Glycoside Hydrolase Family 5 / Subf 18

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (154); Uniprot accession (21);
All (150) Bacteria (150)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 PACID_31160   Acidipropionibacterium acidipropionici ATCC 4875 AFV90876.1     18
 AXH35_08595   Acidipropionibacterium acidipropionici ATCC 55737 AMS07131.1     18
 ASQ49_06605   Acidipropionibacterium acidipropionici CGMCC 1.2230 ALN16772.1     18
 A8L58_10040   Acidipropionibacterium acidipropionici F3E8 AOZ48331.1     18
 BWX38_08325   Acidipropionibacterium acidipropionici WSH1105 APZ09244.1     18
 SAMN04489714_2031   Actinomyces radingae DSM 9169 SDU07880.1     18
 L083_0808   Actinoplanes sp. N902-109 AGL14318.1     18
 Amir_4607   Actinosynnema mirum DSM 43827 ACU38440.1 C6WLP7   18
 CNX65_22910   Actinosynnema pretiosum X47 ATE55778.1     18
 B737_2653   Amycolatopsis mediterranei RB AGT83317.1     18
 RAM_13630   Amycolatopsis mediterranei S699 AEK41214.1
AFO76188.1
    18
 AMED_2681   Amycolatopsis mediterranei U32 ADJ44476.1 D8HY34   18
 Arch_0033   Arcanobacterium haemolyticum DSM 20595 ADH91800.1 D7BLK1   18
 SAMN04489737_0425   Arcanobacterium phocae DSM 10002 SDU78319.1     18
 AOC05_14730   Arthrobacter alpinus R3.8 ALE93292.1     18
 CGQ24_15805   Arthrobacter sp. 7749 ASN40324.1     18
 MB46_17100   Arthrobacter sp. A3 ALV46941.1     18
 UM93_09880   Arthrobacter sp. IHBB 11108 AJT41747.1     18
 ART_2884   Arthrobacter sp. PAMC 25486 AIY02483.1     18
 CGK93_22015   Arthrobacter sp. YN ASN22040.1     18
 CGK93_22205   Arthrobacter sp. YN ASN22069.1     18
 BAST_0565   Bifidobacterium asteroides PRL2011 AFU71154.1     18
 B12L_1041   Bifidobacterium breve 12L AHJ15788.1     18
 B689b_1168   Bifidobacterium breve 689b AHJ23177.1     18
 HMPREF9228_0729   Bifidobacterium breve ACS-071-V-Sch8b AEF27614.1     18
 RY69_694   Bifidobacterium breve BR3 ALE12953.1     18
 BBBR_1099   Bifidobacterium breve DSM 20213 = JCM 1192 BAR00138.1     18
 B7017_1116   Bifidobacterium breve JCM 7017 AHJ17612.1     18
 B7019_1213   Bifidobacterium breve JCM 7019 AHJ19485.1     18
 BBL520_06555   Bifidobacterium breve LMC520 AQM43237.1     18
 B2258_1115   Bifidobacterium breve NCFB 2258 AHJ21311.1     18
 BS27_1164   Bifidobacterium breve S27 AHJ24964.1     18
 Bbr_1144   Bifidobacterium breve UCC2003 ABE95822.1     18
 BL105A_1220   Bifidobacterium longum 105-A BAP83849.1     18
 BBG7_1331   Bifidobacterium longum BG7 ALE36519.1     18
 GS08_06665   Bifidobacterium longum BXY01 AIF90798.1     18
 BLD_0195   Bifidobacterium longum DJO10A ACD97641.1 B3DQP5   18
 BL1333   Bifidobacterium longum NCC2705 AAN25133.1
NP_696497.1
Q8G4P5   18
 SAMN04489749_0829   Bifidobacterium longum Su859 SDO44614.1     18
 BLIF_1312   Bifidobacterium longum subsp. infantis 157F BAJ71452.1     18
 Blon_2377   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53432.1 B7GNS6   18
 BLIJ_2448   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 BAJ70025.1     18
 RY67_1643   Bifidobacterium longum subsp. infantis BT1 ALE09655.1     18
 RY67_518   Bifidobacterium longum subsp. infantis BT1 ALE08581.1     18
 BBMN68_220   Bifidobacterium longum subsp. longum BBMN68 ADQ02913.1 E4R1Y2   18
 BBL306_1348   Bifidobacterium longum subsp. longum CCUG30698 ALO74877.1     18
 BIL_06980   Bifidobacterium longum subsp. longum F8 CBK70291.1 D6DCS0   18
