Glycoside Hydrolase Family 5 / Subf 40

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (44); Uniprot accession (6);
All (41) Bacteria (40) Eukaryota (1)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 L083_3363 (CelA)   Actinoplanes sp. N902-109 AGL16873.1     40
 ACWT_6205   Actinoplanes sp. SE50 ATO85620.1     40
 ACPL_6337 (CelA)   Actinoplanes sp. SE50/110 AEV87219.1
SLM03033.1
    40
 B737_8016   Amycolatopsis mediterranei RB AGT88677.1     40
 RAM_41810   Amycolatopsis mediterranei S699 AEK46829.1
AFO81548.1
    40
 AMED_8139   Amycolatopsis mediterranei U32 ADJ49840.1 D8HLV8   40
 SD37_26450   Amycolatopsis orientalis B-37 ANN22051.1     40
 Caci_3718   Catenulispora acidiphila DSM 44928 ACU72620.1 C7QC01   40
 Caci_6685   Catenulispora acidiphila DSM 44928 ACU75531.1 C7Q038   40
 GA0004736_3138   Curtobacterium sp. 9128 SBN64180.1     40
 KSE_56690   Kitasatospora setae KM-6054 BAJ31442.1 E4N0B4   40
 SAMN04488570_0245   Marmoricola scoriae DSM 22127 SDR74715.1     40
 GA0070618_5384   Micromonospora echinospora DSM 43816 SCF33320.1     40
 GA0070623_1484   Micromonospora rifamycinica DSM 44983 SCG47572.1     40
 I601_0711 (EgL)   Nocardioides dokdonensis FR1436 ANH37161.1     40
 Noca_0723   Nocardioides sp. JS614 ABL80248.1 A1SEL3   40
 BV401_17870   Streptomyces autolyticus CGMCC0516 AQA12038.1     40
 SAV1854 (CelA2)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69565.1
NP_823030.1
    40
 SBI_06900 (Cela1)   Streptomyces bingchenggensis BCW-1 ADI10020.1 D7C1F5   40
 SCAT_p0083   Streptomyces cattleya NRRL 8057 = DSM 46488 CCB71109.1     40
 SCATT_p16620   Streptomyces cattleya NRRL 8057 = DSM 46488 AEW99855.1     40
 B446_30100 (probable fragment)   Streptomyces collinus Tu 365 AGS72824.1     40
 SHJG_7499 (partial)   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92766.1     40
 SHJGH_7259   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF66921.1     40
 SHL15_6376   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO97412.1     40
 SHXM_04453   Streptomyces hygroscopicus XM201 AQW50990.1     40
 SIRAN6226   Streptomyces iranensis CDR09620.1     40
 SLA_0107   Streptomyces laurentii ATCC 31255 BAU81062.1     40
 Sle_18090   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR61271.1     40
 SMALA_2845   Streptomyces malaysiensis DSM 4137 ATL83079.1     40
 SNOD_27135   Streptomyces nodosus ATCC 14899 AJE43292.1     40
 M271_31005   Streptomyces rapamycinicus NRRL 5491 AGP57633.1     40
 A7J05_06405   Streptomyces silaceus ACCC40021 APY90660.1     40
 SAMN05444521_1740   Streptomyces sp. 3124.6 SHH75332.1     40
 AS200_10470   Streptomyces sp. CdTB01 ALV32415.1     40
 SVEN_6597 (fragment)   Streptomyces venezuelae ATCC 10712 CCA59883.1     40
 BN2537_3229   Streptomyces venezuelae ATCC 15439 CUM37132.1     40
 AQF52_6684   Streptomyces venezuelae ATCC 15439 ALO12277.1     40
 SVTN_32840   Streptomyces vietnamensis GIM4.0001 AJF70118.1     40
 Strvi_8131   Streptomyces violaceusniger Tu 4113 AEM87454.1     40
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