Glycoside Hydrolase Family 7

Activities in Familyendo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism Retaining
ClanGH-B
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (10567); Uniprot accession (528); PDB accession (84); 3D entries (17); cryst (0)
All (5102) Bacteria (10) Eukaryota (5088) unclassified (4) Structure (17) Characterized (84)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cellobiohydrolase B (CbhB;AFUA_6G11610) (Cel7A) 3.2.1.176 Aspergillus fumigatus Af293 EAL89006.1 Q4WM08
4V1Z[A] 1.78
4V20[A] β-D-Glcp-(1-4)-β-D-Glcp2F
1.50
 cellobiohydrolase (CBHI;DAPPUDRAFT_347598) (Cel7A)   Daphnia pulex EFX85218.1  
4XNN[A,B] 1.90
5MCC[A,B] 2.00
5MCD[A,B] 2.00
5MCE[A,B] 2.00
5MCF[A,B] 2.00
5MCH[A,B] 2.00
5MCI[A,B] 2.00
5MCJ[A,B] 2.00
5MCK[A,B] 2.00
5MCL[A,B] 2.00
5MCM[A,B] 2.00
5MCN[A,B] 2.00
 cellobiohydrolase I (CbhA;DdiCel7A;DDB_G0268446) (Cel7A) 3.2.1.176 Dictyostelium discoideum AX4 EAL73676.1  
4ZZQ[A] 2.10
 cellobiohydrolase (DpuCel7A;DICPUDRAFT_151874) 3.2.1.176 Dictyostelium purpureum QSDP1 EGC35742.1  
4ZZP[A,B] 2.70
 endo-β-1,4-glucanase I (EG I;Eg1;Fof7) (Cel7B) 3.2.1.4 Fusarium oxysporum AAA65586.1
AAE25069.1
AAG09047.1
P46237
1OVW[A,B,C,D] β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp1S4S
2.70
2OVW[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
2.30
3OVW[A,B] 2.30
4OVW[A,B] 2.30
 CBH1   Geotrichum candidum 3C AIO10971.1  
4ZZT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.56
4ZZU[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp4S
1.44
4ZZV[A] 1.37
4ZZW[A] β-D-Glcp-(1-4)-β-D-Glcp
1.50
5AMP[A] 2.12
 cellobiohydrolase 1 (HirCel7A;38802) (Cel7A) 3.2.1.176 Heterobasidion irregulare TC 32-1    
2XSP[A] α-D-Xylp
1.70
2YG1[A,B] 1.90
 cellobiohydrolase (Cbh-1;HgtCel7A) (Cel7A) 3.2.1.176 Humicola grisea var. thermoidea IFO9854 / CBS 225.63 BAA09785.1 Q12621
4CSI[A,B] 1.80
 endoglucanase I (EG I;EG1) (Cel7B) 3.2.1.4 Humicola insolens AAE25068.1
AAE25070.1
P56680
1A39[A] 2.20
1DYM[A] 1.75
1OJI[A] 2.15
1OJJ[A,B] β-D-Galp-(1-4)-α-D-Glcp
β-D-Galp-(1-4)-β-D-Glcp
1.4
1OJK[A,B] β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
1.5
2A39[A,B] 2.20
 cellobiohydrolase (GH7B;LqCel7B) (Cel7B) 3.2.1.176 Limnoria quadripunctata ADB85438.1 D4HRL0
4GWA[A,B] 1.60
4HAP[A,B] β-D-Glcp-(1-4)-β-D-Glcp
1.60
4HAQ[A,B] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
1.90
4IPM[A] β-D-Glcp-(1-4)-β-D-Glcp4S
1.14
 cellobiohydrolase (Gh7;MaCel7B) (Cel7B) 3.2.1.176 Melanocarpus albomyces CBS 638.94 CAD56667.1
AAU96164.1
CAD79785.1
CDF76454.1
Q8J0K6
2RFW[A,B,C,D] 1.60
2RFY[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
1.70
2RFZ[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.80
2RG0[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.10
 cellobiohydrolase I-2 (CBH58;CbhI.2;CbhI-4;PcCel7D) (Cel7D) 3.2.1.176 Phanerochaete chrysosporium CAA82761.1
AAA19802.1
CAA77789.1
CAA77795.1
CAA80252.1
CAA82762.1
Q09431
Q7LHI2
1GPI[A] 1.32
1H46[X] 1.52
1Z3T[A] β-D-Glcp-(1-4)-β-D-Glcp
1.70
1Z3V[A] β-D-Galp-(1-4)-β-D-Glcp
1.61
1Z3W[A] β-D-Glcp-(1-1)-<non_carb>
1.70
 cellobiohydrolase 1 (Cbh1A;CBH IB;TeCbh1;ReCel7A) (Cel7A) 3.2.1.176 Rasamsonia emersonii IMI 392299 AAL89553.1
AAL33603.2
Q8TFL9
1Q9H[A] 2.35
3PFJ[A] 1.36
3PFX[A] β-D-Glcp-(1-4)-β-D-Glcp
1.26
3PFZ[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.10
3PL3[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.18
 cellobiohydrolase I (Cbh1) 3.2.1.176 Talaromyces funiculosus NCL1 ADX60067.1  
4XEB[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.70
 cellobiohydrolase I (Cbh1;ThCBHI;ThCel7A) (Cel7A) 3.2.1.176 Trichoderma harzianum FP 108 / IOC-3844 AAF36391.1 Q9P8P3
2Y9L[A] 1.67
2Y9N[A] 2.89
2YOK[A] 1.67
 cellobiohydrolase I / chitosanase (CBHI;Cbh1;CBH-I;TrCel7A;HjCel7A;TreCel7A) (Cel7A) 3.2.1.176
3.2.1.132
Trichoderma reesei CAH10320.1
AAE25072.1
AAR60512.1
CAF32516.1
CAF32517.1
CAF32518.1
CAR96030.1
P62694
1CEL[A,B] β-D-Glcp-(1-1)-<non_carb>
1.80
1DY4[A] 1.90
1EGN[A] 1.60
1Q2B[A] 1.60
1Q2E[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.75
2CEL[A,B] 2.00
2V3I[A] 1.05
3CEL[A] β-D-Glcp-(1-4)-β-D-Glcp
2.00
4C4C[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.45
4C4D[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.32
4CEL[A,B] 2.20
4D5I[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.42
4D5J[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.50
4D5O[A] β-D-Galp-(1-4)-β-D-Glcp
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.52
4D5P[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.89
4D5Q[A] β-D-Xylp
β-D-Xylp-(1-1)-<non_carb>
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-1)-<non_carb>
1.68
4D5V[A] β-D-Xylp-(1-1)-<non_carb>
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.62
4P1H[A] 1.50
4P1J[A] β-D-Glcp-(1-4)-β-D-Glcp
2.62
4UWT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.20
4V0Z[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.70
5CEL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
5OA5[A,B] 2.10
5TC9[A] 1.60
6CEL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.70
7CEL[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
8CEL[nd]
 endo-β-1,4-glucanase I (EGI;Egl1;EG-I;TrCel7B) (Cel7B) 3.2.1.4 Trichoderma reesei AAA34212.1
AAE25071.1
AAQ24882.1
AAR60514.1
ABE22093.1
CAR96034.1
CAR96035.1
P07981
1EG1[A,C] 3.60
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