 BLGT_06810   Bifidobacterium longum subsp. longum GT15 AIW44813.1     18
 BLJ_1281   Bifidobacterium longum subsp. longum JDM301 ADH00732.1 D6ZV26   18
 B8809_1134   Bifidobacterium longum subsp. longum NCIMB8809 ALO72805.1     18
 BBSC_1812   Bifidobacterium scardovii JCM 12489 = DSM 13734 BAQ31892.1     18
 Bfae_10930   Brachybacterium faecium DSM 4810 ACU84941.1 C7MBG8   18
 BH708_13780   Brachybacterium sp. P6-10-X1 APX33606.1     18
 BH708_03855   Brachybacterium sp. P6-10-X1 APX32004.1     18
 CFK39_00935   Brachybacterium sp. VR2415 ASK64645.1     18
 Caci_2257   Catenulispora acidiphila DSM 44928 ACU71175.1 C7QJF2   18
 GA0004736_1675   Curtobacterium sp. 9128 SBN62767.1     18
 BJK06_02620   Curtobacterium sp. BH-2-1-1 AOX64816.1     18
 NI26_04865   Curtobacterium sp. MR_MD2014 AIV39720.1     18
 VO62_07035   Cutibacterium acnes A1-14 ALU23723.1     18
 RN83_07775   Cutibacterium acnes KCOM 1861 (= ChDC B594) ALD69971.1     18
 ALW29_07335   Cutibacterium acnes PA_12_1_L1 ALT42425.1     18
 ALW27_07315   Cutibacterium acnes PA_12_1_R1 ALT40185.1     18
 ALW33_07370   Cutibacterium acnes PA_15_1_R1 ALT44693.1     18
 ALW23_07465   Cutibacterium acnes PA_15_2_L1 ALT37912.1     18
 ALW21_07410   Cutibacterium acnes PA_21_1_L1 ALT35598.1     18
 ALW22_07375   Cutibacterium acnes PA_30_2_L1 ALT33333.1     18
 PALO_03800   Cutibacterium avidum 44067 AGJ77370.1     18
 BFS79_11990   Cutibacterium avidum DPC 6544 AOG29094.1     18
 DAD186_02050   Dermabacter vaginalis AD1-86 ANP26764.1     18
 Kfla_5464   Kribbella flavida DSM 17836 ADB34475.1 D2PMA7   18
 KALB_7803   Kutzneria albida DSM 43870 AHI01161.1     18
 BBK82_04670   Lentzea guizhouensis DHS C013 ANZ35479.1     18
 VV02_12290   Luteipulveratus mongoliensis MN07-A0370 AKU16465.1     18
 B2G67_16940   Microbacterium foliorum 122 AQY02959.1     18
 BO218_13700   Microbacterium paludicola CC3 APF35869.1     18
 SAMN04489809_1783   Microbacterium paraoxydans DSM 15019 SDS40580.1     18
 BMW26_16160   Microbacterium sp. 1.5R APH46312.1     18
 AKG07_11415   Microbacterium sp. CGR1 AKV86804.1     18
 AXH82_05045   Microbacterium sp. PAMC 28756 AMG82826.1     18
 AB663_000615   Microbacterium sp. XT11 ALX65853.1     18
 BWO91_14120 (fragment)   Plantibacter flavus 251 AQX82249.1     18
 PAZ_c15370   Propionibacterium acnes 266 AEE72695.1     18
 TIB1ST10_07515   Propionibacterium acnes 6609 AEH29790.1     18
 PAC1_07655   Propionibacterium acnes C1 AFU41284.1     18
 TIA1EST1_07285   Propionibacterium acnes hdn-1 AID36141.1     18
 PAGK_0722   Propionibacterium acnes HL096PA1 AGJ79569.1     18
 PPA1460   Propionibacterium acnes KPA171202 AAT83208.1 Q6A7Q7   18
 HMPREF0675_4517   Propionibacterium acnes SK137 ADD99013.1 D4HEZ6   18
 TIIST44_00285   Propionibacterium acnes subsp. defendens ATCC 11828 AER04593.1     18
 TIA2EST22_07285   Propionibacterium acnes TypeIA2 P.acn17 AEW81769.1     18
 TIA2EST36_07270   Propionibacterium acnes TypeIA2 P.acn31 AEW84036.1     18
 TIA2EST2_07195   Propionibacterium acnes TypeIA2 P.acn33 AEW79524.1     18
 BCB70_11200   Propionibacterium sp. oral taxon 193 F0672 AOH46374.1     18
 AFB00_25645   Pseudonocardia sp. HH130630-07 ANY09081.1     18
 SACE_5271 (fragment)   Saccharopolyspora erythraea NRRL 2338 CAM04510.1     18
 Sare_1078   Salinispora arenicola CNS-205 ABV96986.1 A8M5B2   18
 Strop_1185   Salinispora tropica CNB-440 ABP53655.1 A4X455   18
