Glycoside Hydrolase Family 7

Activities in Familyendo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism Retaining
ClanGH-B
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (10794); Uniprot accession (100); PDB accession (96); 3D entries (22); cryst (0)
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 cellobiohydrolase (Cbh1;ActCbh1) (Cel7A) 3.2.1.176 pubmed
Acremonium thermophilum ALKO4245 CAM98445.1 A7WNT9  
 cellobiohydrolase (Cel7B) 3.2.1.176 pubmed
Acremonium thermophilum ALKO4245 CAM98446.1 A7WNU0  
 cellobiohydrolase I / chitosanase (CBHI) 3.2.1.176
3.2.1.132
doi
doi
Aspergillus aculeatus F-50 BAA25183.1 O59843  
 cellobiohydrolase (Cbh1;NFIA_057300) 3.2.1.176 pubmed
Aspergillus fischeri NRRL 181 EAW16381.1
XP_001258278.1
A1DNL0  
 endo-β-1,4-glucanase (Af-EGL7; AFUA_6G01800; Afu6g01800) 3.2.1.4 pubmed
Aspergillus fumigatus Af293 EAL85859.1    
 cellobiohydrolase (CbhB) 3.2.1.176 pubmed
Aspergillus nidulans AAM54070.1 Q8NK02  
 cellobiohydrolase I (CBHI;CbhB;AN0494.2) 3.2.1.176 pubmed
Aspergillus nidulans FGSC A4 EAA66593.1 Q8NK02  
 endo-β-1,4-glucanase (EglB;AN3418.2) 3.2.1.4 pubmed
Aspergillus nidulans FGSC A4 EAA63386.1 C8VHK3
Q5B7R2
 
 cellobiohydrolase B (CbhB;An01g11660) 3.2.1.176 pubmed
Aspergillus niger CBS 513.88 AAF04492.1
AAP66264.1
CAK44068.1
A2QAI7
Q9UVS8
 
 cellobiohydrolase A (CbhA;An07g09330) 3.2.1.176 pubmed
Aspergillus niger CBS 513.88 AAF04491.1
AAP66263.1
AAR79028.1
CAK39699.1
A2QPG2
Q9UVS9
 
 endo-β-1,4-glucanase (CelB) 3.2.1.4 pubmed
Aspergillus oryzae KBN616 BAA22589.1 F5BB84
O13455
Q2TX26
 
 cellobiohydrolase (Cbh-1) 3.2.1.176 pubmed
Athelia rolfsii BAC81967.1 Q76G53  
 endo-β-1,4-glucanase (COCSADRAFT_201124) 3.2.1.4 pubmed
Bipolaris sorokiniana ND90Pr EMD62476.1    
 endo-β-1,3-1,4-glucanase (Bgl7A) 3.2.1.4
3.2.1.73
pubmed
pubmed
Bispora sp. MEY-1 / CGMCC 2500 ACT53749.1 D2DRB6  
 cellobiohydrolase Ia (Cbh1a;CBH Ia) (Cel7A) 3.2.1.176 doi
Chrysosporium lucknowense AAQ38146.1
ACH15004.1
ACH15013.1
   
