Activities in Family	β-4-O-methyl-glucuronidase (EC 3.2.1.-); Glycyrrhizin β-glucuronidase (EC 3.2.1.128); Heparanase / endo-β-glucuronidase (EC 3.2.1.166); Baicalin β-glucuronidase (EC 3.2.1.167); β-glucuronidase (EC 3.2.1.31); Hyaluronidase / hyaluronoglucuronidase (EC 3.2.1.36);
Mechanism	Retaining (inferred) e
Clan	GH-A
3D Structure Status	( β / α ) 8 (inferred)
Catalytic Nucleophile/Base	Glu (inferred)
Catalytic Proton Donor	Glu (inferred)
External resources	CAZypedia;
Statistics	GenBank accession (1555); Uniprot accession (23); PDB accession (48); 3D entries (5); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
β-glucuronidase (ACP_2665;AcGlcA79A) (GlcA79A)	3.2.1.31	Acidobacterium capsulatum ATCC 51196	ACO32043.1	C1F2K5	3VNY[A] 1.50 3VNZ[A] β-D-GlcpA 1.80 3VO0[A] α-D-GlcpA2F-(1-4)-GLU β-D-GlcpA2F-(1-1)-<non_carb> 1.90 5G0M[A] 1.80 5G0Q[A] 1.65 5L77[A] 1.24 7PSH[A] 1.24 7PSI[A] 1.25 7PSJ[A] 1.55 7PSK[A] 1.09 8B0D[A] 8B0E[A] 8OGX[A] 2.00 8OHT[A] 8OHU[A] 8OHV[A]
heparanase / endo-β-glucuronidase (BpHep;DP46_278)	3.2.1.166	Burkholderia pseudomallei BEK	AIO87434.1	Q63T97	5BWI[A,B] 1.60 7PR9[A,B] 1.34 7PRB[A,B] 1.31 8OHW[A,B]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
4-O-α-L-rhamnosyl-β-D-glucuronidase (FoBGlcA)	3.2.1.31	Fusarium oxysporum 12S	BCB92231.1	A0A7I8AV45	7DFQ[A] 1.51 7DFS[A] α-L-Rhap-(1-4)-α-D-GlcpA α-L-Rhap-(1-4)-β-D-GlcpA 1.49
hyaluronidase (LHyal)	3.2.1.36	Hirudo nipponia	AHV78514.1	X4Y2L4	7EYO[A] 1.85
heparanase (endo-β-glucuronidase) (Hpa1Hpr1;HEP;HPA;HPSE1;HSE1;hHep;Hs.44227)	3.2.1.166	Homo sapiens	AAD45669.1 AAD41342.1 AAD45379.1 AAD54516.1 AAD54941.1 AAE32409.1 AAE58088.1 AAE73533.1 AAE73534.1 AAH51321.1 AAN25813.1 AAN93460.1 AAN97232.1 AAP02795.1 AAQ27145.1 AAS22726.1 AAS22727.1 AAS29151.1 AAS29153.1 AAT15085.1 AAW00328.1 AAW04303.1 AAW04304.1 AAW06749.1 AAX47106.1 ABA68377.1 ABC06425.1 ABC06426.1 ABE17595.1 ABH84630.1 ABI07172.1 ABJ35310.1 ACQ12348.1 ACT98237.1 ACT98238.1 BAD96706.1 BAG52128.1 CAC10139.1 CAC10140.1 CAC39726.1 CAC41180.1 CAH05691.1 CAH05692.1 CAH05695.1 CAH05696.1 CAI40110.1 CAI40111.1 CAI72097.1 CAL14864.1 CAL14865.1 CAL91960.1 NP_006656.1	B3KQR6 Q9UL39 Q9Y251	5E8M[A] 1.75 5E97[A] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-1)-<non_carb> 1.63 5E98[A] β-D-GlcpA-(1-4)-α-D-GlcpNSO3-(1-4)-β-D-GlcpA-(1-1)-<non_carb> 1.63 5E9B[A] α-D-GlcpNSO3-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNSO36SO3-(1-4)-β-D-GlcpA 1.88 5E9C[A] β-D-4-deoxy-GlcpA2SO3-(1-4)-α-D-GlcpNSO36SO3-(1-4)-α-L-IdopA-(1-4)-β-D-GlcpNSO36SO3 1.73 5L9Y[A] 1.88 5L9Z[A] 1.57 5LA4[A] 1.90 5LA7[A] 1.94 6ZDM[AAA] 7PR7[A] 1.52 7PR8[A] 1.66 7PRT[A] 1.70 7RG8[A] 1.30 7YI7[A] 2.80 7YJC[A] 2.30 8B0B[A] 8B0C[A] 8BAC[A] 8CQI[A] β-D-GlcpNAc 2.10 8E07[A] β-D-Xylp2SO33SO34SO3-(1-4)-β-D-Xylp2SO33SO3-(1-4)-β-D-Xylp2SO33SO3 1.80 8E08[A] β-D-Xylp2SO33SO34SO3-(1-4)-β-D-Xylp2SO33SO3-(1-4)-β-D-Xylp2SO33SO3-(1-4)-β-D-Xylp2SO33SO3 1.93 8JYG[A] 2.00 8OHQ[A] 8OHR[A]
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