Glycoside Hydrolase Family 79

Activities in Familyβ-glucuronidase (EC 3.2.1.31); hyaluronoglucuronidase (EC 3.2.1.36); heparanase (EC 3.2.1.166); baicalin β-glucuronidase (EC 3.2.1.167); β-4-O-methyl-glucuronidase (EC 3.2.1.-); glycyrrhizin β-glucuronidase (EC 3.2.1.128)
Mechanism Retaining (inferred)
ClanGH-A
3D Structure Status( β / α ) 8 (inferred)
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorGlu (inferred)
External resourcesCAZypedia;
Statistics GenBank accession (1014); Uniprot accession (21); PDB accession (21); 3D entries (5); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-glucuronidase (ACP_2665;AcGlcA79A) (GlcA79A) 3.2.1.31 pubmed
Acidobacterium capsulatum ATCC 51196 ACO32043.1 C1F2K5 3VNY[A]
3VNZ[A]
3VO0[A]
5G0M[A]
5G0Q[A]
5L77[A]
 heparanase / endo-β-glucuronidase (BpHep;DP46_278) 3.2.1.166 pubmed
Burkholderia pseudomallei BEK AIO87434.1 Q63T97 5BWI[A,B]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-glucuronidase (GUS2;AtGus2;At5g07830) 3.2.1.31 pubmed
Arabidopsis thaliana BAB09947.1
AAU05468.1
AAU93572.1
AED91209.1
CAB62595.1
NP_196400.2
A0A654FZP1
Q9FF10
Q9SDA1
 
 β-glucuronidase / β-4-O-methyl-glucuronidase (AnGlcAase;An02g11890) 3.2.1.-
3.2.1.31
pubmed
pubmed
Aspergillus niger CBS 513.88 CAK96418.1 A2QEQ6  
 heparanase 1 (Hpse1;Hpse;CH211-85E10.3-001) 3.2.1.166 pubmed
Danio rerio CAK05012.1
AAI39575.1
NP_001038470.1
A4QNY9
Q1LVP9
 
 4-O-α-L-rhamnosyl-β-D-glucuronidase (FobglcA) 3.2.1.31 pubmed
Fusarium oxysporum 12S BCB92231.1 A0A7I8AV45 7DFQ[A]
7DFS[A]
 heparanase 3.2.1.166 pubmed
Gallus gallus AAK82648.1
AAS29152.1
Q90YK5  
 hyaluronidase (LHyal) 3.2.1.36 pubmed
Hirudo nipponia AHV78514.1 X4Y2L4 7EYO[A]
 heparanase (endo-β-glucuronidase) (Hpa1Hpr1;HEP;HPA;HPSE1;HSE1;hHep;Hs.44227) 3.2.1.166 pubmed
Homo sapiens AAD45669.1
AAD41342.1
AAD45379.1
AAD54516.1
AAD54941.1
AAE32409.1
AAE58088.1
AAE73533.1
AAE73534.1
AAH51321.1
AAN25813.1
AAN93460.1
AAN97232.1
AAP02795.1
AAQ27145.1
AAS22726.1
AAS22727.1
AAS29151.1
AAS29153.1
AAT15085.1
AAW00328.1
AAW04303.1
AAW04304.1
AAW06749.1
AAX47106.1
ABA68377.1
ABC06425.1
ABC06426.1
ABE17595.1
ABH84630.1
ABI07172.1
ABJ35310.1
ACQ12348.1
ACT98237.1
ACT98238.1
BAD96706.1
BAG52128.1
CAC10139.1
CAC10140.1
CAC39726.1
CAC41180.1
CAH05691.1
CAH05692.1
CAH05695.1
CAH05696.1
CAI40110.1
CAI40111.1
CAI72097.1
CAL14864.1
CAL14865.1
CAL91960.1
NP_006656.1
B3KQR6
Q9UL39
Q9Y251
5E8M[A]
5E97[A]
5E98[A]
5E9B[A]
5E9C[A]
5L9Y[A]
5L9Z[A]
5LA4[A]
5LA7[A]
6ZDM[AAA]
7RG8[A]
 heparanase (Hpa;HpsE) 3.2.1.166 pubmed
Mus musculus AAL76083.1
AAE73535.1
AAN41636.1
AAQ15188.1
AAS22728.1
AAS29149.1
AAW04306.1
ABC06428.1
BAC30600.1
BAE32725.1
CAC10141.1
NP_690016.1
B2RS99
Q6YGZ1
 
 β-glucuronidase (Nc6GAL;NCU00937.1) 3.2.1.31 pubmed
Neurospora crassa OR74A BAF75800.1
XP_964763.1
A7M6H1
Q7SFB0
 
 heparanase (HpsE;Hep) 3.2.1.166 pubmed
Rattus norvegicus AAF04563.1
AAE73536.1
AAQ15189.1
AAS29150.1
CAC10143.1
NP_072127.1
Q71RP1
Q9QZF8
 
 baicalin β-glucuronidase (SguS) 3.2.1.167 pubmed
Scutellaria baicalensis BAA97804.1 Q9LRC8  
 glycyrrhizin β-glucuronidase (TpGUS79A) 3.2.1.128 pubmed
Talaromyces pinophilus Li-93 AQW38601.1    
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