Glycoside Hydrolase Family 7

Activities in Familyendo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism Retaining
ClanGH-B
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (10794); Uniprot accession (100); PDB accession (96); 3D entries (22); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cellobiohydrolase B (CbhB;AFUA_6G11610) (Cel7A)   Aspergillus fumigatus Af293 EAL89006.1
BCV68559.1
 
4V1Z[A] 1.78
4V20[A] β-D-Glcp-(1-4)-β-D-Glcp2F
1.50
 cellobiohydrolase (CBHI;DAPPUDRAFT_347598) (Cel7A)   Daphnia pulex EFX85218.1  
4XNN[A,B] 1.90
5MCC[A,B] 2.00
5MCD[A,B] 2.00
5MCE[A,B] 2.00
5MCF[A,B] 2.00
5MCH[A,B] 2.00
5MCI[A,B] 2.00
5MCJ[A,B] 2.00
5MCK[A,B] 2.00
5MCL[A,B] 2.00
5MCM[A,B] 2.00
5MCN[A,B] 2.00
 cellobiohydrolase I (CbhA;DdiCel7A;DDB_G0268446) (Cel7A) 3.2.1.176 Dictyostelium discoideum AX4 EAL73676.1 Q55FE6
4ZZQ[A] 2.10
 cellobiohydrolase (DpuCel7A;DICPUDRAFT_151874) 3.2.1.176 Dictyostelium purpureum QSDP1 EGC35742.1 F0ZJZ1
4ZZP[A,B] 2.70
 endo-β-1,4-glucanase I (EG I;Eg1;Fof7) (Cel7B) 3.2.1.4 Fusarium oxysporum AAA65586.1
AAE25069.1
AAG09047.1
P46237
Q9HGT3
1OVW[A,B,C,D] β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp1S4S
2.70
2OVW[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
2.30
3OVW[A,B] 2.30
4OVW[A,B] 2.30
 CBH1   Geotrichum candidum 3C AIO10971.1  
4ZZT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.56
4ZZU[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp4S
1.44
4ZZV[A] 1.37
4ZZW[A] β-D-Glcp-(1-4)-β-D-Glcp
1.50
5AMP[A] 2.12
 cellobiohydrolase 1 (HirCel7A;38802) (Cel7A) 3.2.1.176 Heterobasidion irregulare TC 32-1   I1SB08
2XSP[A] α-D-Xylp
1.70
2YG1[A,B] 1.90
 cellobiohydrolase (Cbh-1;HgtCel7A) (Cel7A) 3.2.1.176 Humicola grisea var. thermoidea IFO9854 / CBS 225.63 BAA09785.1 P15828
Q12621
4CSI[A,B] 1.80
 endoglucanase I (EG I;EG1) (Cel7B) 3.2.1.4 Humicola insolens AAE25068.1
AAE25070.1
P56680
1A39[A] 2.20
1DYM[A] 1.75
1OJI[A] 2.15
1OJJ[A,B] β-D-Galp-(1-4)-α-D-Glcp
β-D-Galp-(1-4)-β-D-Glcp
1.4
1OJK[A,B] β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
1.5
2A39[A,B] 2.20
6YOZ[AAA]
6YP1[AAA]
 cellobiohydrolase (GH7B;LqCel7B) (Cel7B) 3.2.1.176 Limnoria quadripunctata ADB85438.1 D4HRL0
4GWA[A,B] 1.60
4HAP[A,B] β-D-Glcp-(1-4)-β-D-Glcp
1.60
4HAQ[A,B] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
1.90
4IPM[A] β-D-Glcp-(1-4)-β-D-Glcp4S
1.14
 cellobiohydrolase (Gh7;MaCel7B) (Cel7B) 3.2.1.176 Melanocarpus albomyces CBS 638.94 CAD56667.1
AAU96164.1
CAD79785.1
CDF76454.1
Q8J0K6
2RFW[A,B,C,D] 1.60
2RFY[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
1.70
2RFZ[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.80
2RG0[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.10
 cellobiohydrolase I-2 (CBH58;CbhI.2;CbhI-4;PcCel7D) (Cel7D) 3.2.1.176 Phanerochaete chrysosporium CAA82761.1
AAA19802.1
CAA77789.1
CAA77795.1
CAA80252.1
CAA82762.1
Q09431
Q7LHI2
Q7LHI7
Q7LHI8
Q7LIJ0
1GPI[A] 1.32
1H46[X] 1.52
1Z3T[A] β-D-Glcp-(1-4)-β-D-Glcp
1.70
1Z3V[A] β-D-Galp-(1-4)-β-D-Glcp
1.61
1Z3W[A] β-D-Glcp-(1-1)-<non_carb>
1.70
 endo-β-1,4-glucanase (Egl7A)   Rasamsonia emersonii CBS 394.64 AHL20272.1
CAJ75962.1
 
