Activities in Sub Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (226); Uniprot accession (1);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
HGI09_09470		Streptomyces collinus L2	UJA13648.1			40
HGI10_54630		Streptomyces collinus SQ	UJA11486.1			40
B446_30100 (probable fragment)		Streptomyces collinus Tu 365	AGS72824.1			40
S1361_32550 (fragment)		Streptomyces cyanogenus S136	QTE02108.1			40
S1361_32545 (fragment)		Streptomyces cyanogenus S136	QTE02107.1			40
N8I84_32600		Streptomyces cynarae HUAS 13-4	UXY22918.1			40
D9753_05755		Streptomyces dangxiongensis Z022	AYN38507.1			40
M4V62_37310		Streptomyces durmitorensis MS405	UQT60272.1			40
D3X13_05440		Streptomyces fradiae NKZ-259	AYA20982.1			40
H4W23_33570		Streptomyces gardneri ATCC 15439	QPK49084.1			40
SGFS_029450		Streptomyces graminofaciens A-8890	BBC31651.1			40
SGFS_100530 (fragment)		Streptomyces graminofaciens A-8890	BBC38759.1			40
DWG14_08412 (Cela_1)		Streptomyces griseorubiginosus 3E-1	AYC44104.1			40
ELQ87_06455		Streptomyces griseoviridis F1-27	AZS83978.1			40
DDJ31_32900		Streptomyces griseoviridis K61	QCN89169.1			40
J2N69_31470		Streptomyces huasconensis D23	UFQ19135.1			40
DWB77_07127 (CelA)		Streptomyces hundungensis BH38	AYG84912.1			40
SHJG_7499 (partial)		Streptomyces hygroscopicus subsp. jinggangensis 5008	AEY92766.1			40
SHJGH_7259		Streptomyces hygroscopicus subsp. jinggangensis TL01	AGF66921.1			40
SHL15_6376		Streptomyces hygroscopicus subsp. limoneus KCTC 1717	ALO97412.1			40
SHXM_04453		Streptomyces hygroscopicus XM201	AQW50990.1			40
SIRAN6226		Streptomyces iranensis	CDR09620.1			40
SLA_0107		Streptomyces laurentii ATCC 31255	BAU81062.1			40
J3S85_33870		Streptomyces lavenduligriseus Tu901	WDM16038.1			40
Sle_18090		Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963)	CQR61271.1			40
SMALA_2845		Streptomyces malaysiensis DSM 4137	ATL83079.1 QDL72732.1			40
SMIR_03290		Streptomyces mirabilis P16B-1	QUW78287.1			40
POD33_25995		Streptomyces moderatus DT446	WCH95404.1			40
CP978_27420		Streptomyces nodosus ATCC 14899	QEV41787.1			40
SNOD_27135		Streptomyces nodosus ATCC 14899	AJE43292.1			40
DVK44_00900		Streptomyces paludis GSSD-12	AXG76470.1			40
LIV37_31490		Streptomyces rapamycinicus NRRL 5491	UTP33454.1			40
M271_31005		Streptomyces rapamycinicus NRRL 5491	AGP57633.1			40
LJB45_26360		Streptomyces rapamycinicus SRMK07	UTO65496.1			40
CP984_26115		Streptomyces rimosus ATCC 10970	QEV77995.1			40
V519_030420		Streptomyces rimosus R6-500	QGY69610.1			40
SRIM_014725		Streptomyces rimosus subsp. rimosus ATCC 10970	QST81248.1			40
SRIMDV3_23470		Streptomyces rimosus subsp. rimosus DV3	UTJ15202.1			40
SRIMHP_23580		Streptomyces rimosus subsp. rimosus HP126	UTH97106.1			40
SRIMR7_26210		Streptomyces rimosus subsp. rimosus R7	UNZ05651.1			40
FMM49_26670		Streptomyces rimosus subsp. rimosus SRI-4018v0	QTL88842.1			40
CTZ40_26150		Streptomyces rimosus WT5260	QDA06720.1			40
HUT11_31960		Streptomyces seoulensis A01	QKW30226.1			40
A7J05_06405		Streptomyces silaceus ACCC40021	APY90660.1			40
