GlycosylTransferase Family 51

Activities in Familymurein polymerase (EC 2.4.1.129).
Mechanism Inverting
3D Structure Statuslysozyme-type
Catalytic Nucleophile/BaseGlu
NoteThere are two categories of enzymes in this family : monofunctional (just the GT51 module) or bifunctional (GT51 module attached to a penicillin-binding transpeptidase module). These enzymes utilise Und-PP-MurAc-(GlcNAc)-pentapeptide as the sugar donor.
Statistics GenBank accession (26823); Uniprot accession (3452); PDB accession (30); 3D entries (8); cryst (0)
All (25456) Bacteria (25445) Eukaryota (8) unclassified (3) Structure (8) Characterized (15)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Asuc_1028 2.4.1.129 Actinobacillus succinogenes 130Z ABR74394.1 A6VN47  
 peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;aq_624) 2.4.1.129 Aquifex aeolicus VF5 AAC06835.1
CBF93872.1
CBF97392.1
NP_213434.1
O66874 2OQO[A]
3NB6[A]
3NB7[A]
 Dshi_0142 2.4.1.129 Dinoroseobacter shibae DFL 12 = DSM 16493 ABV91891.1 A8LKP8  
 penicillin-binding protein 1A (PonA) 2.4.1.129 Enterococcus faecalis JH2-2 CAC21566.1 Q9EXN1  
 Monofunctional biosynthetic peptidoglycan transglycosylase (MtgA) 2.4.1.129 Escherichia coli str. K-12 substr. MG1655 AAC76240.1
AAA58010.1
AIZ89782.1
ALI39103.1
AMC96103.1
NP_417675.1
P46022  
  peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;b3396) 2.4.1.129 Escherichia coli str. K-12 substr. MG1655 AAA58193.1
AAC76421.2
AIZ89601.1
ALI38922.1
AMC96283.1
CAA26100.1
CBF93874.1
CBF97394.1
NP_417855.1
P02918  
 murein polymerase (PBP1b;MrcB;PonB;PbfF;b0149;EO53_17580) 2.4.1.129 Escherichia coli str. K-12 substr. MG1655 AIZ92688.1
AAC73260.1
ALI42026.1
AMC97401.1
CAA26098.1
CAA26099.1
NP_414691.1
P02919 3FWL[A]
3FWM[A]
3VMA[A]
5FGZ[A]
5HL9[A]
5HLA[A]
5HLB[A]
5HLD[A]
 Monofunctional biosynthetic peptidoglycan transglycosylase 2.4.1.129 Klebsiella pneumoniae CAA90903.1 Q48465  
 bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 (Pbp4;Lmo2229) 2.4.1.129 Listeria monocytogenes EGD-e NP_465753.1
CAD00307.1
Q8Y547 3ZG7[A,B]
3ZG8[A,B]
3ZG9[A,B]
3ZGA[A,B]
 monofunctional biosynthetic peptidoglycan transglycosylase (MtgA) 2.4.-.- Neisseria gonorrhoeae CH-95 AAB37748.1
AAC44899.1
Q51005  
 peptidoglycan glycosyltransferase / penicillin-binding protein 2 (Pbp2) 2.4.1.129 Staphylococcus aureus 209P AAA74375.1
CBF93854.1
CBF97374.1
Q53724  
 monofunctional glycosyltransferase (Mgt) 2.4.1.129 Staphylococcus aureus ST446 AAK83040.1 Q93Q23  
 monofunctional glycosyltransferase (Mgt;MgtA;MW1814) 2.4.1.129 Staphylococcus aureus subsp. aureus MW2 BAB95679.1
NP_646631.1
Q7A0I6 3HZS[A]
3VMQ[A,B]
3VMR[A]
3VMS[A,B]
3VMT[A,B]
 bifunctional peptidoglycan glycosyltransferase / transpeptidase penicillin-binding protein 2 (Pbp2;SAOUHSC_01467) 2.4.1.129 Staphylococcus aureus subsp. aureus NCTC 8325 ABD30552.1 Q2FYI0 2OLU[A]
2OLV[A,B]
3DWK[A,B,C,D]
 murein polymerase/penicillin-binding protein 2A (Pbp2A) 2.4.1.129 Streptococcus pneumoniae R6 AAF04735.1
AAL00626.1
NP_359415.1
Q8DNB6
Q9RQJ1
 
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