 endo-β-1,4-glucanase (CLhgEG1) 3.2.1.4 pubmed
Coptotermes lacteus symbiont WH2002 BAC07551.1 Q8MXY2  
 endo-β-1,4-glucanase (CLhgEG2) 3.2.1.4 pubmed
Coptotermes lacteus symbiont WH2002 BAC07552.1 Q8MXY1  
 cellobiohydrolase I (CBH1;Cel7) (Cel7B) 3.2.1.176 pubmed
Dichomitus squalens FBCC312 CDJ79665.1 U6NEV9  
 cellobiohydrolase I (CbhA;DdiCel7A;DDB_G0268446) (Cel7A) 3.2.1.176 pubmed
Dictyostelium discoideum AX4 EAL73676.1 Q55FE6 4ZZQ[A]
 cellobiohydrolase (DpuCel7A;DICPUDRAFT_151874) 3.2.1.176 pubmed
Dictyostelium purpureum QSDP1 EGC35742.1 F0ZJZ1 4ZZP[A,B]
 cellobiohydrolase (FvCel7B) (Cel7B) 3.2.1.176 doi
Flammulina velutipes Fv-1 BAJ07535.1 D5MSJ4  
 cellobiohydrolase (FvCel7A) (Cel7A) 3.2.1.176 doi
Flammulina velutipes Fv-1 BAJ07534.1 D5MSJ3  
 endo-β-1,4-glucanase I (EG I;Eg1;Fof7) (Cel7B) 3.2.1.4 pubmed
Fusarium oxysporum AAA65586.1
AAE25069.1
AAG09047.1
P46237
Q9HGT3
1OVW[A,B,C,D]
2OVW[A,B,C,D]
3OVW[A,B]
4OVW[A,B]
 cellobiohydrolase I (CbhI) 3.2.1.176 pubmed
Fusicoccum sp. BCC4124 ABS82449.1 A7LN91  
 cellobiohydrolase 1 (HirCel7A;38802) (Cel7A) 3.2.1.176 pubmed
Heterobasidion irregulare TC 32-1   I1SB08 2XSP[A]
2YG1[A,B]
 endoglucanase 3 (HmEG3) (fragment) 3.2.1.4 pubmed
Holomastigotoides mirabile BAB64565.1 Q95P29  
 endoglucanase 2 (HmEG2) 3.2.1.4 pubmed
Holomastigotoides mirabile BAB64564.1 Q95P30  
 endoglucanase 1 (HmEG1) 3.2.1.4 pubmed
Holomastigotoides mirabile BAB64563.1 Q95P31  
 cellobiohydrolase I (Cbh1.1;Cbh1;Cbh-1;HgCbh1) (Cel7A) 3.2.1.176 pubmed
Humicola grisea var. thermoidea CAA35159.1 P15828  
 endo-β-1,4-glucanase I (Egl1;EG-I) 3.2.1.4 pubmed
Humicola grisea var. thermoidea BAA09786.1 Q12622  
 cellobiohydrolase I.2 (Cbh1.2) 3.2.1.176 pubmed
Humicola grisea var. thermoidea AAD31545.1
AAD11942.1
AAN19007.1
O94093
Q7LV60
 
