Note | There are two categories of enzymes in this family : monofunctional (just the GT51 module) or bifunctional (GT51 module attached to a penicillin-binding transpeptidase module). These enzymes utilise Und-PP-MurAc-(GlcNAc)-pentapeptide as the sugar donor. |
| Statistics | GenBank accession (30406); Uniprot accession (3452); PDB accession (29); 3D entries (7); cryst (0) |
| Bacteria | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| Asuc_1028 | 2.4.1.129 | Actinobacillus succinogenes 130Z | ABR74394.1 | A6VN47 | ||
| peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;aq_624) | 2.4.1.129 | Aquifex aeolicus VF5 | AAC06835.1 CBF93872.1 CBF97392.1 NP_213434.1 |
O66874 | 2OQO[A] 3NB6[A] 3NB7[A] |
|
| Dshi_0142 | 2.4.1.129 | Dinoroseobacter shibae DFL 12 = DSM 16493 | ABV91891.1 | A8LKP8 | ||
| penicillin-binding protein 1A (PonA) | 2.4.1.129 | Enterococcus faecalis JH2-2 | CAC21566.1 | Q9EXN1 | ||
| Monofunctional biosynthetic peptidoglycan transglycosylase (MtgA) | 2.4.1.129 | Escherichia coli str. K-12 substr. MG1655 | AAC76240.1 AAA58010.1 AIZ89782.1 ALI39103.1 AMC96103.1 AUG17915.1 AVI53369.1 NP_417675.1 |
P46022 | ||
| peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;b3396) | 2.4.1.129 | Escherichia coli str. K-12 substr. MG1655 | AAA58193.1 AAC76421.2 AIZ89601.1 ALI38922.1 AMC96283.1 AUG18100.1 AVI53556.1 CAA26100.1 CBF93874.1 CBF97394.1 NP_417855.1 |
P02918 | ||
| murein polymerase (PBP1b;MrcB;PonB;PbfF;b0149;EO53_17580) | 2.4.1.129 | Escherichia coli str. K-12 substr. MG1655 | AIZ92688.1 AAC73260.1 ALI42026.1 AMC97401.1 AUG14952.1 AVI54692.1 CAA26098.1 CAA26099.1 NP_414691.1 |
P02919 | 3FWL[A] 3FWM[A] 3VMA[A] 5FGZ[A] 5HL9[A] 5HLA[A] 5HLB[A] 5HLD[A] |
|
| Monofunctional biosynthetic peptidoglycan transglycosylase | 2.4.1.129 | Klebsiella pneumoniae | CAA90903.1 | Q48465 | ||
| bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 (Pbp4;Lmo2229) | 2.4.1.129 | Listeria monocytogenes EGD-e | NP_465753.1 CAD00307.1 |
Q8Y547 | 3ZG7[A,B] 3ZG8[A,B] 3ZG9[A,B] 3ZGA[A,B] |
|
| monofunctional biosynthetic peptidoglycan transglycosylase (MtgA) | 2.4.-.- | Neisseria gonorrhoeae CH-95 | AAB37748.1 AAC44899.1 |
Q51005 | ||
| peptidoglycan glycosyltransferase / penicillin-binding protein 2 (Pbp2) | 2.4.1.129 | Staphylococcus aureus 209P | AAA74375.1 CBF93854.1 CBF97374.1 |
Q53724 | ||
| monofunctional glycosyltransferase (Mgt) | 2.4.1.129 | Staphylococcus aureus ST446 | AAK83040.1 | Q93Q23 | ||
| monofunctional glycosyltransferase (Mgt;MgtA;MW1814) | 2.4.1.129 | Staphylococcus aureus subsp. aureus MW2 | BAB95679.1 NP_646631.1 |
Q7A0I6 | 3HZS[A] 3VMQ[A,B] 3VMR[A] 3VMS[A,B] 3VMT[A,B] |
|
| bifunctional peptidoglycan glycosyltransferase / transpeptidase penicillin-binding protein 2 (Pbp2;SAOUHSC_01467) | 2.4.1.129 | Staphylococcus aureus subsp. aureus NCTC 8325 | ABD30552.1 | Q2FYI0 | 2OLU[A] 2OLV[A,B] 3DWK[A,B,C,D] |
|
| murein polymerase/penicillin-binding protein 2A (Pbp2A) | 2.4.1.129 | Streptococcus pneumoniae R6 | AAF04735.1 AAL00626.1 NP_359415.1 |
Q8DNB6 Q9RQJ1 |
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