Glycoside Hydrolase Family 79

Activities in Familyβ-glucuronidase (EC 3.2.1.31); hyaluronoglucuronidase (EC 3.2.1.36); heparanase (EC 3.2.1.166); baicalin β-glucuronidase (EC 3.2.1.167); β-4-O-methyl-glucuronidase (EC 3.2.1.-)
Mechanism Retaining (inferred)
ClanGH-A
3D Structure Status( β / α ) 8 (inferred)
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorGlu (inferred)
External resourcesCAZypedia;
Statistics GenBank accession (525); Uniprot accession (91); PDB accession (16); 3D entries (3); cryst (0)
All (315) Bacteria (175) Eukaryota (140) Structure (3) Characterized (17)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-glucuronidase (ACP_2665;AcGlcA79A) (GlcA79A) 3.2.1.31 Acidobacterium capsulatum ATCC 51196 ACO32043.1 C1F2K5
3VNY[A] 1.50
3VNZ[A] β-D-GlcpA
1.80
3VO0[A] α-D-GlcpA2F-(1-4)-GLU
β-D-GlcpA2F-(1-1)-<non_carb>
1.90
5G0M[A] 1.80
5G0Q[A] 1.65
5L77[A] 1.24
 heparanase / endo-β-glucuronidase (BpHep;DP46_278) 3.2.1.166 Burkholderia pseudomallei BEK AIO87434.1  
5BWI[A,B] 1.60
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 heparanase (endo-β-glucuronidase) (Hpa1Hpr1;HEP;HPA;HPSE1;HSE1;hHep;Hs.44227) 3.2.1.166 Homo sapiens AAD45669.1
AAD41342.1
AAD45379.1
AAD54516.1
AAD54941.1
AAE32409.1
AAE58088.1
AAE73533.1
AAE73534.1
AAH51321.1
AAN25813.1
AAN93460.1
AAN97232.1
AAP02795.1
AAQ27145.1
AAS22726.1
AAS22727.1
AAS29151.1
AAS29153.1
AAT15085.1
AAW00328.1
AAW04303.1
AAW04304.1
AAW06749.1
AAX47106.1
ABA68377.1
ABC06425.1
ABC06426.1
ABE17595.1
ABH84630.1
ABI07172.1
ABJ35310.1
ACQ12348.1
ACT98237.1
ACT98238.1
BAD96706.1
BAG52128.1
CAC10139.1
CAC10140.1
CAC39726.1
CAC41180.1
CAH05691.1
CAH05692.1
CAH05695.1
CAH05696.1
CAI40110.1
CAI40111.1
CAI72097.1
CAL14864.1
CAL14865.1
CAL91960.1
NP_006656.1
Q9UL39
Q9Y251
5E8M[A] 1.75
5E97[A] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-1)-<non_carb>
1.63
5E98[A] β-D-GlcpA-(1-4)-α-D-GlcpNSO3-(1-4)-β-D-GlcpA-(1-1)-<non_carb>
1.63
5E9B[A] α-D-GlcpNSO3-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNSO36SO3-(1-4)-β-D-GlcpA
1.88
5E9C[A] β-D-4-deoxy-GlcpA2SO3-(1-4)-α-D-GlcpNSO36SO3-(1-4)-α-L-IdopA-(1-4)-β-D-GlcpNSO36SO3
1.73
5L9Y[A] 1.88
5L9Z[A] 1.57
5LA4[A] 1.90
5LA7[A] 1.94
Top


Last update: 2017-11-06 © Copyright 1998-2017
AFMB - CNRS - Université d'Aix-Marseille