Activities in Family	Mannosyl-oligosaccharide α-glucosidase (EC 3.2.1.106); Mannosylglycerate α-mannosidase / mannosylglycerate hydrolase (EC 3.2.1.170); α-glucosidase (EC 3.2.1.20); Glucosylglycerate hydrolase (EC 3.2.1.208); Exo-α-1,3-glucanase / α-1,3-glucosidase (EC 3.2.1.84);
Mechanism	Inverting a
Clan	GH-G
3D Structure Status	( α / α ) 6 barrel
Catalytic Nucleophile/Base	Glu (inferred)
Catalytic Proton Donor	Asp (inferred)
External resources	CAZypedia;
Statistics	GenBank accession (6634); Uniprot accession (30); PDB accession (75); 3D entries (6); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-glucosidase (YgjK; EcYgjK; b3080)	3.2.1.20 3.2.1.84	Escherichia coli str. K-12 substr. MG1655	AAA57881.1 AAC76115.1 AIZ89900.1 ALI39220.1 AMC95987.1 AUG17798.1 AVI53253.1 AYG17956.1 NP_417551.1	P42592	2DS3[A,B] 1.78 3C67[A,B] α-D-Glcp 1.90 3C68[A,B] β-D-Manp 1.50 3C69[A,B] β-D-Galp 2.00 3D3I[A,B] 1.78 3W7S[A,B] α-D-Glcp 1.90 3W7T[A,B] β-D-Manp 1.50 3W7U[A,B] α-D-Galp 1.99 3W7W[A,B] α-D-Glcp-(1-2)-α-D-Galp 2.00 3W7X[A,B] α-D-Galp-(1-6)-α-D-Glcp 2.70 5CA3[A,B] α-D-Glcp β-D-Galp-(1-4)-α-D-Glcp β-D-Glcp 1.80 5CA4[A,B] β-D-Galp-(1-4)-α-D-Glcp β-D-Glcp 2.10 5GW7[A,B] β-D-Galp-(1-4)-α-D-Glcp β-D-Glcp 2.20 6XUX[A] 1.90 8AFE[C,D,I,J] 3.30 8AFH[C,D,I,J,M,N,S,T] 3.90 8AFL[C,D] 4.40 8AFM[C,D,I,J] 4.80 8AHL[E,F,K,L] 4.10 8AIA[C,J,K,L] 5.10 8AIX[C,J,K,L,O,V,W,X] 5.80 8AJB[E,F,K,L,Q,R,W,X] 4.30
glucosylglycerate hydrolase (MhGgH; GgH; MHAS_04250)	3.2.1.208	Mycolicibacterium hassiacum DSM 44199	VCT92520.1 WP_005623031.1	A0A3P4A4P2 K5BDL0	5OHC[A,B] 2.00 5OHZ[A,B,C,D] 2.04 5OI0[A,B] 1.68 5OI1[A,B] 1.75 5OIE[A,B] 2.07 5OIV[A,B] 1.78 5OIW[A,B] α-D-Glcp-(1-1)-<non_carb> 1.71 5OJ4[A,B] α-D-Manp-(1-1)-<non_carb> 1.79 5OJU[A,B] α-D-Glcp-(1-1)-<non_carb> 2.17 5OJV[A,B] α-D-Manp-(1-1)-<non_carb> 2.06 5ONT[A,B] α-D-Glcp-(1-1)-<non_carb> 2.05 5ONZ[A,B] α-D-Glcp-(1-1)-<non_carb> 1.93 5OO2[A,B] α-D-Glcp-(1-1)-<non_carb> 2.06 6G3N[A,B] 2.32 6Q5T[A,B] 2.54
mannosylglycerate hydrolase (Tt8MGH;TTHA0978)	3.2.1.170	Thermus thermophilus HB8	BAD70801.1	Q5SJN0	2Z07[A,B] 2.10 4WVA[A,B] 1.67 4WVB[A,B] α-D-Glcp 1.77 4WVC[A,B] 2.10
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-glucosidase I (Gcs1)		Mus musculus	AAD00906.1 AAH51949.1 BAE26149.1 BAE30817.1 BAE30968.1 BAE34029.1 NP_065644.1		5MHF[A,B,C,D] 2.10
processing α-1,2-glucosidase I (Cwh41;Cwht1;Gls1;ScCwh41p;YGL027c;Der7)	3.2.1.106	Saccharomyces cerevisiae S288c	AAC49157.1 CAA96728.1 NP_011488.1	P53008	4J5T[A] 2.04
mannosyl-oligosaccharide α-glucosidase (Ct α-GluI; CTHT_0061620)	3.2.1.106	Thermochaetoides thermophila DSM 1495	EGS18147.1	G0SFD1	7R6J[A,B] 7RD2[A,B] 7REV[A,B] 7T66[A,B] 7T68[A,B] 7T6W[A,B] 7T8V[A,B] 8E3J[A,B] 8E3P[A,B] 8E4I[A,B] 8E4K[A,B] 8E4Z[A,B] 8E5U[A,B] 8E6G[A,B] 8ECW[A,B] 8EGV[A,B] 8EHP[A,B] 8EID[A,B] 8EKN[A,B] 8ELE[A,B] 8EPJ[A,B] 8EPO[A,B] 8EPR[A,B] 8EQ7[A,B] 8EQX[A,B] 8ER4[A,B] 8ETL[A,B] 8ETO[A,B] 8EUD[A,B] 8EUR[A,B] 8EUT[A,B] 8EUX[A,B]
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