Glycoside Hydrolase Family 7

Known Activitiesendo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism Retaining
ClanGH-B
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resourcesCAZypedia; HOMSTRAD; InterPro; PFAM; PRINTS;
Statistics GenBank accession (10352); Uniprot accession (521); PDB accession (41); 3D entries (9); cryst (1)
All (4925) Eukaryota (4920) unclassified (5) Structure (9 - 1 cryst) Characterized (73)
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 cellulase III-A (peptide fragment) 3.2.1.4 Acremonium cellulolyticus      
 cellobiohydrolase (Cel7A) 3.2.1.176 Acremonium thermophilum ALKO4245 CAM98445.1 A7WNT9  
 cellobiohydrolase (Cel7B) 3.2.1.176 Acremonium thermophilum ALKO4245 CAM98446.1 A7WNU0  
 cellobiohydrolase (CBH) (peptide fragments) 3.2.1.176 Agaricus arvensis KMJ623,      
 cellobiohydrolase I / chitosanase (CBHI) 3.2.1.132
3.2.1.176
Aspergillus aculeatus F-50 BAA25183.1 O59843.1  
 cellobiohydrolase (CbhB;AN0494.2) 3.2.1.176 Aspergillus nidulans FGSC A4 EAA66593.1    
 endo-β-1,4-glucanase (EglB;AN3418.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA63386.1 C8VHK3  
 cellobiohydrolase B (CbhB;An01g11660) 3.2.1.176 Aspergillus niger CBS 513.88 AAF04492.1
AAP66264.1
CAK44068.1
Q9UVS8  
 cellobiohydrolase A (CbhA;An07g09330) 3.2.1.176 Aspergillus niger CBS 513.88 AAF04491.1
AAP66263.1
AAR79028.1
CAK39699.1
Q9UVS9  
 endo-β-1,4-glucanase (CelB) 3.2.1.4 Aspergillus oryzae KBN616 BAA22589.1 O13455
Q2TX26
 
 endo-β-1,4-glucanase (CelB;AO090010000314) 3.2.1.4 Aspergillus oryzae RIB40 AEB00821.1
BAE66197.1
   
 endo-β-1,3-1,4-glucanase (Bgl7A) 3.2.1.4
3.2.1.73
Bispora sp. MEY-1 / CGMCC 2500 ACT53749.1 D2DRB6  
 cellobiohydrolase (Cel7A) 3.2.1.176 Chaetomium thermophilum ALKO4265 CAM98448.1 A7WNU1  
 cellobiohydrolase (Cbh1) (Cel7A) 3.2.1.176 Chaetomium thermophilum CT2 AAW64926.1 Q5G2D5  
 cellobiohydrolase (Cbh3) 3.2.1.176 Chaetomium thermophilum CT2 AAY89412.2
ABN13116.1
Q4JI68  
 cellobiohydrolase Ia (Cbh1a;CBH Ia) (Cel7A) 3.2.1.176 Chrysosporium lucknowense AAQ38146.1
ACH15004.1
ACH15013.1
   
 cellobiohydrolase (CBH Ib) (peptide fragments) (Cel7B) 3.2.1.176 Chrysosporium lucknowense      
 cellobiohydrolase I (Cel1) 3.2.1.176 Claviceps purpurea T5 CAA68840.1 O00082  
 cellobiohydrolase I (Cel1) 3.2.1.176 Cochliobolus carbonum AAC49089.1 Q00328  
 endo-β-1,4-glucanase (CLhgEG1) 3.2.1.4 Coptotermes lacteus symbiont WH2002 BAC07551.1 Q8MXY2  
 endo-β-1,4-glucanase (CLhgEG2) 3.2.1.4 Coptotermes lacteus symbiont WH2002 BAC07552.1 Q8MXY1  
 cellobiohydrolase (CbhB) 3.2.1.176 Emericella nidulans AAM54070.1 Q8NK02  
 endo-β-1,4-glucanase (EglB) 3.2.1.4 Emericella nidulans AAM54071.1 Q5B7R2
Q8NK01
 
