Glycoside Hydrolase Family 45

Activities in FamilyGlucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Mechanism Inverting e
3D Structure Status6-stranded β-barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental).
Noteformerly known as cellulase family K; distantly related to plant expansins
External resourcesCAZypedia; Expansin; PROSITE;
Statistics GenBank accession (680); Uniprot accession (102); PDB accession (34); 3D entries (10); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 endo-β-1,4-glucanase (EG27II) 3.2.1.4 Ampullaria crossean ABR92638.1 A7KMF0
5XBU[A] 1.00
5XBX[A] β-D-Glcp-(1-4)-β-D-Glcp
1.04
5XC4[A] β-D-Glcp-(1-4)-β-D-Glcp
1.42
5XC8[A] β-D-Glcp-(1-4)-β-D-Glcp
1.45
5XC9[A] β-D-Glcp-(1-4)-β-D-Glcp
1.28
5XCA[A] β-D-Glcp-(1-4)-β-D-Glcp
1.35
2
 endo-β-1,4-glucanase (Cel;CaCel) 3.2.1.4 Cryptopygus antarcticus ACV50414.1
ACV50415.1
D3GDK4
5H4U[A,B,C] 2.60
1
 endo-β-1,4-glucanase (GtGH45; GLOTRDRAFT_59933) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 EPQ56593.1 S7QB86
8BZQ[A] 1.30
3
 endo-β-1,4-glucanase (Egl3) 3.2.1.4 Humicola grisea var. thermoidea BAA74956.1
AAE55435.1
AAN19009.1
O93782
P43316
1HD5[A] 1.7
1
 endo-β-1,4-glucanase V (EGV; EG V; NCE5) (Cel45A) 3.2.1.4 Humicola insolens DSM 1800 CAB42307.1
AAE16508.1
AAN23440.1
AAO30277.1
AAO30279.1
AAX00991.1
AAY74558.1
ABA35703.1
ABN29330.1
CAA01574.1
CAA01681.1
CAA01683.1
CAA01696.1
CAA01698.1
CAJ21530.1
P43316
2ENG[A] 1.50
3ENG[A] β-D-Glcp-(1-4)-β-D-Glcp
1.90
4ENG[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
1
 endo-β-1,4-glucanase (MaCel45A) (Cel45A) 3.2.1.4 Melanocarpus albomyces CAD56665.1
AAU96162.1
QCO31627.1
Q8J0K8
1L8F[A] 1.80
1OA7[A] β-D-Glcp-(1-4)-β-D-Glcp
2.0
1OA9[A] 2.0
1
 endoglucanase (Eg) 3.2.1.4 Mytilus edulis CAC59695.1
CAC59694.1
P82186
Q95P02
1WC2[A] 1.2
2
 endoglucanase (NcCel45A;NCU05121.1) (Cel45A) 3.2.1.4 Neurospora crassa OR74A CAD70529.1
EAA27871.1
XP_324478.1
Q1K5M0
Q872Q1
6MVI[A] 1.89
6MVJ[A] β-D-Glcp-(1-4)-β-D-Glcp
1.81
1
 endoglucanase V (EGV;PcCel45A) (Cel45A) 3.2.1.4 Phanerochaete chrysosporium K-3 BAG68300.1
AEK06231.1
B3Y002
G0ZPJ6
3X2G[A] 1.00
3X2H[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
0.99
3X2I[A] 1.60
3X2J[A] 1.30
3X2K[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.18
3X2L[A] 0.83
3X2M[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
0.64
3X2N[A] 1.20
3X2O[A] 1.50
3X2P[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.52
4ZM7[A] 0.70
5KJO[A] 1.47
5KJQ[A] β-D-Glcp-(1-4)-β-D-Glcp
1.70
3
 endo-β-1,4-glucanase (THITE_2110957) 3.2.1.4 Thermothielavioides terrestris NRRL 8126 AEO64667.1 G2QVH7
5GLX[A] 1.42
5GLY[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.58
5GM9[A] β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
1.36
1
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