Glycoside Hydrolase Family 63

Known Activities	processing α-glucosidase (EC 3.2.1.106); α-1,3-glucosidase (EC 3.2.1.84); α-glucosidase (EC 3.2.1.20)
Mechanism	Inverting
Clan	GH-G
3D Structure Status	( α / α ) ₆
Catalytic Nucleophile/Base	Not known
Catalytic Proton Donor	Not known
External resources	InterPro; PFAM;
Statistics	GenBank accession (359); Uniprot accession (167); PDB accession (6); 3D entries (3); cryst (1)

Summary

All (279) Archaea (1) Bacteria (197) Eukaryota (81) Structure (3 - 1 cryst) Characterized (11)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-glucosidase (YgjK;b3080)	3.2.1.20 3.2.1.84	Escherichia coli K-12 MG1655	AAA57881.1 AAC76115.1 NP_417551.1	P42592	2DS3[A,B] 3C67[A,B] 3C68[A,B] 3C69[A,B] 3D3I[A,B]
ECDH10B_3255	3.2.1.20 3.2.1.84	Escherichia coli str. K-12 substr. DH10B	ACB04164.1	B1XG84
YgjK	3.2.1.20 3.2.1.84	Escherichia coli str. K-12 substr. W3110	BAE77130.1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-1,2-glucosidase / α-glucosidase I (Gcs1;KNF;KNOPF;At1g67490 )	3.2.1.106	Arabidopsis thaliana	AAC18786.1 AAG52297.1 AAL17718.1 AEE34653.1 AEE34654.1 BAC43508.1 CAC34725.1 NP_176916.1 NP_176916.2	O64796 Q8GWC8 Q940D4 Q9C5B4 Q9CAG7
processing α-glucosidase I	3.2.1.106	Aspergillus brasiliensis ATCC 9642	BAK64066.1
α-glucosidase I (Cwh41;AfCwh41)	3.2.1.106	Aspergillus fumigatus YJ-407	AAR23808.1	Q6S9W4
α-glucosidase I (Cwh41)	3.2.1.106	Candida albicans SC5314	ABB97046.1
α-glucosidase (processing) (Gcs1)	3.2.1.106	Homo sapiens	AAH28337.1 AAI17251.1 AAI17253.1 BAF85242.1 BAF85408.1 CAA60683.1 CAD19636.1 NP_006293.1	A8K938 Q13724 Q13724.5
α-glucosidase I (Gcs1)	3.2.1.106	Mus musculus	AAD00906.1 AAH51949.1 BAE26149.1 BAE30817.1 BAE30968.1 BAE34029.1 NP_065644.1	Q80UM7 Q80UM7.1
α-glucosidase (processing)	3.2.1.106	Rattus rattus	AAC36477.1 NP_113937.1	O88941.1
α-glucosidase I (Cwh41;Gls1;YGL027c;Der7)	3.2.1.106	Saccharomyces cerevisiae S288c	AAC49157.1 CAA96728.1 NP_011488.1	P53008	cryst

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.