 endo-β-1,4-glucanase I (EG I;Eg1;Fof7) (Cel7B) 3.2.1.4 Fusarium oxysporum AAA65586.1
AAE25069.1
AAG09047.1
P46237 1OVW[A,B,C,D]
2OVW[A,B,C,D]
3OVW[A,B]
4OVW[A,B]
 cellobiohydrolase I (CbhI) 3.2.1.176 Fusicoccum sp. BCC4124 ABS82449.1 A7LN91  
 endoglucanase 3 (HmEG3) (fragment) 3.2.1.4 Holomastigotoides mirabile BAB64565.1 Q95P29  
 endoglucanase 2 (HmEG2) 3.2.1.4 Holomastigotoides mirabile BAB64564.1 Q95P30  
 endoglucanase 1 (HmEG1) 3.2.1.4 Holomastigotoides mirabile BAB64563.1 Q95P31  
 cellobiohydrolase I (Cbh1.1;Cbh1;Cbh-1) (Cel7A) 3.2.1.176 Humicola grisea var. thermoidea CAA35159.1 P15828.2  
 endo-β-1,4-glucanase I (Egl1;EG-I) 3.2.1.4 Humicola grisea var. thermoidea BAA09786.1 Q12622  
 cellobiohydrolase I.2 (Cbh1.2) 3.2.1.176 Humicola grisea var. thermoidea AAD11942.1
AAD31545.1
AAN19007.1
O94093
Q7LV60
 
 cellobiohydrolase I (Exo1) 3.2.1.176 Humicola grisea var. thermoidea IFO9854 BAA74517.1 O93780  
 cellobiohydrolase (Cbh-1) 3.2.1.176 Humicola grisea var. thermoidea IFO9854 BAA09785.1 Q12621  
 cellobiohydrolase (CBH-I;Hi7A) (fragment) (Cel7A) 3.2.1.176 Humicola insolens      
 endoglucanase I (EG I;EG1) (Cel7B) 3.2.1.4 Humicola insolens AAE25068.1
AAE25070.1
P56680 1A39[A]
1DYM[A]
1OJI[A]
1OJJ[A,B]
1OJK[A,B]
2A39[A,B]
 endo-β-1,4-glucanase I (EGI;Egl1;EG-I) (Cel7B) 3.2.1.4 Hypocrea jecorina AAA34212.1
AAE25071.1
AAQ24882.1
AAR60514.1
ABE22093.1
CAR96034.1
CAR96035.1
P07981.1 1EG1[A,C]
 cellobiohydrolase I / chitosanase (CBHI;Cbh1;CBH-I) (Cel7A) 3.2.1.132
3.2.1.176
Hypocrea jecorina L27 AAE25072.1
AAR60512.1
CAF32516.1
CAF32517.1
CAF32518.1
CAH10320.1
CAR96030.1
P62694.1 1CEL[A,B]
1DY4[A]
1EGN[A]
1EK7
1I5M
1Q2B[A]
1Q2E[A,B]
2CEL[A,B]
2V3I[A]
3CEL[A]
4CEL[A,B]
5CEL[A]
6CEL[A]
7CEL[A]
8CEL
 endo-β-1,4-glucanase (Egl1) 3.2.1.4 Hypocrea jecorina PTCC 5142 AAX28897.1 Q5BMS5  
 cellobiohydrolase (Cbh1) (Cel7A) 3.2.1.176 Hypocrea koningii G-39 CAA49596.1 P00725
P62695.1
 
 cellobiohydrolase I (Cbh1;ThCBHI;ThCel7A) (Cel7A) 3.2.1.176 Hypocrea lixii FP 108 / IOC-3844 AAF36391.1 Q9P8P3 cryst
 cellobiohydrolase I / chitosanase (CBH1) 3.2.1.132
3.2.1.176
Hypocrea rufa CAA37878.1 P19355.2  
 endo-β-1,4-glucanase I (EGI;BglI) 3.2.1.4 Hypocrea rufa AS 3.3711 AAQ21382.1 Q7Z7X3  
 cellobiohydrolase I (CbhI) 3.2.1.176 Hypocrea rufa AS 3.3711 AAQ76092.1 Q6UJY1  
 endoglucanase I 3.2.1.4 Hypocrea rufa HK-75   Q7M4V4  
 cellobiohydrolase I (Cbh1) 3.2.1.176 Hypocrea rufa MC300-1 BAA36215.1 P19355  
 exo-cellulase (Cel1;Ex-1) 3.2.1.176 Irpex lacteus MC-2 BAA76363.1 Q9Y722  
 cellobiohydrolase II (Cel2;Ex-2) 3.2.1.176 Irpex lacteus MC-2 BAA76364.1 Q9Y723  
 cellobiohydrolase (MG10712.4) (Cel7A) 3.2.1.176 Magnaporthe grisea 70-15 XP_367082.1    
 cellobiohydrolase (Cel7B) 3.2.1.176 Melanocarpus albomyces AAU96164.1
CAD56667.1
CAD79785.1
Q8J0K6 2RFW[A,B,C,D]
2RFY[A,B,C,D]
2RFZ[A,B,C,D]
2RG0[A,B,C,D]
 cellobiohydrolase (Cbh-1;CBH1;GH6-2;NCU07340) 3.2.1.176 Neurospora crassa OR74A EAA33262.1
XP_327626.1
   