I1A49_18140		Streptomyces solisilvae HNM0141	QPI56589.1			40
SAMN05444521_1740		Streptomyces sp. 3214.6	SHH75332.1			40
IOD14_13275		Streptomyces sp. A2-16	QUC57692.1			40
N7U49_38130		Streptomyces sp. AD2-2	UXX97833.1			40
AS97_33555		Streptomyces sp. AgN23	AJZ85737.1			40
PZB77_28310		Streptomyces sp. AM 2-1-1	WEH43094.1			40
C2142_36630		Streptomyces sp. CB01881	AUY53494.1			40
AS200_10470		Streptomyces sp. CdTB01	ALV32415.1			40
Q2K21_13185		Streptomyces sp. CGMCC 4.7035	WNB98952.1			40
HB370_40810		Streptomyces sp. DSM 40868	QIS75498.1			40
WJM95_27335		Streptomyces sp. f51	WYH85886.1			40
A6P39_010165		Streptomyces sp. FXJ1.172	WEO94338.1			40
KQY30_33060		Streptomyces sp. GMY02	QXE38350.1			40
KBP30_08245		Streptomyces sp. Go40/10 Go 40/10	UFR01166.1			40
LUX31_06655		Streptomyces sp. GQFP	UIX29742.1			40
LUV23_18290		Streptomyces sp. HNM0561	UHH18090.1			40
N8I87_33670		Streptomyces sp. HUAS 15-9	UXY31019.1			40
O1G22_07930		Streptomyces sp. HUAS 2-6	WBO62750.1			40
PGH47_35175		Streptomyces sp. HUAS 31	WCE00640.1			40
RLT57_26880		Streptomyces sp. ITFR-21	WNI18794.1			40
PPN52_31435		Streptomyces sp. JCM 35825	WCL88755.1			40
NOO62_33165		Streptomyces sp. Je 1-369	WAL98905.1			40
R9806_05780		Streptomyces sp. KN37	WPO70170.1			40
RKE30_26035		Streptomyces sp. Li-HN-5-11	WNM33603.1			40
RKE30_27125		Streptomyces sp. Li-HN-5-11	WNM33780.1			40
RKE32_24540		Streptomyces sp. Li-HN-5-13	WNW40458.1			40
CFP59_05776 (EgL)		Streptomyces sp. M56	AUA13610.1			40
KGS77_22990		Streptomyces sp. MST-110588	UNO41881.1			40
R2B38_35045		Streptomyces sp. N50	WOX13731.1			40
QFW82_28980		Streptomyces sp. NA07423	WHX20785.1			40
OG906_00825		Streptomyces sp. NBC_01426	WUX80042.1			40
OG627_31990		Streptomyces sp. NBC_01429	WUX71115.1			40
OG522_35865		Streptomyces sp. NBC_01431	WUX64028.1			40
C6376_33440		Streptomyces sp. P3	AVV45538.1			40
V2W30_32945		Streptomyces sp. Q6	WWQ67672.1			40
GPZ77_31470		Streptomyces sp. QHH-9511	QGZ52263.1			40
HYQ63_16245		Streptomyces sp. Rer75	QLH21966.1			40
HEP84_41205		Streptomyces sp. RLB1-33	QIY74572.1			40
FNV59_42665		Streptomyces sp. RLB1-8	QDO63926.1			40
FNV58_43680		Streptomyces sp. RLB1-9	QDO01948.1			40
FNV62_41785		Streptomyces sp. RLB3-17	QDO43763.1			40
FNV60_40415		Streptomyces sp. RLB3-5	QDO53681.1			40
FNV61_43420		Streptomyces sp. RLB3-6	QDN91455.1			40
FNV63_42290		Streptomyces sp. S1A1-3	QDO33806.1			40
FNV64_43800		Streptomyces sp. S1A1-7	QDN81557.1			40
FNV65_42265		Streptomyces sp. S1A1-8	QDO23680.1			40
HEP87_42750		Streptomyces sp. S1D4-11	QIY99415.1			40
FNV66_41935		Streptomyces sp. S1D4-14	QDN71226.1			40
FNV67_43085		Streptomyces sp. S1D4-20	QDN61172.1			40
FNV68_44505		Streptomyces sp. S1D4-23	QDO12280.1			40
N6H00_15050		Streptomyces sp. S465	WAP56178.1			40
PS467_16040		Streptomyces sp. SCA4-21	WNE96732.1			40
RVR_3329		Streptomyces sp. SN-593	BBA97536.1			40
U5640_06040		Streptomyces sp. SS7	WYV85261.1			40
DMA15_31905		Streptomyces sp. WAC 01529	AZM56619.1			40
C5L38_04485		Streptomyces sp. WAC00288	AVH94409.1			40
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