6SU8[A,B,C] 2.48
 cellobiohydrolase 1 (Cbh1A;CBH IB;TeCbh1;ReCel7A) (Cel7A) 3.2.1.176 Rasamsonia emersonii IMI 392299 AAL89553.1
AAL33603.2
Q8TFL9
1Q9H[A] 2.35
3PFJ[A] 1.36
3PFX[A] β-D-Glcp-(1-4)-β-D-Glcp
1.26
3PFZ[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.10
3PL3[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.18
 cellobiohydrolase I (Cbh1)   Talaromyces funiculosus NCL1 ADX60067.1  
4XEB[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.70
 MYCTH_109566   Thermothelomyces thermophilus ATCC 42464 AEO55544.1  
5W11[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
2.31
 cellobiohydrolase (TatCel7A) (Cel7A)   Trichoderma atroviride IMI 206040 EHK46168.1  
5O59[A,B] α-D-4-deoxy-Glcp
β-D-4-deoxy-Glcp1SH
β-D-Glcp1SH
1.75
5O5D[A,B] 1.72
 endo-β-1,4-glucanase I (ThCel7B) (Cel7B) 3.2.1.4 Trichoderma harzianum CBS 226.95 PTB50088.1  
5W0A[A,B] 2.90
 cellobiohydrolase I (Cbh1;ThCBHI;ThCel7A) (Cel7A) 3.2.1.176 Trichoderma harzianum FP 108 / IOC-3844 AAF36391.1 Q9P8P3
2Y9L[A] 1.67
2Y9N[A] 2.89
2YOK[A] 1.67
 cellobiohydrolase I / chitosanase (CBHI;Cbh1;CBH-I;TrCel7A;HjCel7A;TreCel7A) (Cel7A) 3.2.1.176
3.2.1.132
Trichoderma reesei CAH10320.1
AAE25072.1
AAR60512.1
CAF32516.1
CAF32517.1
CAF32518.1
CAR96030.1
G0RVK1
P62694
1CEL[A,B] β-D-Glcp-(1-1)-<non_carb>
1.80
1DY4[A] 1.90
1EGN[A] 1.60
1Q2B[A] 1.60
1Q2E[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.75
2CEL[A,B] 2.00
2V3I[A] 1.05
2V3R[A] 1.60
3CEL[A] β-D-Glcp-(1-4)-β-D-Glcp
2.00
4C4C[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.45
4C4D[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.32
4CEL[A,B] 2.20
4D5I[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.42
4D5J[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.50
4D5O[A] β-D-Galp-(1-4)-β-D-Glcp
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.52
4D5P[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.89
4D5Q[A] β-D-Xylp
β-D-Xylp-(1-1)-<non_carb>
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-1)-<non_carb>
1.68
4D5V[A] β-D-Xylp-(1-1)-<non_carb>
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.62
4P1H[A] 1.50
4P1J[A] β-D-Glcp-(1-4)-β-D-Glcp
2.62
4UWT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.20
4V0Z[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.70
5CEL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
5OA5[A,B] 2.10
5TC9[A] 1.60
6CEL[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.70
6GRN[A] 1.79
7CEL[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
7NYT[A] β-D-Galp-(1-4)-β-D-Glcp
β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.09
7OC8[A] β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.60
8CEL[nd]
 endo-β-1,4-glucanase I (EGI;Egl1;EG-I;TrCel7B) (Cel7B) 3.2.1.4 Trichoderma reesei AAA34212.1
AAE25071.1
AAQ24882.1
AAR60514.1
ABE22093.1
CAR96034.1
CAR96035.1
P07981
1EG1[A,C] 3.60
 cellobiohydrolase (cel7A;TRIREDRAFT_123989) 3.2.1.176 Trichoderma reesei QM6a EGR44817.1 G0RVK1
6RWF[A] 1.64
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