Glycoside Hydrolase Family 98

Activities in Familyblood-group endo-β-1,4-galactosidase (EC 3.2.1.102); blood group A- and B-cleaving endo-β-1,4-galactosidase (EC 3.2.1.-); endo-β-1,4-xylanase (EC 3.2.1.8); endo-β-1,4-xylanase (EC 3.2.1.8)
Mechanism inverting
Catalytic Nucleophile/BaseAsp+Glu diad
Catalytic Proton DonorGlu
NoteCreated after Anderson et al. (J. Biol. Chem. 2005 280: 7720-7728; PMID:15618227)
External resourcesCAZypedia;
Statistics GenBank accession (143); Uniprot accession (29); PDB accession (16); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endo-β-1,4-galactosidase (CGSSp3BS71_10403;Sp3GH98;EABase) (blood-group A/B-antigen-specific) 3.2.1.102 Streptococcus pneumoniae SP3-BS71 EDK74349.1 A5LBQ0
2WMI[A,B] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp
1.90
2WMJ[A,B] α-D-Galp-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp
2.00
2WMK[A,B] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc
1.90
4D6C[A] 1.59
4D6D[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-α-D-Galp
1.52
4D6E[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp
1.45
4D6F[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-3)-β-D-GlcpNAc
2.03
4D6G[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-α-D-Galp
1.24
4D6H[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-3)-β-D-GlcpNAc
1.65
4D6I[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-3)-β-D-GlcpNAc
1.99
4D6J[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-GlcpNAc
1.98
4D71[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-GlcpNAc
1.77
4D72[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-GlcpNAc
2.11
 endo-β-1,4-galactosidase (SP_2159;SP2159;Sp4GH98) (LewisY-specific) 3.2.1.102 Streptococcus pneumoniae TIGR4 AAK76213.1
AAY71778.1
NP_346573.1
Q97N96
2WMF[A] 1.50
2WMG[A] α-L-Fucp-(1-2)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc
2.30
2WMH[A] α-L-Fucp-(1-2)-β-D-Galp
1.70
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