 cellobiohydrolase I (Exo1) 3.2.1.176 pubmed
Humicola grisea var. thermoidea IFO9854 BAA74517.1 O93780  
 cellobiohydrolase (Cbh-1;HgtCel7A) (Cel7A) 3.2.1.176 pubmed
Humicola grisea var. thermoidea IFO9854 / CBS 225.63 BAA09785.1 P15828
Q12621
4CSI[A,B]
 endoglucanase I (EG I;EG1) (Cel7B) 3.2.1.4 pubmed
Humicola insolens AAE25068.1
AAE25070.1
P56680 BBB[nd]
1A39[A]
1DYM[A]
1OJI[A]
1OJJ[A,B]
1OJK[A,B]
2A39[A,B]
6YOZ[AAA]
6YP1[AAA]
 exo-cellulase (Cel1;Ex-1) 3.2.1.176 pubmed
Irpex lacteus MC-2 BAA76363.1 Q9Y722  
 cellobiohydrolase II (Cel2;Ex-2) 3.2.1.176 pubmed
Irpex lacteus MC-2 BAA76364.1 Q9Y723  
 cellobiohydrolase (GH7B;LqCel7B) (Cel7B) 3.2.1.176 pubmed
Limnoria quadripunctata ADB85438.1 D4HRL0 4GWA[A,B]
4HAP[A,B]
4HAQ[A,B]
4IPM[A]
 cellobiohydrolase (Gh7;MaCel7B) (Cel7B) 3.2.1.176 doi
Melanocarpus albomyces CBS 638.94 CAD56667.1
AAU96164.1
CAD79785.1
CDF76454.1
Q8J0K6 2RFW[A,B,C,D]
2RFY[A,B,C,D]
2RFZ[A,B,C,D]
2RG0[A,B,C,D]
 cellobiohydrolase / cellulase I 3.2.1.176 pubmed
Mycothermus thermophilus CBS 619.91 CAD79780.1    
 cellobiohydrolase I (Cbh-1) 3.2.1.176 pubmed
Neurospora crassa 74-OR23-1A CAA02835.1
CAA54815.1
P38676  
 cellobiohydrolase (Cbh-1;CBH1;NCU07340) 3.2.1.176 doi
Neurospora crassa OR74A EAA33262.1
XP_327626.1
Q7SA23  
 cellobiohydrolase I (Cbh1;CbhI;PcCel7A) (Cel7A) 3.2.1.176 pubmed
Penicillium canescens F-178 / RN3-11-7 AIL95870.1 A0A088DLG0  
 cellobiohydrolase 1 (CbhI) 3.2.1.176 pubmed
Penicillium chrysogenum FS010 AAV65115.1
AAX84833.1
Q5S1P9  
 cellobiohydrolase (Cbh1;CBHI;CBH Ib) (Cel7A) 3.2.1.176 pubmed
Penicillium decumbens 114-2 ACV95805.1 C9EI49  
 endoglucanase I / 7B (Eg1;Egl1) (Cel7B) 3.2.1.4 pubmed
Penicillium decumbens 114-2 / JU-A10 ABY56790.1 B0FMT4  
 cellobiohydrolase I (Cbh1) 3.2.1.176 pubmed
Penicillium janthinellum Biourge IMET 43733 (C41) CAA41780.1 Q06886  
 cellobiohydrolase I (Cbh1) 3.2.1.176 doi
Penicillium occitanis (nom. inval.) Pol6 AAT99321.1 Q68HC2  
 cellobiohydrolase I-1 (Cbh1;CBH62;PcCel7C) (Cel7C) 3.2.1.176 pubmed
Phanerochaete chrysosporium CAA80253.1
AAB46373.1
P13860  
 cellobiohydrolase I-2 (CBH58;CbhI.2;CbhI-4;PcCel7D) (Cel7D) 3.2.1.176 pubmed
Phanerochaete chrysosporium CAA82761.1
AAA19802.1
CAA77789.1
CAA77795.1
CAA80252.1
CAA82762.1
Q09431
Q7LHI2
Q7LHI7
Q7LHI8
Q7LIJ0
1GPI[A]
1H46[X]
1Z3T[A]
1Z3V[A]
1Z3W[A]
 cellulase (CelG5) 3.2.1.4 pubmed
Phialophora sp. G5 / CGMCC3328 ADZ44605.1 H6TBN1  
 endoglucanase 3 (PgEG3) 3.2.1.4 pubmed
Pseudotrichonympha grassii BAB64562.1 Q95YH3  
 endoglucanase 2 (PgEG2) 3.2.1.4 pubmed
Pseudotrichonympha grassii BAB64561.1 Q95YH4  
 endoglucanase 1 (PgEG1h) 3.2.1.4 pubmed
Pseudotrichonympha grassii BAB64553.1
BAB64554.1
BAB64555.1
BAB64556.1
BAB64557.1
BAB64558.1
BAB64559.1
BAB64560.1
Q95NK6
Q95P32
 
 cellobiohydrolase (MG10712.4) (Cel7A) 3.2.1.176 pubmed
Pyricularia oryzae 70-15 XP_367082.1 G4NIA4  
 endo-β-1,3/1,4-glucanase / endotransglucosylase (Egl1;ETG;MoCel7B;MGG_02532;MG02532.4) (Cel7B) 3.2.1.4 pubmed
Pyricularia oryzae 70-15 XP_003721274.1
AEX97159.1
XP_366456.1
XP_366456.2
G4NK46
H2DQS1
 
