Glycoside Hydrolase Family 63

Activities in Familyprocessing α-glucosidase (EC 3.2.1.106); α-1,3-glucosidase (EC 3.2.1.84); α-glucosidase (EC 3.2.1.20); mannosylglycerate α-mannosidase / mannosylglycerate hydrolase (EC 3.2.1.170); glucosylglycerate hydrolase (EC 3.2.1.208)
Mechanism Inverting
ClanGH-G
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorAsp (inferred)
External resourcesCAZypedia;
Statistics GenBank accession (5868); Uniprot accession (30); PDB accession (41); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 α-glucosidase (YgjK;EcYgjK;b3080) 3.2.1.20
3.2.1.84
pubmed
pubmed
Escherichia coli str. K-12 substr. MG1655 AAA57881.1
AAC76115.1
AIZ89900.1
ALI39220.1
AMC95987.1
AUG17798.1
AVI53253.1
AYG17956.1
NP_417551.1
P42592 2DS3[A,B]
3C67[A,B]
3C68[A,B]
3C69[A,B]
3D3I[A,B]
3W7S[A,B]
3W7T[A,B]
3W7U[A,B]
3W7W[A,B]
3W7X[A,B]
5CA3[A,B]
5CA4[A,B]
5GW7[A,B]
6XUX[A]
 glucosylglycerate hydrolase (MhGgH; GgH; MHAS_04250) 3.2.1.208 pubmed
Mycolicibacterium hassiacum DSM 44199 VCT92520.1
WP_005623031.1
A0A3P4A4P2
K5BDL0
5OHC[A,B]
5OHZ[A,B,C,D]
5OI0[A,B]
5OI1[A,B]
5OIE[A,B]
5OIV[A,B]
5OIW[A,B]
5OJ4[A,B]
5OJU[A,B]
5OJV[A,B]
5ONT[A,B]
5ONZ[A,B]
5OO2[A,B]
6G3N[A,B]
6Q5T[A,B]
 mannosylglycerate hydrolase (RradSPS_2892) 3.2.1.170 pubmed
Rubrobacter radiotolerans RSPS-4 AFC76324.1
AHY48175.1
J9PY59  
 mannosylglycerate hydrolase (MgH;TT_C0614) 3.2.1.170 pubmed
Thermus thermophilus HB27 AAS80962.1 Q72K04  
 mannosylglycerate hydrolase (Tt8MGH;TTHA0978) 3.2.1.170 pubmed
Thermus thermophilus HB8 BAD70801.1 Q5SJN0 2Z07[A,B]
4WVA[A,B]
4WVB[A,B]
4WVC[A,B]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 α-1,2-glucosidase / α-glucosidase I (Gcs1;KNF;KNOPF;At1g67490 ) 3.2.1.106 pubmed
Arabidopsis thaliana NP_176916.2
AAC18786.1
AAG52297.1
AAL17718.1
AEE34653.1
AEE34654.1
BAC43508.1
CAC34725.1
NP_176916.1
F4HTM3
O64796
Q8GWC8
Q940D4
Q9C5B4
Q9CAG7
 
 processing α-glucosidase I 3.2.1.106 pubmed
Aspergillus brasiliensis ATCC 9642 (formerly Aspergillus niger ATCC 9642) BAK64066.1 G1UJA9  
 α-glucosidase I (Agl-1;F13H10.4c) 3.2.1.106 pubmed
Caenorhabditis elegans Bristol N2 CAN86588.1
CAA92954.1
CAL36499.1
CAL36500.1
A5JYS7
Q19426
 
 α-glucosidase I (Cwh41;CaCWH41) 3.2.1.106 pubmed
Candida albicans SC5314 ABB97046.1 Q2V621  
 α-glucosidase (processing) (Gcs1) 3.2.1.106 pubmed
Homo sapiens AAI17253.1
AAH28337.1
AAI17251.1
ADO22282.1
BAF85242.1
BAF85408.1
CAA60683.1
CAD19636.1
NP_006293.1
A0A384MDR6
A8K938
A8K9K4
Q13724
Q13724
Q58F09
 
 mannosyl-oligosaccharide α-glucosidase (OsMOGS;Os01g0921200;LOC_Os01g69210) 3.2.1.106 pubmed
Oryza sativa Japonica Group EEE55907.1
BAB86175.1
BAF07139.1
BAS75938.1
A0A0P0VC79
B9EVX4
Q0JGI9
Q8RZJ2
 
 α-glucosidase (processing) 3.2.1.106 pubmed
Rattus rattus AAC36477.1
NP_113937.1
O88941  
 processing α-1,2-glucosidase I (Cwh41;Cwht1;Gls1;ScCwh41p;YGL027c;Der7) 3.2.1.106 pubmed
Saccharomyces cerevisiae S288c AAC49157.1
CAA96728.1
NP_011488.1
P53008 4J5T[A]
 mannosylglycerate hydrolase (MgH;SELMODRAFT_437793) 3.2.1.170 pubmed
Selaginella moellendorffii EFJ37158.1 D8QTR2  
 α-glucosidase (Cwh41;SsCWH41;SPSK05967;HMPREF1624_08365) 3.2.1.106 pubmed
Sporothrix schenckii ATCC 58251 ERS95155.1 U7PKV5  
  mannosyl-oligosaccharide α-glucosidase (CTHT_0061620) 3.2.1.106 pubmed
Thermochaetoides thermophila DSM 1495 EGS18147.1 G0SFD1 7R6J[A,B]
7REV[A,B]
7T66[A,B]
7T68[A,B]
7T6W[A,B]
7T8V[A,B]
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