Activities in Family	Chitosanase (EC 3.2.1.132); Reducing end-acting cellobiohydrolase (EC 3.2.1.176); Endo-β-1,4-glucanase (EC 3.2.1.4); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Mechanism	Retaining e
Clan	GH-B
3D Structure Status	β-jelly roll
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resources	CAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (10829); Uniprot accession (105); PDB accession (96); 3D entries (22); cryst (0)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
cellobiohydrolase B (CbhB;AFUA_6G11610) (Cel7A)		Aspergillus fumigatus Af293	EAL89006.1 BCV68559.1		4V1Z[A] 1.78 4V20[A] β-D-Glcp-(1-4)-β-D-Glcp2F 1.50
cellobiohydrolase (CBHI;DAPPUDRAFT_347598) (Cel7A)		Daphnia pulex	EFX85218.1		4XNN[A,B] 1.90 5MCC[A,B] 2.00 5MCD[A,B] 2.00 5MCE[A,B] 2.00 5MCF[A,B] 2.00 5MCH[A,B] 2.00 5MCI[A,B] 2.00 5MCJ[A,B] 2.00 5MCK[A,B] 2.00 5MCL[A,B] 2.00 5MCM[A,B] 2.00 5MCN[A,B] 2.00
cellobiohydrolase I (CbhA;DdiCel7A;DDB_G0268446) (Cel7A)	3.2.1.176	Dictyostelium discoideum AX4	EAL73676.1	Q55FE6	4ZZQ[A] 2.10
cellobiohydrolase (DpuCel7A;DICPUDRAFT_151874)	3.2.1.176	Dictyostelium purpureum QSDP1	EGC35742.1	F0ZJZ1	4ZZP[A,B] 2.70
endo-β-1,4-glucanase I (EG I;Eg1;Fof7) (Cel7B)	3.2.1.4	Fusarium oxysporum	AAA65586.1 AAE25069.1 AAG09047.1	P46237 Q9HGT3	1OVW[A,B,C,D] β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp1S4S 2.70 2OVW[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp 2.30 3OVW[A,B] 2.30 4OVW[A,B] 2.30
cellobiohydrolase (GcaCel7A; CBH1) (Cel7A)	3.2.1.176	Geotrichum candidum 3C	AIO10971.1	A0A088T0J9	4ZZT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.56 4ZZU[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp4S 1.44 4ZZV[A] 1.37 4ZZW[A] β-D-Glcp-(1-4)-β-D-Glcp 1.50 5AMP[A] 2.12
cellobiohydrolase 1 (HirCel7A;38802) (Cel7A)	3.2.1.176	Heterobasidion irregulare TC 32-1		I1SB08	2XSP[A] α-D-Xylp 1.70 2YG1[A,B] 1.90
cellobiohydrolase (Cbh-1;HgtCel7A) (Cel7A)	3.2.1.176	Humicola grisea var. thermoidea IFO9854 / CBS 225.63	BAA09785.1	P15828 Q12621	4CSI[A,B] 1.80
endoglucanase I (EG I;EG1) (Cel7B)	3.2.1.4	Humicola insolens	AAE25068.1 AAE25070.1	P56680	1A39[A] 2.20 1DYM[A] 1.75 1OJI[A] 2.15 1OJJ[A,B] β-D-Galp-(1-4)-α-D-Glcp β-D-Galp-(1-4)-β-D-Glcp 1.4 1OJK[A,B] β-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp 1.5 2A39[A,B] 2.20 6YOZ[AAA,BBB] 6YP1[AAA]
cellobiohydrolase (GH7B; LqCel7B) (Cel7B)	3.2.1.176	Limnoria quadripunctata	ADB85438.1	D4HRL0	4GWA[A,B] 1.60 4HAP[A,B] β-D-Glcp-(1-4)-β-D-Glcp 1.60 4HAQ[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 1.90 4IPM[A] β-D-Glcp-(1-4)-β-D-Glcp4S 1.14
cellobiohydrolase (Gh7;MaCel7B) (Cel7B)	3.2.1.176	Melanocarpus albomyces CBS 638.94	CAD56667.1 AAU96164.1 CAD79785.1 CDF76454.1	Q8J0K6	2RFW[A,B,C,D] 1.60 2RFY[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp 1.70 2RFZ[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.80 2RG0[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.10
cellobiohydrolase I-2 (CBH58; CbhI.2; CbhI-4; PcCel7D) (Cel7D)	3.2.1.176	Phanerochaete chrysosporium	CAA82761.1 AAA19802.1 CAA77789.1 CAA77795.1 CAA80252.1 CAA82762.1	Q09431 Q7LHI2 Q7LHI7 Q7LHI8 Q7LIJ0	1GPI[A] 1.32 1H46[X] 1.52 1Z3T[A] β-D-Glcp-(1-4)-β-D-Glcp 1.70 1Z3V[A] β-D-Galp-(1-4)-β-D-Glcp 1.61 1Z3W[A] β-D-Glcp-(1-1)-<non_carb> 1.70