 cellobiohydrolase 1 (Cbh1A;CBH IB;TeCbh1;ReCel7A) (Cel7A) 3.2.1.176 pubmed
Rasamsonia emersonii IMI 392299 AAL89553.1
AAL33603.2
Q8TFL9 1Q9H[A]
3PFJ[A]
3PFX[A]
3PFZ[A]
3PL3[A]
 cellulase (GHF7-3) 3.2.1.176
3.2.1.4
pubmed
pubmed
Reticulitermes flavipes AGT15838.1 X2CP22  
 cellulase (GHF7-5) 3.2.1.4 pubmed
Reticulitermes flavipes AGT15839.1 X2CHW9  
 cellulase (GHF7-6) 3.2.1.176 pubmed
Reticulitermes flavipes AGT15840.1 X2CNU0  
 cellobiohydrolase I / 7A (TCE0_004r00180) (Cel7A) 3.2.1.176 pubmed
Talaromyces cellulolyticus Y-94 GAM33347.1 A0A0B8MXF6  
 endo-β-1,4-glucanase 7B (TCE0_024r07350) (Cel7B) 3.2.1.4 pubmed
Talaromyces cellulolyticus Y-94 GAM37432.1 A0A6V8H7V0  
 cellobiohydrolase (XynA) 3.2.1.176 pubmed
Talaromyces funiculosus IMI 378536 CAC85737.1
AAP60302.1
CAC07539.1
Q8WZJ4  
 cellobiohydrolase (Cel7A) 3.2.1.176 pubmed
Thermoascus aurantiacus ALKO4242 CAM98447.1
CAD79781.1
A7WNU2  
 cellobiohydrolase (Cbh1;TaCel7A) (Cel7A) 3.2.1.176 pubmed
Thermoascus aurantiacus IFO 9748 AAL83303.1
AAL16941.1
Q8TG37
Q96UR5
 
 cellobiohydrolase (Cel7A) 3.2.1.176 doi
Thermocarpiscus australiensis CAD79782.1    
 cellobiohydrolase (Cbh1;CtCbh1) (Cel7A) 3.2.1.176 pubmed
Thermochaetoides thermophila ALKO4265 CAM98448.1 A7WNU1  
 cellobiohydrolase (Cbh1;EG7-1) (Cel7A) 3.2.1.176 pubmed
Thermochaetoides thermophila CT2 AAW64926.1
AGY80096.1
Q5G2D5
V9PD24
 
 cellobiohydrolase (Cbh3) 3.2.1.176 pubmed
Thermochaetoides thermophila CT2 AAY89412.2
ABN13116.1
A3F8V2
Q4JI68
 
 endo-β-1,4-glucanase (Eg7a;MtEG7a;MYCTH_111372) 3.2.1.4 pubmed
Thermothelomyces thermophilus ATCC 42464 AEO58196.1 G2QCS4  
 cellobiohydrolase (THITE_118360; Cel7A; Tt7A) (Cel7A) 3.2.1.176 doi
Thermothielavioides terrestris NRRL 8126 AEO67172.1 G2QZD9  
 endo-β-1,4-glucanase I (ThCel7B) (Cel7B) 3.2.1.4 pubmed
Trichoderma harzianum CBS 226.95 PTB50088.1   5W0A[A,B]
 cellobiohydrolase I (Cbh1;ThCBHI;ThCel7A) (Cel7A) 3.2.1.176 pubmed
Trichoderma harzianum FP 108 / IOC-3844 AAF36391.1 Q9P8P3 2Y9L[A]
2Y9N[A]
2YOK[A]
 cellobiohydrolase (Cbh1) (Cel7A) 3.2.1.176 pubmed
Trichoderma koningii G-39 CAA49596.1 P00725
P62695
 