 cellobiohydrolase 1 (CbhI) 3.2.1.176 Penicillium chrysogenum FS010 AAV65115.1
AAX84833.1
Q5S1P9  
 endoglucanase I (Egl1) (Cel7B) 3.2.1.4 Penicillium decumbens 114-2 ABY56790.1 B0FMT4  
 xylanase / cellobiohydrolase (XynA) 3.2.1.176
3.2.1.8
Penicillium funiculosum AAP60302.1
CAC07539.1
CAC85737.1
Q8WZJ4  
 cellobiohydrolase I (Cbh1) 3.2.1.176 Penicillium janthinellum Biourge IMET 43733 (C41) CAA41780.1 Q06886  
 cellobiohydrolase I (Cbh1) 3.2.1.176 Penicillium occitanis Pol6 AAT99321.1 Q68HC2  
 cellobiohydrolase (CBH) (fragment) 3.2.1.176 Penicillium purpurogenum KJS506      
 endo-β-1,4-glucanase (EGI) (peptide fragments) (Cel7B) 3.2.1.4 Penicillium verruculosum      
 cellobiohydrolase I-1 (Cbh1) (Cel7C) 3.2.1.176 Phanerochaete chrysosporium AAB46373.1
CAA80253.1
P13860.1  
 cellobiohydrolase I-2 (Cbh58;CbhI.2;CbhI-4) (Cel7D) 3.2.1.176 Phanerochaete chrysosporium AAA19802.1
CAA77789.1
CAA77795.1
CAA80252.1
CAA82761.1
CAA82762.1
Q09431
Q7LHI2
1GPI[A]
1H46[X]
1Z3T[A]
1Z3V[A]
1Z3W[A]
 cellobiohydrolase (Cbh1-1) (Cel7A) 3.2.1.176 Phanerochaete chrysosporium BKM-1767 AAA09708.1
CAA38274.1
Q01762  
 endoglucanase 3 (PgEG3) 3.2.1.4 Pseudotrichonympha grassii BAB64562.1 Q95YH3  
 endoglucanase 2 (PgEG2) 3.2.1.4 Pseudotrichonympha grassii BAB64561.1 Q95YH4  
 endoglucanase 1 (PgEG1h) 3.2.1.4 Pseudotrichonympha grassii BAB64553.1
BAB64554.1
BAB64555.1
BAB64556.1
BAB64557.1
BAB64558.1
BAB64559.1
BAB64560.1
Q95NK6
Q95P32
 
 cellobiohydrolase (CbhI) 3.2.1.176 Schizochytrium aggregatum      
 cellobiohydrolase 1 (Cbh1A;CBH IB) (Cel7A) 3.2.1.176 Talaromyces emersonii IMI 392299 AAL33603.2
AAL89553.1
Q8TFL9 1Q9H[A]
3PFJ[A]
3PFX[A]
3PFZ[A]
3PL3[A]
 cellobiohydrolase (Cel7A) 3.2.1.176 Thermoascus aurantiacus ALKO4242 CAD79781.1
CAM98447.1
A7WNU2  
 cellobiohydrolase (Cbh1) (Cel7A) 3.2.1.176 Thermoascus aurantiacus IFO 9748 AAL16941.1
AAL83303.1
Q8TG37
Q96UR5
 
 cellobiohydrolase (Cel7A) 3.2.1.176 Thielavia australiensis CAD79782.1    
 cellobiohydrolase (Cel7A) 3.2.1.176 Trametes versicolor 52P      
 endo-β-1,4-glucanase I (Egl1;EglI;TlCel7A) (Cel7A) 3.2.1.4 Trichoderma longibrachiatum CECT 2606 1920181A
CAA43059.1
Q12714  
 endo-β-1,4-glucanase (RsSymEG1;SM2038B11) 3.2.1.4 uncultured symbiotic protist of Reticulitermes speratus BAF57296.1 A4UWN6  
 cellobiohydrolase I (CbhI) (frameshift) 3.2.1.91 Volvariella volvacea V14 AAD41096.1 Q9Y895  
unclassified
Protein Name EC#OrganismGenBankUniprotPDB/3D
 cellobiohydrolase (Cel7) (fragment) 3.2.1.176 unidentified      

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2012-01-31 © Copyright 1998-2012
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