Glycoside Hydrolase Family 76

Activities in Familyα-1,6-mannanase (EC 3.2.1.101); α-glucosidase (EC 3.2.1.20)
Mechanism Retaining
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseAsp (inferred from 3-D structure)
Catalytic Proton DonorAsp (inferred from 3-D structure)
External resourcesCAZypedia;
Statistics GenBank accession (3070); Uniprot accession (10); PDB accession (29); 3D entries (8); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-1,6-mannanase (BtGH76-MD40;Btheta7330_05006) 3.2.1.101 Bacteroides thetaiotaomicron 7330 ALJ44520.1 A0A0P0FW82
6U4Z[A] 1.40
 endo-α-1,6-mannanase (BT3782;BT_3782) 3.2.1.101 Bacteroides thetaiotaomicron VPI-5482 AAO78887.1
NP_812693.1
Q8A184
4MU9[A,B] 1.89
 endo-α-1,6-mannanase (BT3792) 3.2.1.101 Bacteroides thetaiotaomicron VPI-5482 AAO78897.1
NP_812703.1
Q8A174
4C1S[A,B] 2.10
 α-mannanase (BT2949)   Bacteroides thetaiotaomicron VPI-5482 AAO78055.1
NP_811861.1
 
4V1R[A,B] 1.80
4V1S[A,B] 1.50
 Lin0763   Listeria innocua Clip11262 CAC95995.1
NP_470105.1
 
3K7X[A] 1.89
 endo-α-1,6-mannanase (Aman6) 3.2.1.101 Niallia circulans TN31 / TN-31 BAA75632.1 Q9Z4P9
4BOJ[A,B,C] α-D-Manp-(1-6)-α-D-Manp
1.38
4BOK[A] 2.05
4D4A[A,B] 1.40
4D4B[A,B] α-D-Manp-(1-6)-α-D-Manp1SH6SH-(1-1)-methyl
1.30
4D4C[A,B] α-D-Manp-(1-1)-<non_carb>
<carb_like_DMJ>
1.30
4D4D[A,B] α-D-Manp-(1-1)-<non_carb>
<carb_like_IFM>
1.40
5AGD[A,B] α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp
1.20
5M77[A,B] α-D-Manp-(1-6)-α-D-Manp6SH-(1-1)-<non_carb>
1.46
5N0F[A,B] α-D-Manp-(1-1)-<non_carb>
1.69
6ZBM[A] 1.47
6ZBW[A] 1.40
6ZBX[A] 1.35
7NL5[A] α-D-Manp-(1-6)-α-D-Manp-(1-1)-<non_carb>
1.40
 ORF   Salegentibacter sp. Hel_I_6    
6SHD[B,C] 2.00
6SHM[A] α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp
1.90
6Y8F[A] α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp
1.47
6SHD[A] 2.00
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 CTHT_0020800   Chaetomium thermophilum var. thermophilum DSM 1495 XP_006692554.1  
6RY0[A] 1.05
6RY1[A] α-D-Manp
1.30
6RY2[A] α-D-Manp-(1-2)-α-D-Manp
1.30
6RY5[A] α-D-Manp-(1-6)-β-D-Manp
1.30
6RY6[A] α-D-GlcpN
1.30
6RY7[A] β-D-Glcp-(1-3)-β-D-Glcp
1.30
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