Glycoside Hydrolase Family 7

Known Activities	endo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism	Retaining
Clan	GH-B
3D Structure Status	β-jelly roll
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resources	CAZypedia; HOMSTRAD; InterPro; PFAM; PRINTS;
Statistics	GenBank accession (10352); Uniprot accession (521); PDB accession (41); 3D entries (9); cryst (1)

Summary

All (4925) Eukaryota (4920) unclassified (5) Structure (9 - 1 cryst) Characterized (73)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
endo-β-1,4-glucanase I (EG I;Eg1;Fof7) (Cel7B)	3.2.1.4	Fusarium oxysporum	AAA65586.1 AAE25069.1 AAG09047.1	P46237	1OVW[A,B,C,D] 2OVW[A,B,C,D] 3OVW[A,B] 4OVW[A,B]
cellobiohydrolase 1 (Cel7A)		Heterobasidion annosum			2XSP[A]
endoglucanase I (EG I;EG1) (Cel7B)	3.2.1.4	Humicola insolens	AAE25068.1 AAE25070.1	P56680	1A39[A] 1DYM[A] 1OJI[A] 1OJJ[A,B] 1OJK[A,B] 2A39[A,B]
endo-β-1,4-glucanase I (EGI;Egl1;EG-I) (Cel7B)	3.2.1.4	Hypocrea jecorina	AAA34212.1 AAE25071.1 AAQ24882.1 AAR60514.1 ABE22093.1 CAR96034.1 CAR96035.1	P07981.1	1EG1[A,C]
cellobiohydrolase I / chitosanase (CBHI;Cbh1;CBH-I) (Cel7A)	3.2.1.132 3.2.1.176	Hypocrea jecorina L27	AAE25072.1 AAR60512.1 CAF32516.1 CAF32517.1 CAF32518.1 CAH10320.1 CAR96030.1	P62694.1	1CEL[A,B] 1DY4[A] 1EGN[A] 1EK7 1I5M 1Q2B[A] 1Q2E[A,B] 2CEL[A,B] 2V3I[A] 3CEL[A] 4CEL[A,B] 5CEL[A] 6CEL[A] 7CEL[A] 8CEL
cellobiohydrolase I (Cbh1;ThCBHI;ThCel7A) (Cel7A)	3.2.1.176	Hypocrea lixii FP 108 / IOC-3844	AAF36391.1	Q9P8P3	cryst
cellobiohydrolase (Cel7B)	3.2.1.176	Melanocarpus albomyces	AAU96164.1 CAD56667.1 CAD79785.1	Q8J0K6	2RFW[A,B,C,D] 2RFY[A,B,C,D] 2RFZ[A,B,C,D] 2RG0[A,B,C,D]
cellobiohydrolase I-2 (Cbh58;CbhI.2;CbhI-4) (Cel7D)	3.2.1.176	Phanerochaete chrysosporium	AAA19802.1 CAA77789.1 CAA77795.1 CAA80252.1 CAA82761.1 CAA82762.1	Q09431 Q7LHI2	1GPI[A] 1H46[X] 1Z3T[A] 1Z3V[A] 1Z3W[A]
cellobiohydrolase 1 (Cbh1A;CBH IB) (Cel7A)	3.2.1.176	Talaromyces emersonii IMI 392299	AAL33603.2 AAL89553.1	Q8TFL9	1Q9H[A] 3PFJ[A] 3PFX[A] 3PFZ[A] 3PL3[A]