GlycosylTransferase Family 51

Known Activities	murein polymerase (EC 2.4.1.129).
Mechanism	Inverting
3D Structure Status	lysozyme-type
Catalytic Nucleophile/Base	Glu
Note	There are two categories of enzymes in this family : monofunctional (just the GT51 module) or bifunctional (GT51 module attached to a penicillin-binding transpeptidase module). These enzymes utilise Und-PP-MurAc-(GlcNAc)-pentapeptide as the sugar donor.
External resources	InterPro; PFAM;
Statistics	GenBank accession (6199); Uniprot accession (3308); PDB accession (18); 3D entries (6); cryst (0)

Summary

All (5057) Bacteria (5053) Eukaryota (3) unclassified (1) Structure (6 ) Characterized (15)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
Asuc_1028	2.4.1.129	Actinobacillus succinogenes 130Z	ABR74394.1	A6VN47
peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;aq_624)	2.4.1.129	Aquifex aeolicus VF5	AAC06835.1 CBF93872.1 CBF97392.1 NP_213434.1	O66874.1	2OQO[A] 3NB6[A] 3NB7[A]
Dshi_0142	2.4.1.129	Dinoroseobacter shibae DFL 12	ABV91891.1	A8LKP8
penicillin-binding protein 1A (PonA)	2.3.2.-	Enterococcus faecalis JH2-2	CAC21566.1	Q9EXN1
Monofunctional biosynthetic peptidoglycan transglycosylase (MtgA)	2.4.1.129	Escherichia coli K-12 MG1655	AAA58010.1 AAC76240.1 NP_417675.1	P46022
peptidoglycan glycosyltransferase / penicillin-binding protein 1A (Pbp1A;PonA;MrcA;b3396)	2.4.1.129	Escherichia coli K-12 MG1655	AAA58193.1 AAC76421.2 CAA26100.1 CBF93874.1 CBF97394.1 NP_417855.1	P02918.1
murein polymerase (PBP1b;MrcB;PonB;PbfF;b0149)	2.4.1.129	Escherichia coli K-12 MG1655	AAC73260.1 CAA26098.1 CAA26099.1 NP_414691.1	P02919.2	3FWL[A] 3FWM[A]
Monofunctional biosynthetic peptidoglycan transglycosylase	2.4.1.129	Klebsiella pneumoniae	CAA90903.1	Q48465
bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 (Pbp4;Lmo2229)	2.4.1.129	Listeria monocytogenes EGD-e	CAD00307.1 NP_465753.1	Q8Y547
monofunctional biosynthetic peptidoglycan transglycosylase (MtgA)	2.4.-.-	Neisseria gonorrhoeae CH-95	AAB37748.1 AAC44899.1	Q51005.1
peptidoglycan glycosyltransferase / penicillin-binding protein 2 (Pbp2)	2.4.1.129	Staphylococcus aureus 209P	AAA74375.1 CBF93854.1 CBF97374.1	Q53724
monofunctional glycosyltransferase (Mgt)	2.4.1.129	Staphylococcus aureus ST446	AAK83040.1	Q93Q23
monofunctional glycosyltransferase (Mgt;MgtA;MW1814)	2.4.1.129	Staphylococcus aureus subsp. aureus MW2	BAB95679.1 NP_646631.1	Q7A0I6	3HZS[A]
bifunctional peptidoglycan glycosyltransferase / transpeptidase penicillin-binding protein 2 (Pbp2;SAOUHSC_01467)	2.4.1.129	Staphylococcus aureus subsp. aureus NCTC 8325	ABD30552.1	Q2FYI0	2OLU[A] 2OLV[A,B] 3DWK[A,B,C,D]
murein polymerase/penicillin-binding protein 2A (Pbp2A)	2.4.1.129	Streptococcus pneumoniae R6	AAF04735.1 AAL00626.1 NP_359415.1	Q8DNB6 Q9RQJ1

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.