Glycoside Hydrolase Family 63

Activities in Familyprocessing α-glucosidase (EC 3.2.1.106); α-1,3-glucosidase (EC 3.2.1.84); α-glucosidase (EC 3.2.1.20); mannosylglycerate α-mannosidase / mannosylglycerate hydrolase (EC 3.2.1.170)
Mechanism Inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorAsp (inferred)
Statistics GenBank accession (2074); Uniprot accession (205); PDB accession (18); 3D entries (3); cryst (0)
All (1822) Archaea (3) Bacteria (1291) Eukaryota (528) Structure (3) Characterized (19)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ECDH10B_3255 3.2.1.20
3.2.1.84
Escherichia coli str. K-12 substr. DH10B ACB04164.1 B1XG84  
 α-glucosidase (YgjK;EcYgjK;b3080) 3.2.1.20
3.2.1.84
Escherichia coli str. K-12 substr. MG1655 AAA57881.1
AAC76115.1
AIZ89900.1
ALI39220.1
AMC95987.1
NP_417551.1
P42592 2DS3[A,B]
3C67[A,B]
3C68[A,B]
3C69[A,B]
3D3I[A,B]
3W7S[A,B]
3W7T[A,B]
3W7U[A,B]
3W7W[A,B]
3W7X[A,B]
5CA3[A,B]
5CA4[A,B]
5GW7[A,B]
 ECK3070:JW3051:b3080 (YgjK) 3.2.1.20
3.2.1.84
Escherichia coli str. K-12 substr. W3110 BAE77130.1
APC53250.1
   
 glucosylglycerate hydrolase (GgH) 3.2.1.- Mycobacterium hassiacum DSM 44199 WP_005623031.1    
 mannosylglycerate hydrolase (RradSPS_2892) 3.2.1.170 Rubrobacter radiotolerans RSPS-4 AFC76324.1
AHY48175.1
   
 mannosylglycerate hydrolase (MgH;TT_C0614) 3.2.1.170 Thermus thermophilus HB27 AAS80962.1 Q72K04  
 mannosylglycerate hydrolase (Tt8MGH;TTHA0978) 3.2.1.170 Thermus thermophilus HB8 BAD70801.1 Q5SJN0 2Z07[A,B]
4WVA[A,B]
4WVB[A,B]
4WVC[A,B]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-1,2-glucosidase / α-glucosidase I (Gcs1;KNF;KNOPF;At1g67490 ) 3.2.1.106 Arabidopsis thaliana NP_176916.2
AAC18786.1
AAG52297.1
AAL17718.1
AEE34653.1
AEE34654.1
BAC43508.1
CAC34725.1
NP_176916.1
F4HTM3
O64796
Q8GWC8
Q940D4
Q9C5B4
Q9CAG7
 
 processing α-glucosidase I 3.2.1.106 Aspergillus brasiliensis ATCC 9642 (formerly Aspergillus niger ATCC 9642) BAK64066.1    
 α-glucosidase I (Cwh41;AfCwh41) 3.2.1.106 Aspergillus fumigatus YJ-407 AAR23808.1 Q6S9W4  
 α-glucosidase I (Agl-1;F13H10.4c) 3.2.1.106 Caenorhabditis elegans Bristol N2 CAN86588.1
CAA92954.1
CAL36499.1
CAL36500.1
A5JYS7
Q19426
 
 α-glucosidase I (Cwh41;CaCWH41) 3.2.1.106 Candida albicans SC5314 ABB97046.1    
 α-glucosidase (processing) (Gcs1) 3.2.1.106 Homo sapiens AAI17253.1
AAH28337.1
AAI17251.1
BAF85242.1
BAF85408.1
CAA60683.1
CAD19636.1
NP_006293.1
A8K938
Q13724
Q13724
 
 α-glucosidase I (Gcs1) 3.2.1.106 Mus musculus AAD00906.1
AAH51949.1
BAE26149.1
BAE30817.1
BAE30968.1
BAE34029.1
NP_065644.1
Q80UM7
Q80UM7
 
 mannosyl-oligosaccharide α-glucosidase (OsMOGS;Os01g0921200;LOC_Os01g69210) 3.2.1.- Oryza sativa Japonica Group EEE55907.1
BAB86175.1
BAF07139.1
BAS75938.1
Q8RZJ2  
 α-glucosidase (processing) 3.2.1.106 Rattus rattus AAC36477.1
NP_113937.1
O88941  
 processing α-1,2-glucosidase I (Cwh41;Cwht1;Gls1;ScCwh41p;YGL027c;Der7) 3.2.1.106 Saccharomyces cerevisiae S288c AAC49157.1
CAA96728.1
NP_011488.1
P53008 4J5T[A]
 mannosylglycerate hydrolase (MgH;SELMODRAFT_437793) 3.2.1.170 Selaginella moellendorffii EFJ37158.1    
 α-glucosidase (Cwh41;SsCWH41;SPSK05967;HMPREF1624_08365) 3.2.1.106 Sporothrix schenckii ATCC 58251 ERS95155.1    
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