Glycoside Hydrolase Family 79

Activities in Familyβ-glucuronidase (EC 3.2.1.31); hyaluronoglucuronidase (EC 3.2.1.36); heparanase (EC 3.2.1.166); baicalin β-glucuronidase (EC 3.2.1.167); β-4-O-methyl-glucuronidase (EC 3.2.1.-); glycyrrhizin β-glucuronidase (EC 3.2.1.128)
Mechanism Retaining (inferred)
ClanGH-A
3D Structure Status( β / α ) 8 (inferred)
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorGlu (inferred)
External resourcesCAZypedia;
Statistics GenBank accession (1014); Uniprot accession (21); PDB accession (21); 3D entries (5); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-glucuronidase (ACP_2665;AcGlcA79A) (GlcA79A) 3.2.1.31 Acidobacterium capsulatum ATCC 51196 ACO32043.1 C1F2K5
3VNY[A] 1.50
3VNZ[A] β-D-GlcpA
1.80
3VO0[A] α-D-GlcpA2F-(1-4)-GLU
β-D-GlcpA2F-(1-1)-<non_carb>
1.90
5G0M[A] 1.80
5G0Q[A] 1.65
5L77[A] 1.24
 heparanase / endo-β-glucuronidase (BpHep;DP46_278) 3.2.1.166 Burkholderia pseudomallei BEK AIO87434.1 Q63T97
5BWI[A,B] 1.60
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 4-O-α-L-rhamnosyl-β-D-glucuronidase (FobglcA) 3.2.1.31 Fusarium oxysporum 12S BCB92231.1 A0A7I8AV45
7DFQ[A] 1.51
7DFS[A] α-L-Rhap-(1-4)-α-D-GlcpA
α-L-Rhap-(1-4)-β-D-GlcpA
1.49
 hyaluronidase (LHyal) 3.2.1.36 Hirudo nipponia AHV78514.1 X4Y2L4
7EYO[A]
 heparanase (endo-β-glucuronidase) (Hpa1Hpr1;HEP;HPA;HPSE1;HSE1;hHep;Hs.44227) 3.2.1.166 Homo sapiens AAD45669.1
AAD41342.1
AAD45379.1
AAD54516.1
AAD54941.1
AAE32409.1
AAE58088.1
AAE73533.1
AAE73534.1
AAH51321.1
AAN25813.1
AAN93460.1
AAN97232.1
AAP02795.1
AAQ27145.1
AAS22726.1
AAS22727.1
AAS29151.1
AAS29153.1
AAT15085.1
AAW00328.1
AAW04303.1
AAW04304.1
AAW06749.1
AAX47106.1
ABA68377.1
ABC06425.1
ABC06426.1
ABE17595.1
ABH84630.1
ABI07172.1
ABJ35310.1
ACQ12348.1
ACT98237.1
ACT98238.1
BAD96706.1
BAG52128.1
CAC10139.1
CAC10140.1
CAC39726.1
CAC41180.1
CAH05691.1
CAH05692.1
CAH05695.1
CAH05696.1
CAI40110.1
CAI40111.1
CAI72097.1
CAL14864.1
CAL14865.1
CAL91960.1
NP_006656.1
B3KQR6
Q9UL39
Q9Y251
5E8M[A] 1.75
5E97[A] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-1)-<non_carb>
1.63
5E98[A] β-D-GlcpA-(1-4)-α-D-GlcpNSO3-(1-4)-β-D-GlcpA-(1-1)-<non_carb>
1.63
5E9B[A] α-D-GlcpNSO3-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNSO36SO3-(1-4)-β-D-GlcpA
1.88
5E9C[A] β-D-4-deoxy-GlcpA2SO3-(1-4)-α-D-GlcpNSO36SO3-(1-4)-α-L-IdopA-(1-4)-β-D-GlcpNSO36SO3
1.73
5L9Y[A] 1.88
5L9Z[A] 1.57
5LA4[A] 1.90
5LA7[A] 1.94
6ZDM[AAA]
7RG8[A] 1.30
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