Glycoside Hydrolase Family 76

Activities in Family	α-1,6-mannanase (EC 3.2.1.101); α-glucosidase (EC 3.2.1.20)
Mechanism	Retaining a
3D Structure Status	( α / α ) ₆ barrel
Catalytic Nucleophile/Base	Asp (inferred from 3-D structure)
Catalytic Proton Donor	Asp (inferred from 3-D structure)
External resources	CAZypedia;
Statistics	GenBank accession (4318); Uniprot accession (13); PDB accession (28); 3D entries (8); cryst (0)

Summary

Download GH76 (4215) Taxonomic display Structure (8) Characterized (11)


Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-1,6-mannanase (BtGH76-MD40; Btheta7330_05006)	3.2.1.101	pubmed	Bacteroides thetaiotaomicron 7330	ALJ44520.1	A0A0P0FW82	6U4Z[A]
endo-α-1,6-mannanase (BT3782;BT_3782)	3.2.1.101	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78887.1 NP_812693.1	Q8A184	4MU9[A,B]
endo-α-1,6-mannanase (BT2631)	3.2.1.101	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO77738.1 NP_811544.1	Q8A4G8
endo-α-1,6-mannanase (BT2623)	3.2.1.101	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO77730.1 NP_811536.1	Q8A4H6
endo-α-1,6-mannanase (BT3792)	3.2.1.101	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78897.1 NP_812703.1	Q8A174	4C1S[A,B]
endo-α-1,6-mannanase (Aman6)	3.2.1.101	pubmed	Niallia circulans TN31 / TN-31	BAA75632.1	Q9Z4P9	4BOJ[A,B,C] 4BOK[A] 4D4A[A,B] 4D4B[A,B] 4D4C[A,B] 4D4D[A,B] 5AGD[A,B] 5M77[A,B] 5N0F[A,B] 6ZBM[A] 6ZBW[A,B] 6ZBX[A,B] 7NL5[A]
α-1,6-mannanase (ShGH76)	3.2.1.101	pubmed	Salegentibacter sp. Hel_I_6	WP_037317868.1	A0A7M4DUB5 A0A7M4DUB6	6SHD[A,B,C] 6SHM[A] 6Y8F[A]
α-glucosidase activity on pNP-α-D-maltopyranoside (STAUR_0381)	3.2.1.20	pubmed	Stigmatella aurantiaca DW4/3-1	ADO68190.1	Q08R12
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
cell wall [GPI-anchor] α-1,6-mannotransglycosylase / α-1,6-mannanase (Dcw1; GH76-3; NCU08127)	3.2.1.101	pubmed	Neurospora crassa OR74A	EAA30434.1 XP_328833.1	Q7S4K4
cell wall [GPI-anchor] α-1,6-mannotransglycosylase / α-1,6-mannanase (Dfg5; GH76-7; NCU03770)	3.2.1.101	pubmed	Neurospora crassa OR74A	CAC28653.1 EAA31880.1 XP_323071.1	Q1K7A8 Q9C2J1
cell wall [GPI-anchor] α-1,6-mannotransglycosylase / α-1,6-mannanase (Dfg5; CtDfg5; CTHT_0020800)	3.2.1.101	pubmed	Thermochaetoides thermophila DSM 1495	XP_006692554.1	G0S3F2	6RY0[A] 6RY1[A] 6RY2[A] 6RY5[A] 6RY6[A] 6RY7[A]
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