 Sked_14820   Sanguibacter keddieii DSM 10542 ACZ21418.1 D1BFQ7   18
 Snas_2011   Stackebrandtia nassauensis DSM 44728 ADD41706.1 D3Q0H0   18
 SMD11_0766   Streptomyces albireticuli SMD11 ARZ66432.1     18
 SMD44_07664   Streptomyces alboflavus MDJK44 ARX88177.1     18
 DC74_7129   Streptomyces albulus NK660 AIA07557.1     18
 SAZ_36960   Streptomyces albulus ZPM AKA07371.1     18
 SLNHY_1504   Streptomyces albus BK3-25 AOU76195.1     18
 SLNWT_1503   Streptomyces albus DSM 41398 AJE81879.1     18
 SAM40697_6661   Streptomyces ambofaciens DSM 40697 ANB10614.1     18
 SAV7274   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC74985.1
NP_828450.1
    18
 SBI_00829   Streptomyces bingchenggensis BCW-1 ADI03950.1 D7C4C8   18
 SCAT_p1024   Streptomyces cattleya NRRL 8057 = DSM 46488 CCB72048.1     18
 SCATT_p07120   Streptomyces cattleya NRRL 8057 = DSM 46488 AEW98905.1     18
 SCO0949 or SCM11.04c   Streptomyces coelicolor A3(2) CAB61915.1
NP_625246.1
Q9RIV7   18
 B446_31815   Streptomyces collinus Tu 365 AGS73167.1     18
 BN159_1456   Streptomyces davawensis JCM 4913 CCK25835.1     18
 B1H19_36315   Streptomyces gilvosporeus F607 ARF58923.1     18
 AVL59_16115   Streptomyces griseochromogenes ATCC 14511 ANP56544.1     18
 SHJG_0530   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY85807.1     18
 SHJGH_0363   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF60029.1     18
 SHL15_8397   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO99347.1     18
 ABB07_03975   Streptomyces incarnatus NRRL 8089 AKJ09211.1     18
 SLINC_6472   Streptomyces lincolnensis NRRL 2936 ANS68696.1     18
 SLIV_33190   Streptomyces lividans TK24 AIJ17522.1     18
 SL103_21365   Streptomyces lydicus 103 AOP48446.1     18
 SNOD_04995   Streptomyces nodosus ATCC 14899 AJE39452.1     18
 SNOUR_06490   Streptomyces noursei ATCC 11455 ANZ14617.1     18
 B1H29_04150   Streptomyces pactum ACT12 AQS66237.1     18
 Spa2297_28905   Streptomyces parvulus 2297 ANJ10645.1     18
 LK06_001720   Streptomyces pluripotens MUSC 135 ARP73894.1     18
 LK07_02800   Streptomyces pluripotens MUSC 137 ASN28157.1     18
 SPRI_6676   Streptomyces pristinaespiralis HCCB 10218 ALC24982.1     18
 BFF78_05005   Streptomyces puniciscabiei TW1S1 AOR36892.1     18
 TUE45_00150   Streptomyces reticuli CUW25440.1     18
 A7J05_04260   Streptomyces silaceus ACCC40021 APY85054.1     18
 SAMN05428941_1007   Streptomyces sp. 2114.2 SDS71412.1     18
 GZL_01518   Streptomyces sp. 769 AJC54118.1     18
 T261_0639   Streptomyces sp. A02 AJT62328.1     18
 NI25_03335   Streptomyces sp. CCM_MD2014 AIV32684.1     18
 AS200_07935   Streptomyces sp. CdTB01 ALV31970.1     18
 B1K54_26600   Streptomyces sp. fd1-xmd AQT74744.1     18
 M444_25515   Streptomyces sp. Mg1 AKL68224.1     18
 STRMOE7_34330   Streptomyces sp. MOE7 ARH94536.1     18
 QR97_37890   Streptomyces sp. PBH53 AKN74717.1     18
 A8713_28445   Streptomyces sp. SAT1 ANH94624.1     18
 B6R96_09720   Streptomyces sp. Sge12 ARE74178.1     18
 SAMN05216371_6717   Streptomyces sp. TLI_053 SDT81587.1     18
 BSL84_24760   Streptomyces sp. TN58 APU42518.1     18
 BN2537_14531   Streptomyces venezuelae ATCC 15439 CUM42783.1     18
 AQF52_1325   Streptomyces venezuelae ATCC 15439 ALO06921.1     18
 Sros_5000   Streptosporangium roseum DSM 43021 ACZ87799.1 D2B8I9   18
 BW730_02835   Tessaracoccus sp. NSG39 AQP46627.1     18
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