 endo-β-1,4-glucanase I (Egl1;EglI;TlCel7A;eCEL;E-CELTR) (Cel7A) 3.2.1.4 pubmed
Trichoderma longibrachiatum CECT 2606 CAA43059.1
1920181A
Q12714  
 endoglucanase I (HpCel7B) (Cel7B) 3.2.1.4 doi
Trichoderma pseudokoningii ABM90986.1 A2TDD6  
 cellobiohydrolase I / chitosanase (CBHI;Cbh1;CBH-I;TrCel7A;HjCel7A;TreCel7A) (Cel7A) 3.2.1.176
3.2.1.132
pubmed
doi
Trichoderma reesei CAH10320.1
AAE25072.1
AAR60512.1
CAF32516.1
CAF32517.1
CAF32518.1
CAR96030.1
G0RVK1
P62694
1CEL[A,B]
1DY4[A]
1EGN[A]
1Q2B[A]
1Q2E[A,B]
2CEL[A,B]
2V3I[A]
2V3R[A]
3CEL[A]
4C4C[A]
4C4D[A]
4CEL[A,B]
4D5I[A]
4D5J[A]
4D5O[A]
4D5P[A]
4D5Q[A]
4D5V[A]
4P1H[A]
4P1J[A]
4UWT[A]
4V0Z[A]
5CEL[A]
5OA5[A,B]
5TC9[A]
6CEL[A]
6GRN[A]
7CEL[A]
7NYT[A]
7OC8[A]
8CEL[nd]
 endo-β-1,4-glucanase I (EGI;Egl1;EG-I;TrCel7B) (Cel7B) 3.2.1.4 pubmed
Trichoderma reesei AAA34212.1
AAE25071.1
AAQ24882.1
AAR60514.1
ABE22093.1
CAR96034.1
CAR96035.1
P07981 1EG1[A,C]
 cellobiohydrolase (cel7A;TRIREDRAFT_123989) 3.2.1.176 pubmed
Trichoderma reesei QM6a EGR44817.1 G0RVK1 6RWF[A]
 cellobiohydrolase I (Cbh1) 3.2.1.176 doi
Trichoderma virens UKM-1 ACF93800.1 B5ATG1  
 cellobiohydrolase I / chitosanase (CBH1) 3.2.1.176
3.2.1.132
doi
doi
Trichoderma viride CAA37878.1 P19355  
 endo-β-1,4-glucanase I (EGI;BglI) 3.2.1.4 pubmed
Trichoderma viride AS 3.3711 AAQ21382.1 Q7Z7X3  
 cellobiohydrolase I (CbhI) 3.2.1.176 pubmed
Trichoderma viride AS 3.3711 AAQ76092.1 Q6UJY1  
 endoglucanase I 3.2.1.4 pubmed
Trichoderma viride HK-75   Q7M4V4  
 cellobiohydrolase I (Cbh1) 3.2.1.176 pubmed
Trichoderma viride MC300-1 BAA36215.1 P19355  
 SM2632A27;SM2632B65 3.2.1.4 pubmed
uncultured symbiotic protist of Neotermes koshunensis BAF57375.1
BAF57379.1
A4UWW5
A4UWW9
 
 SM2637A29 3.2.1.4 pubmed
uncultured symbiotic protist of Neotermes koshunensis BAF57395.1 A4UWY5  
 endo-β-1,4-glucanase (RsSymEG1;RsSym EG I;RsSymEG;SM2038B11) 3.2.1.4 pubmed
uncultured symbiotic protist of Reticulitermes speratus BAF57296.1 A4UWN6  
 SM2039A92 3.2.1.4 pubmed
uncultured symbiotic protist of Reticulitermes speratus BAF57303.1 A4UWP3  
 SM2040A65 3.2.1.4 pubmed
uncultured symbiotic protist of Reticulitermes speratus BAF57305.1 A4UWP5  
 SM2042B24 3.2.1.4 pubmed
uncultured symbiotic protist of Reticulitermes speratus BAF57315.1 A4UWQ5  
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