endo-β-1,4-glucanase (Egl7A)		Rasamsonia emersonii CBS 394.64	AHL20272.1 CAJ75962.1		6SU8[A,B,C] 2.48
cellobiohydrolase 1 (Cbh1A;CBH IB;TeCbh1;ReCel7A) (Cel7A)	3.2.1.176	Rasamsonia emersonii IMI 392299	AAL89553.1 AAL33603.2	Q8TFL9	1Q9H[A] 2.35 3PFJ[A] 1.36 3PFX[A] β-D-Glcp-(1-4)-β-D-Glcp 1.26 3PFZ[A] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.10 3PL3[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.18
cellobiohydrolase I (Cbh1)		Talaromyces funiculosus NCL1	ADX60067.1		4XEB[A] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.70
MYCTH_109566		Thermothelomyces thermophilus ATCC 42464	AEO55544.1		5W11[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 2.31
cellobiohydrolase (TatCel7A) (Cel7A)		Trichoderma atroviride IMI 206040	EHK46168.1		5O59[A,B] α-D-4-deoxy-Glcp β-D-4-deoxy-Glcp1SH β-D-Glcp1SH 1.75 5O5D[A,B] 1.72
endo-β-1,4-glucanase I (ThCel7B) (Cel7B)	3.2.1.4	Trichoderma harzianum CBS 226.95	PTB50088.1	A0A2N1LTK3 A0A2T3ZZ88	5W0A[A,B] 2.90
cellobiohydrolase I (Cbh1;ThCBHI;ThCel7A) (Cel7A)	3.2.1.176	Trichoderma harzianum FP 108 / IOC-3844	AAF36391.1	Q9P8P3	2Y9L[A] 1.67 2Y9N[A] 2.89 2YOK[A] 1.67
cellobiohydrolase I / chitosanase (CBHI;Cbh1;CBH-I;TrCel7A;HjCel7A;TreCel7A) (Cel7A)	3.2.1.176 3.2.1.132	Trichoderma reesei	CAH10320.1 AAE25072.1 AAR60512.1 CAF32516.1 CAF32517.1 CAF32518.1 CAR96030.1	G0RVK1 P62694	1CEL[A,B] β-D-Glcp-(1-1)-<non_carb> 1.80 1DY4[A] 1.90 1EGN[A] 1.60 1Q2B[A] 1.60 1Q2E[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl 1.75 2CEL[A,B] 2.00 2V3I[A] 1.05 2V3R[A] 1.60 3CEL[A] β-D-Glcp-(1-4)-β-D-Glcp 2.00 4C4C[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.45 4C4D[A] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU 1.32 4CEL[A,B] 2.20 4D5I[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.42 4D5J[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.50 4D5O[A] β-D-Galp-(1-4)-β-D-Glcp β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.52 4D5P[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.89 4D5Q[A] β-D-Xylp β-D-Xylp-(1-1)-<non_carb> β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-1)-<non_carb> 1.68 4D5V[A] β-D-Xylp-(1-1)-<non_carb> β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.62 4P1H[A] 1.50 4P1J[A] β-D-Glcp-(1-4)-β-D-Glcp 2.62 4UWT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb> 1.20 4V0Z[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb> 1.70 5CEL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.90 5OA5[A,B] 2.10 5TC9[A] 1.60 6CEL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.70 6GRN[A] 1.79 7CEL[A] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.90 7NYT[A] β-D-Galp-(1-4)-β-D-Glcp β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb> 1.09 7OC8[A] β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb> 1.60 8CEL[nd]
endo-β-1,4-glucanase I (EGI; Egl1; EG-I; TrCel7B) (Cel7B)	3.2.1.4	Trichoderma reesei	AAA34212.1 AAE25071.1 AAQ24882.1 AAR60514.1 ABE22093.1 CAR96034.1 CAR96035.1	P07981	1EG1[A,C] 3.60
cellobiohydrolase (cel7A;TRIREDRAFT_123989)	3.2.1.176	Trichoderma reesei QM6a	EGR44817.1	G0RVK1	6RWF[A] 1.64
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