Glycoside Hydrolase Family 79

Activities in Familyβ-glucuronidase (EC 3.2.1.31); hyaluronoglucuronidase (EC 3.2.1.36); heparanase (EC 3.2.1.166); baicalin β-glucuronidase (EC 3.2.1.167); β-4-O-methyl-glucuronidase (EC 3.2.1.-)
Mechanism Retaining (inferred)
ClanGH-A
3D Structure Status( β / α ) 8 (inferred)
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorGlu (inferred)
External resourcesCAZypedia;
Statistics GenBank accession (525); Uniprot accession (91); PDB accession (16); 3D entries (3); cryst (0)
All (315) Bacteria (175) Eukaryota (140) Structure (3) Characterized (17)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucuronidase (ACP_2665;AcGlcA79A) (GlcA79A) 3.2.1.31 Acidobacterium capsulatum ATCC 51196 ACO32043.1 C1F2K5 3VNY[A]
3VNZ[A]
3VO0[A]
5G0M[A]
5G0Q[A]
5L77[A]
 heparanase / endo-β-glucuronidase (BpHep;DP46_278) 3.2.1.166 Burkholderia pseudomallei BEK AIO87434.1   5BWI[A,B]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucuronidase (GUS2;AtGus2;At5g07830) 3.2.1.31 Arabidopsis thaliana BAB09947.1
AAU05468.1
AAU93572.1
AED91209.1
CAB62595.1
NP_196400.2
Q9FF10
Q9SDA1
 
 β-glucuronidase / β-4-O-methyl-glucuronidase (AnGlcAase;An02g11890) 3.2.1.-
3.2.1.31
Aspergillus niger CBS 513.88 CAK96418.1 A2QEQ6  
 heparanase (HpsE) 3.2.1.166 Bos taurus AAF87301.2
NP_776507.1
Q9MYY0  
 heparanase 1 (Hpse1;Hpse;CH211-85E10.3-001) 3.2.1.166 Danio rerio CAK05012.1
AAI39575.1
NP_001038470.1
Q1LVP9  
 heparanase 3.2.1.166 Gallus gallus AAK82648.1
AAS29152.1
Q90YK5  
 hyaluronidase 3.2.1.36 Hirudinaria manillensis ABH83946.1    
 hyaluronidase 3.2.1.36 Hirudinaria manillensis CAC22595.1
ABH83949.1
   
 hyaluronidase 3.2.1.36 Hirudinaria manillensis CAC22594.1
ABH83948.1
   
 hyaluronidase 3.2.1.36 Hirudinaria manillensis CAC22593.1
ABH83947.1
   
 hyaluronidase (LHyal) 3.2.1.36 Hirudo nipponia AHV78514.1    
 heparanase (endo-β-glucuronidase) (Hpa1Hpr1;HEP;HPA;HPSE1;HSE1;hHep;Hs.44227) 3.2.1.166 Homo sapiens AAD45669.1
AAD41342.1
AAD45379.1
AAD54516.1
AAD54941.1
AAE32409.1
AAE58088.1
AAE73533.1
AAE73534.1
AAH51321.1
AAN25813.1
AAN93460.1
AAN97232.1
AAP02795.1
AAQ27145.1
AAS22726.1
AAS22727.1
AAS29151.1
AAS29153.1
AAT15085.1
AAW00328.1
AAW04303.1
AAW04304.1
AAW06749.1
AAX47106.1
ABA68377.1
ABC06425.1
ABC06426.1
ABE17595.1
ABH84630.1
ABI07172.1
ABJ35310.1
ACQ12348.1
ACT98237.1
ACT98238.1
BAD96706.1
BAG52128.1
CAC10139.1
CAC10140.1
CAC39726.1
CAC41180.1
CAH05691.1
CAH05692.1
CAH05695.1
CAH05696.1
CAI40110.1
CAI40111.1
CAI72097.1
CAL14864.1
CAL14865.1
CAL91960.1
NP_006656.1
Q9UL39
Q9Y251
5E8M[A]
5E97[A]
5E98[A]
5E9B[A]
5E9C[A]
5L9Y[A]
5L9Z[A]
5LA4[A]
5LA7[A]
 heparanase (Hpa;HpsE) 3.2.1.166 Mus musculus AAL76083.1
AAE73535.1
AAN41636.1
AAQ15188.1
AAS22728.1
AAS29149.1
AAW04306.1
ABC06428.1
BAC30600.1
BAE32725.1
CAC10141.1
NP_690016.1
B2RS99
Q6YGZ1
 
 β-glucuronidase (Nc6GAL;NCU00937.1) 3.2.1.31 Neurospora crassa OR74A BAF75800.1
XP_964763.1
   
 heparanase (HpsE;Hep) 3.2.1.166 Rattus norvegicus AAF04563.1
AAE73536.1
AAQ15189.1
AAS29150.1
CAC10143.1
NP_072127.1
Q71RP1
Q9QZF8
 
 baicalin β-glucuronidase (SguS) 3.2.1.167 Scutellaria baicalensis BAA97804.1 Q9LRC8  
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