Glycoside Hydrolase Family 63

Activities in Familyprocessing α-glucosidase (EC 3.2.1.106); α-1,3-glucosidase (EC 3.2.1.84); α-glucosidase (EC 3.2.1.20); mannosylglycerate α-mannosidase / mannosylglycerate hydrolase (EC 3.2.1.170)
Mechanism Inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorAsp (inferred)
Statistics GenBank accession (2074); Uniprot accession (205); PDB accession (18); 3D entries (3); cryst (0)
All (1822) Archaea (3) Bacteria (1291) Eukaryota (528) Structure (3) Characterized (19)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-glucosidase (YgjK;EcYgjK;b3080) 3.2.1.20
3.2.1.84
Escherichia coli str. K-12 substr. MG1655 AAA57881.1
AAC76115.1
AIZ89900.1
ALI39220.1
AMC95987.1
NP_417551.1
P42592
2DS3[A,B] 1.78
3C67[A,B] α-D-Glcp
1.90
3C68[A,B] β-D-Manp
1.50
3C69[A,B] β-D-Galp
2.00
3D3I[A,B] 1.78
3W7S[A,B] α-D-Glcp
1.90
3W7T[A,B] β-D-Manp
1.50
3W7U[A,B] α-D-Galp
1.99
3W7W[A,B] α-D-Glcp-(1-2)-α-D-Galp
2.00
3W7X[A,B] α-D-Galp-(1-6)-α-D-Glcp
2.70
5CA3[A,B] α-D-Glcp
β-D-Galp-(1-4)-α-D-Glcp
β-D-Glcp
1.80
5CA4[A,B] β-D-Galp-(1-4)-α-D-Glcp
β-D-Glcp
2.10
5GW7[A,B] β-D-Galp-(1-4)-α-D-Glcp
β-D-Glcp
2.20
 mannosylglycerate hydrolase (Tt8MGH;TTHA0978) 3.2.1.170 Thermus thermophilus HB8 BAD70801.1 Q5SJN0
2Z07[A,B] 2.10
4WVA[A,B] 1.67
4WVB[A,B] α-D-Glcp
1.77
4WVC[A,B] 2.10
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 processing α-1,2-glucosidase I (Cwh41;Cwht1;Gls1;ScCwh41p;YGL027c;Der7) 3.2.1.106 Saccharomyces cerevisiae S288c AAC49157.1
CAA96728.1
NP_011488.1
P53008
4J5T[A] 2.04
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