Activities in Family	blood-group endo-β-1,4-galactosidase (EC 3.2.1.102); blood group A- and B-cleaving endo-β-1,4-galactosidase (EC 3.2.1.-); endo-β-1,4-xylanase (EC 3.2.1.8); endo-β-1,4-xylanase (EC 3.2.1.8)
Mechanism	inverting
Catalytic Nucleophile/Base	Asp+Glu diad
Catalytic Proton Donor	Glu
Note	Created after Anderson et al. (J. Biol. Chem. 2005 280: 7720-7728; PMID:15618227)
External resources	CAZypedia;
Statistics	GenBank accession (197); Uniprot accession (29); PDB accession (16); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
endo-β-1,4-galactosidase (CGSSp3BS71_10403;Sp3GH98;EABase) (blood-group A/B-antigen-specific)	3.2.1.102	Streptococcus pneumoniae SP3-BS71	EDK74349.1	A5LBQ0	2WMI[A,B] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp 1.90 2WMJ[A,B] α-D-Galp-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp 2.00 2WMK[A,B] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc 1.90 4D6C[A] 1.59 4D6D[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-α-D-Galp 1.52 4D6E[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp 1.45 4D6F[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-3)-β-D-GlcpNAc 2.03 4D6G[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-α-D-Galp 1.24 4D6H[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-3)-β-D-GlcpNAc 1.65 4D6I[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-3)-β-D-GlcpNAc 1.99 4D6J[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-GlcpNAc 1.98 4D71[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-GlcpNAc 1.77 4D72[A] α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-GlcpNAc 2.11
endo-β-1,4-galactosidase (SP_2159;SP2159;Sp4GH98) (LewisY-specific)	3.2.1.102	Streptococcus pneumoniae TIGR4	AAK76213.1 AAY71778.1 NP_346573.1	Q97N96	2WMF[A] 1.50 2WMG[A] α-L-Fucp-(1-2)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc 2.30 2WMH[A] α-L-Fucp-(1-2)-β-D-Galp 1.70
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